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Efficacy of recombi...
Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis.
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Pauli, Gabrielle (författare)
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Larsen, Tina H (författare)
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- Rak, Sabina, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Horak, Friedrich (författare)
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Pastorello, Elide (författare)
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Valenta, Rudolph (författare)
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Purohit, Ashok (författare)
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- Arvidsson, Monica, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Kavina, Alexander (författare)
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Schroeder, Jan W (författare)
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Mothes, Nadine (författare)
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Spitzauer, Susanne (författare)
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Montagut, Armelle (författare)
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Galvain, Sylvie (författare)
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Melac, Michel (författare)
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André, Claude (författare)
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Poulsen, Lars K (författare)
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Malling, Hans-Jorgen (författare)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 122:5, s. 951-60
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition. OBJECTIVE: To evaluate the effectiveness of a new recombinant birch pollen allergen vaccine in patients with birch pollen allergy. METHODS: A multicenter, randomized, double-blind, placebo-controlled trial was undertaken to compare the following 3 vaccines in 134 adults with birch pollen allergy: recombinant birch pollen allergen vaccine (rBet v 1a), licensed birch pollen extract, natural purified birch pollen allergen (nBet v 1), and placebo. Patients received 12 weekly injections followed by monthly injections of the maintenance dose containing 15 microg Bet v 1 for 2 years. RESULTS: Significant reductions (about 50%) in rhinoconjunctivitis symptoms (rBet v 1, P = .0002; nBet v 1, P = .0006; birch extract, P = .0024), rescue medication (rBet v 1, P = .0011; nBet v 1, P = .0025; birch extract, P = .0063), and skin sensitivities (P < .0001) were observed in the 3 actively treated groups compared with placebo during 2 consecutive pollen seasons. Clinical improvement was accompanied by marked increases in Bet v 1-specific IgG levels, which were higher in the rBet v 1-treated group than in the birch and nBet v 1-treated groups. New IgE specificities were induced in 3 of 29 patients treated with birch pollen extract, but in none of the 32 rBet v 1-treated or 29 nBet v 1-treated patients. No severe systemic adverse events were observed in the rBet v 1-treated group. CONCLUSION: The rBet v 1-based vaccine was safe and effective in treating birch pollen allergy, and induced a highly specific immune response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Adult
- Allergens
- adverse effects
- immunology
- Anti-Allergic Agents
- therapeutic use
- Betula
- adverse effects
- immunology
- Conjunctivitis
- Allergic
- immunology
- therapy
- Desensitization
- Immunologic
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Pollen
- adverse effects
- immunology
- Recombinant Proteins
- immunology
- therapeutic use
- Rhinitis
- Allergic
- Seasonal
- immunology
- therapy
- Vaccines
- immunology
- therapeutic use
- Young Adult
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Pauli, Gabrielle
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Larsen, Tina H
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Rak, Sabina, 194 ...
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Horak, Friedrich
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Pastorello, Elid ...
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Valenta, Rudolph
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visa fler...
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Purohit, Ashok
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Arvidsson, Monic ...
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Kavina, Alexande ...
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Schroeder, Jan W
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Mothes, Nadine
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Spitzauer, Susan ...
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Montagut, Armell ...
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Galvain, Sylvie
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Melac, Michel
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André, Claude
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Poulsen, Lars K
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Malling, Hans-Jo ...
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visa färre...
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Göteborgs universitet