| 1. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
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| 4. |
- Ramilowski, JA, et al.
(författare)
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Functional annotation of human long noncoding RNAs via molecular phenotyping
- 2020
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Ingår i: Genome research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 30:7, s. 1060-1072
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Tidskriftsartikel (refereegranskat)abstract
- Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.
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| 5. |
- Harrison, Sarah M., et al.
(författare)
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BPS Algebras in 2D String Theory
- 2022
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Ingår i: Annales Henri Poincare. - : Springer Science and Business Media LLC. - 1424-0637 .- 1424-0661. ; 23, s. 3667-3752
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Tidskriftsartikel (refereegranskat)abstract
- We discuss a set of heterotic and type II string theory compactifications to 1 + 1 dimensions that are characterized by factorized internal worldsheet CFTs of the form V1⊗ V¯ 2, where V1, V2 are self-dual (super) vertex operator algebras. In the cases with spacetime supersymmetry, we show that the BPS states form a module for a Borcherds–Kac–Moody (BKM) (super)algebra, and we prove that for each model the BKM (super)algebra is a symmetry of genus zero BPS string amplitudes. We compute the supersymmetric indices of these models using both Hamiltonian and path integral formalisms. The path integrals are manifestly automorphic forms closely related to the Borcherds–Weyl–Kac denominator. Along the way, we comment on various subtleties inherent to these low-dimensional string compactifications.
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| 6. |
- Harrison, Sarah M., et al.
(författare)
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Fun with F 24
- 2021
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2021:2
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Tidskriftsartikel (refereegranskat)abstract
- We study some special features of F24, the holomorphic c = 12 superconformal field theory (SCFT) given by 24 chiral free fermions. We construct eight different Lie superalgebras of “physical” states of a chiral superstring compactified on F24, and we prove that they all have the structure of Borcherds-Kac-Moody superalgebras. This produces a family of new examples of such superalgebras. The models depend on the choice of an N = 1 supercurrent on F24, with the admissible choices labeled by the semisimple Lie algebras of dimension 24. We also discuss how F24, with any such choice of supercurrent, can be obtained via orbifolding from another distinguished c = 12 holomorphic SCFT, the N = 1 supersymmetric version of the chiral CFT based on the E8 lattice.
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| 7. |
- Harrison, S. M., et al.
(författare)
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Fun with F24
- 2021
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2021:2
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Tidskriftsartikel (refereegranskat)abstract
- We study some special features of F24, the holomorphic c = 12 superconformal field theory (SCFT) given by 24 chiral free fermions. We construct eight different Lie superalgebras of “physical” states of a chiral superstring compactified on F24, and we prove that they all have the structure of Borcherds-Kac-Moody superalgebras. This produces a family of new examples of such superalgebras. The models depend on the choice of an N = 1 supercurrent on F24, with the admissible choices labeled by the semisimple Lie algebras of dimension 24. We also discuss how F24, with any such choice of supercurrent, can be obtained via orbifolding from another distinguished c = 12 holomorphic SCFT, the N = 1 supersymmetric version of the chiral CFT based on the E8 lattice. © 2021, The Author(s).
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| 8. |
- Paquette, J A, et al.
(författare)
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D/H in the refractory organics of comet 67P/Churyumov-Gerasimenko measured by Rosetta/COSIMA
- 2021
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Ingår i: monthly notices of the royal astronomical society. ; 504:4
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Tidskriftsartikel (refereegranskat)abstract
- The D/H ratio is a clue to the origin and evolution of hydrogen-bearing chemical species in Solar system materials. D/H has been observed in the coma of many comets, but most such measurements have been for gaseous water. We present the first in situ measurements of the D/H ratios in the organic refractory component of cometary dust particles collected at very low impact speeds in the coma of comet 67P/Churyumov-Gerasimenko (hereafter 67P) by the COSIMA instrument onboard Rosetta. The values measured by COSIMA are spatial averages over an approximately 35 × 50 µm2 area. The average D/H ratio for the 25 measured particles is (1.57 ± 0.54) × 10−3, about an order of magnitude higher than the Vienna Standard Mean Ocean Water (VSMOW), but more than an order of magnitude lower than the values measured in gas-phase organics in solar-like protostellar regions and hot cores. This relatively high averaged value suggests that refractory carbonaceous matter in comet 67P is less processed than the most primitive insoluble organic matter (IOM) in meteorites, which has a D/H ratio in the range of about 1 to 7 × 10−4. The cometary particles measured in situ also have a higher H/C ratio than the IOM. We deduce that the measured D/H in cometary refractory organics is an inheritance from the presolar molecular cloud from which the Solar system formed. The high D/H ratios observed in the cometary particles challenges models in which high D/H ratios result solely from processes that operated in the protosolar disc.
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