| 1. |
- Andre, M., et al.
(författare)
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Multi-spacecraft observations of broadband waves near the lower hybrid frequency at the Earthward edge of the magnetopause
- 2001
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 19:12-okt, s. 1471-1481
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Tidskriftsartikel (refereegranskat)abstract
- Broadband waves around the lower hybrid frequency (around 10 Hz) near the magnetopause are studied, using the four Cluster satellites. These waves are common at the Earthward edge of the boundary layer, consistent with earlier observations, and can have amplitudes at least up to 5 mV/m. These waves are similar on all four Cluster satellites, i.e. they are likely to be distributed over large areas of the boundary. The strongest electric fields occur during a few seconds, i.e. over distances of a few hundred km in the frame of the moving magnetopause, a scale length comparable to the ion gyroradius. The strongest magnetic oscillations in the same frequency range are typically found in the boundary layer, and across the magnetopause. During an event studied in detail, the magnetopause velocity is consistent with a large-scale depression wave, i.e. an inward bulge of magnetosheath plasma, moving tailward along the nominal magnetopause boundary. Preliminary investigations indicate that a rather flat front side of the large-scale wave is associated with a rather static small-scale electric field, while a more turbulent backside of the large-scale wave is associated with small-scale time varying electric field wave packets.
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| 2. |
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| 3. |
- Castro-Tirado, A. J., et al.
(författare)
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GRB 030227 : The first multiwavelength afterglow of an INTEGRAL GRB
- 2003
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 411:1, s. 315-319
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Tidskriftsartikel (refereegranskat)abstract
- We present multiwavelength observations of a gamma-ray burst detected byINTEGRAL (GRB 030227) between 5.3 hours and ~ 1.7days after the event. Here we report the discovery of a dim opticalafterglow (OA) that would not have been detected by many previoussearches due to its faintess (R ~ 23). This OA was seen to declinefollowing a power law decay with index alpha R = -0.95 +/-0.16. The spectral index beta_ opt/NIR yielded -1.25 +/- 0.14. Thesevalues may be explained by a relativistic expansion of a fireball (withp = 2.0) in the cooling regime. We also find evidence for inverseCompton scattering in X-rays.Based on observations with INTEGRAL, an ESA project with instruments andscience data centre funded by ESA member states (especially the PIcountries: Denmark, France, Germany, Italy, Switzerland, Spain), CzechRepublic and Poland, and with the participation of Russia and the USA.Also partially based on observations collected by the Gamma-Ray BurstCollaboration at ESO (GRACE) at the European Southern Observatory, Chile(ESO Large Programme 165.H-0464).
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| 4. |
- Bruneton, M., V. Farra, H. A. Pedersen & the SVEKALAPKO Seismic Tomography Working Group, (G. Bock, U. Achauer, A. Alinaghi, J. Ansorge, M. Bruneton, W. Friederich, M. Grad, A. Guterch, S.-E. Hjelt, T. Hyvönen, J.-P. Ikonen, E. Kissling, K. Komminaho, A.
(författare)
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Non-linear surface wave phase velocity inversion based on ray theory.
- 2002
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Ingår i: Geophys. J. Int. ; 151, s. 583-596
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Cleland, J. G., et al.
(författare)
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A description of the clinical characteristics at baseline of patients recruited into the Carvedilol or Metoprolol European Trial (COMET)
- 2004
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Ingår i: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. - 0920-3206. ; 18:2, s. 139-52
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: The COMET trial was a prospective, double-blind, randomised trial comparing carvedilol, a comprehensive adrenergic receptor antagonist, with metoprolol, a beta-1-selective agent in patients with heart failure and left ventricular systolic dysfunction. The trial showed a reduction in mortality with carvedilol that was consistent across subgroups. The purpose of this report is to describe in greater detail the heterogeneity of this population at baseline with particular reference to the impact of symptomatic severity, age and gender on patient characteristics. METHODS: A descriptive report using data entered in the COMET study data-base. RESULTS: The characteristics of the population studied were similar to those reported in previous trials of beta-blockers. Almost all patients were receiving diuretics and ACE inhibitors with few patients taking angiotensin receptor blockers. As expected, older patients had more co-morbidity. Older patients and women reported worse symptoms and poorer well-being despite similar ventricular dimensions and systolic dysfunction. NT-proBNP was higher in patients with more severe symptoms and older patients but not in women, although differences in NT-proBNP may have been confounded by differences in renal function. CONCLUSION: Age and gender, as well as the severity of cardiac dysfunction, appear to have an important effect on the severity of heart failure symptoms and patient 'well-being'. This could have important implications for the relationship between symptoms and prognosis and therefore the way in which patients are selected for clinical trials and the goals of treatment. This will be the subject of further analyses.
