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Träfflista för sökning "WFRF:(Pastor Oscar) srt2:(2014)"

Sökning: WFRF:(Pastor Oscar) > (2014)

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  • Escott-Price, Valentina, et al. (författare)
  • Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
  • 2014
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6, s. e94661-
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
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  • Zdravkovic, Jelena, et al. (författare)
  • On the Capability Notion in Business Informatics : [Opening]
  • 2014
  • Ingår i: [Proceedings of] The 1st International Workshop on Capability-oriented Business Informatics (CoBI 2014). ; , s. 1-2
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The business environments of today are changing rapidly, entailing complex anddynamic organizational constellations. Enterprises operating in these conditions needto have the capability to deliver their services in a variety of business contexts withsustainable quality and moreover to leverage them to competitive advantage. Latelythe notion of capability has gained a growing attention, due to a number of factors:the notion directs business investment focus, it can be used as a baseline for businessplanning, and it leads directly to service specification and design.
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  • Resultat 1-3 av 3
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2014 (3)Ta bort avgränsningen

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