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Sökning: WFRF:(Pastor Oscar) > (2015)

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  • Berzisa, Solvita, et al. (författare)
  • Capability Driven Development : An Approach to Designing Digital Enterprises
  • 2015
  • Ingår i: Business & Information Systems Engineering. - : Springer Science and Business Media LLC. - 2363-7005 .- 1867-0202. ; 57:1, s. 15-25
  • Tidskriftsartikel (refereegranskat)abstract
    • The need for organizations to operate in changing environments is addressed by proposing an approach that integrates organizational development with information system (IS) development taking into account changes in the application context of the solution. This is referred to as Capability Driven Development (CDD). A meta-model representing business and IS designs consisting of goals, key performance indicators, capabilities, context and capability delivery patterns, is being proposed. The use of themeta-model is validated in three industrial case studies as part of an ongoing collaboration project, whereas one case is presented in the paper. Issues related to the use of the CDD approach, namely, CDD methodology and tool support are also discussed.
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  • Conceptual Modeling : Proceedings
  • 2015
  • Proceedings (redaktörskap) (refereegranskat)abstract
    • This book constitutes the refereed proceedings of the 34th International Conference on Conceptual Modeling, ER 2015, held in Stockholm, Sweden, in October 2015. The 26 full and 19 short papers presented were carefully reviewed and selected from 131 submissions. The papers are organized in topical sections on business process and goal models, ontology-based models and ontology patterns, constraints, normalization, interoperability and integration, collaborative modeling, variability and uncertainty modeling, modeling and visualization of user generated content, schema discovery and evolution, process and text mining, domain-based modeling, data models and semantics, and applications of conceptual modeling.
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  • Jones, Lesley, et al. (författare)
  • Convergent genetic and expression data implicate immunity in Alzheimer's disease
  • 2015
  • Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:6, s. 658-671
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.
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2015 (5)Ta bort avgränsningen

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