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| 6. |
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| 7. |
- Laakso, H., Grard, R., Masson, A., Moullard, O., Bale, S., Mozer, F., Pedersen, A., Andre, M., Eriksson, A., Gustaffson, G. and Lindqvist, P.-A.
(författare)
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Multi-point electric field observations in the high-latitude magnetosphere
- 2001
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Ingår i: Les Woolliscroft Memorial Conference Sheffield Space Plasma Meeting: Multipoint Measurements versus Theory. Proceedings (SP-492) (2001) ESA SP-492. - : Noordwijk, Netherlands. ; , s. 27-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The authors use multi-point electric field observations from the four Cluster satellites to study the dynamical behavior of the high-latitude magnetosphere on February 13-14, 2001, 20-02 UT. At 20:00 UT the vehicles enter the cusp where three satellites o
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| 8. |
- Pedersen, A., Decreau, P., Escoubet, C.P., Gustafsson, G., Laakso, H., Lindqvist, P.-A. , Lybekk, B., Masson, A., Mozer, F. and Vaivads, A.
(författare)
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Four-point high time resolution information on electron densities by the electric field experiments (EFW) on Cluster.
- 2001
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Ingår i: Annales Geophysicae. ; 19:6, s. 1483-1489
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Tidskriftsartikel (refereegranskat)abstract
- For accurate measurements of electric fields spherical double probes are electronically controlled to be at a positive potential of approximately 1 volt relative to the ambient magnetospheric plasma. The spacecraft will acquire a potential which balance
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| 9. |
- Sandén, Anna Maria, et al.
(författare)
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Limiting factors in Escherichia coli fed-batch production of recombinant proteins
- 2003
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Ingår i: Biotechnology and Bioengineering. - : Wiley. - 0006-3592 .- 1097-0290. ; 81:2, s. 158-166
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Tidskriftsartikel (refereegranskat)abstract
- Fed-batch production of recombinant beta-galactosidase in E. coli was studied with respect to the specific growth rate at induction. The cultivations were designed to induce protein production by IPTG at a glucose feed rate corresponding to high (mu = 0.5 h(-1)) or low (mu = 0.1 h(-1)) specific growth rate. Protein production rate was approximately 100% higher at the higher specific growth rate, resulting in the accumulation of beta-galactosidase up to 30% of the total cell protein. Transcription analysis showed that beta-galactosidase-specific messenger RNA was immediately formed after induction (<5 min), but the amount was the same in both cases and was thus not the initial limiting factor. The content of ribosomes, as represented by rRNA, rapidly decreased with specific growth rate from a relative level of 100%, at the high specific growth rate, to 20% at the low specific growth rate. At high specific growth rate, ribosomes were additionally degraded upon induction due to the high production level. Translation therefore seemed to be the initial limiting factor of the protein synthesis capacity. The alarmone guanosine tetraphosphate increased at both high and low feed level inductions, indicating an induction-forced starvation of charged tRNA and/or glucose. The altered physiological status was also detected by the formation of acetic acid. However, the higher production rate resulted in high-level accumulation of acetic acid, which was absent at low feed rate production. Acetic acid production is thus coupled to the high product formation rate and is proposed to be due either to a precursor drain of Krebs cycle intermediates and a time lag before induction of the glyoxalate shunt, or to single amino acid overflow, since the model product is relatively poor in glycin and alanin. In conclusion, it is proposed that production at high specific growth rate becomes precursor-limited, while production at low specific growth rate is carbon- and/or energy-limited.
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| 10. |
- Bock G., Roberts R.G., Kissling E., Achauer A., Alingahi J., Bruneton M., Friedrich W., Grad M. Guterch A., Hjelt S-E., Hyvönen T., Ikonen J-P., Komminaho K., Korja A, Heikkinen P., Kozolovaskaya E., Nevsky M.V., Pavlenkova N., Pedersen H., Plomerova J.
(författare)
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Seismic probing of Archean and Proterozoic Lithosphere in Fennoscandia.
- 2001
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Ingår i: EOS Transactions American Geophysical Union. - : American Geophysical Union. ; 82, s. 621,628-629
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Tidskriftsartikel (refereegranskat)
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