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- Aumailley, M, et al.
(författare)
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A simplified laminin nomenclature
- 2005
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Ingår i: Matrix Biology. - : Elsevier BV. - 1569-1802 .- 0945-053X. ; 24:5, s. 326-332
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Forskningsöversikt (refereegranskat)abstract
- A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of 13 chains is named laminin beta-knob (L beta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha IL4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.
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| 2. |
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| 3. |
- Sultan, A., et al.
(författare)
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T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice
- 2009
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Ingår i: Circ Res. - 1524-4571 .- 0009-7330. ; 104:8, s. 961-8
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is associated with chronic inflammation in adipose tissue. Proinflammatory cytokines including tumor necrosis factor-alpha and interleukin-6 secreted by adipose tissue during the metabolic syndrome are proposed to cause local and general insulin resistance and promote development of type 2 diabetes. We have used a compound mutant mouse, Apoe(-/-)xCD4dnTGFbR, with dysregulation of T-cell activation, excessive production of proinflammatory cytokines, hyperlipidemia, and atherosclerosis, to dissect the role of inflammation in adipose tissue metabolism. These mice are lean, which avoids confounding effects of concomitant obesity. Expression and secretion of a set of proinflammatory factors including tumor necrosis factor-alpha, interferon-gamma, and monocyte chemoattractant protein-1 was increased in adipose tissue of Apoe(-/-)xCD4dnTGFbR mice, as was the enzyme 11beta-hydroxysteroid dehydrogenase type 1, which converts cortisone to bioactive cortisol. Interleukin-6, which has an inhibitory glucocorticoid response element in its promoter, was not upregulated. In spite of intense local inflammation, insulin sensitivity was not impaired in adipose tissue of Apoe(-/-)xCD4dnTGFbR mice unless exogenous interleukin-6 was administered. In conclusion, T-cell activation causes inflammation in adipose tissue but does not lead to insulin resistance in this tissue in the absence of interleukin-6.
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| 4. |
- Andersson, A., et al.
(författare)
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FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns
- 2008
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Ingår i: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 47:1, s. 64-70
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Tidskriftsartikel (refereegranskat)abstract
- During 1995-2004, 209 children/adolescents were diagnosed with acute lymphoblastic or myeloid leukemia (ALL, AML) in Southern Sweden, of which 177 (85%), comprising 128 B-lineage ALL, 34 AML, and 15 T-cell ALL, could be analyzed for internal tandem duplications (ITD) and activating point mutations in the second tyrosine kinase domain (ATKD) of FLT3. Seventeen (10%) FLT3 mutations (6 ITD, 11 ATKD, mutually exclusive) were detected. None of the T-cell ALL harbored any mutations. ITD and ATKD were found in 2% and 6% of the B-lineage ALL and in 12% and 9% of the AML, being particularly common in high hyperdiploid ALL (14%), ALL (20%), and AML (23%) with 11q23/MLL rearrangements, and in AML with a normal karyotype (60%). All ATKD-positive AML with MLL rearrangements harbored the t(9,11)(p21,q23). Global gene expression data were available for 76 of the B-lineage ALL and 19 of the AML, of which 6 (8%) and 3 (16%) had FLT3 mutations, respectively. No distinct expression pattern associated with FLT3 mutations was identified. © 2007 Wiley-Liss, Inc.
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| 8. |
- Hemmingsson, Helena, et al.
(författare)
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Sleep problems and the need for parental night-time attention in children with physical disabilities
- 2009
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Ingår i: Child Care Health and Development. - Oxford : Blackwell Publishing. - 0305-1862 .- 1365-2214. ; 35:1, s. 89-95
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Tidskriftsartikel (refereegranskat)abstract
- Background: The aim of the study was to investigate the frequency and predictors of sleep problems and the need for parental night-time attention in children with physical disabilities.Methods: A questionnaire on sleep problems and need for parental night-time attention was completed by 505 parents of children with physical disabilities aged 1-16 years (mean 9 years 3 months) with moderate to severe motor disabilities. General characteristics of the children were analysed by frequencies and cross-tabulations. Logistic regression analysis was used to identify factors associated with sleep problems and the need for parental night-time attention.Results: The results showed a high prevalence of sleep problems, which in general were chronic. Currently 48% of the children had sleep problems, of which 23% estimated the problems to be serious. About one-third (37%) needed parental night-time attention every night, and 10% needed help five times or more. No significant differences were found between younger children and school-aged children regarding sleep problems and the need for parental night-time attention. Having pain [odds ratio (OR)=3.4]was associated with sleep problems, as was having problems eating and drinking (OR=3) and the diagnosis of cerebral palsy (OR=2.5) (P<0.05). Children with muscular dystrophy (OR=68.5), cerebral palsy (OR=26.7) and 'other diagnosis' (OR=18.5) were more likely to need support at night than were children with spina bifida, P<0.001. Pain (OR=7.6) was also associated with need for support at night, P<0.001.Conclusions: The prevalence of sleep problems and need for parental night-time attention is high among children with physical disabilities. This in turn affects the whole family, and paediatric caregivers must keep this in mind. Besides certain diagnoses, the results suggest that children who have pain should be prioritized.
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| 9. |
- Jason, Johan, et al.
(författare)
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Fibre-to-the-Sensor - Blown Fibre Technology in Fibre-Optic Sensor Networks
- 2007
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Ingår i: NOC 2007 Proceedings : 12th European Conference on Networks and Optical Communications incorporating papers of Conference on Optical Cabling and Infrastructure - OC & I. - Kista-Stockholm : Acreo. ; , s. 649-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper the use of blown fibre technology in fibre-optic sensing is discussed. Starting with a background in sensor network topologies and distributed sensor technology, realised and potential applications in industry and society are presented and discussed. The examples mentioned suggest blown fibre as an attractive approach when planning and installing a fibre-optic sensor network. Also, blown distributed fibre sensor units are proposed for use in existing microduct infrastructure.
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