| 1. |
- Moayyeri, Alireza, et al.
(författare)
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Genetic determinants of heel bone properties : genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:11, s. 3054-3068
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Tidskriftsartikel (refereegranskat)abstract
- Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 x 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 x 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 x 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.
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| 2. |
- Beswick, R. J., et al.
(författare)
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SKA studies of nearby galaxies: Star-formation, accretion processes and molecular gas across all environments
- 2014
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Ingår i: Proceedings of Science. - 1824-8039. ; 9-13-June-2014
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Konferensbidrag (refereegranskat)abstract
- The SKA will be a transformational instrument in the study of our local Universe. In particular, by virtue of its high sensitivity (both to point sources and diffuse low surface brightness emission), angular resolution and the frequency ranges covered, the SKA will undertake a very wide range of astrophysical research in the field of nearby galaxies. By surveying vast numbers of nearby galaxies of all types with mJy sensitivity and sub-arcsecond angular resolutions at radio wavelengths, the SKA will provide the cornerstone of our understanding of star-formation and accretion activity in the local Universe. In this chapter we outline the key continuum and molecular line science areas where the SKA, both during phase-1 and when it becomes the full SKA, will have a significant scientific impact.
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| 3. |
- Altenkirch, J., et al.
(författare)
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Comparison of methods to determine variations in unstrained unit cell parameter across welds
- 2011
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Ingår i: Journal of Strain Analysis for Engineering Design. - : SAGE Publications. - 0309-3247 .- 2041-3130. ; 46:7, s. 651-662
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Tidskriftsartikel (refereegranskat)abstract
- Many alloys undergo complex changes in local chemistry in the vicinity of weldments due to the thermal excursion during welding. The resulting changes in solute concentrations can lead to significant local variations in the unstrained unit cell parameter which, if not accounted for, can lead to serious error when determining residual stress by diffraction methods. Age-hardening aluminium alloys are particularly susceptible to such effects. The present paper compares three methods (plane stress assumption, sin(2)psi method, and comb correction method) for evaluating the stress-free unit cell parameter variation for friction stir welds in AA7449-W51 plates of two different thicknesses. All three methods gave comparable results for thin (5 mm) sheet, but for the thicker (12.2 mm) plate the results calculated on the basis of the plane stress assumption diverged from the other two, largely because in this case the other methods indicate there to be a significant triaxiality of stress. In the example cases, hardness and unstrained unit cell parameter variations were found to be strongly correlated across the welds. The advantages and disadvantages of the three methods are compared.
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| 4. |
- Ebbestad, Jan Ove R., et al.
(författare)
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Biogeography of Ordovician and Silurian gastropods, monoplacophorans and mimospirids
- 2013
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Ingår i: Memoir Geological Society of London. - London : The Geological Society of London. - 9781862393738 ; 38, s. 199-220
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Tidskriftsartikel (refereegranskat)abstract
- The biogeographical distribution of Ordovician and Silurian gastropods, monoplacophorans and mimospirids has beenanalysed on a generic level. The dataset contains 334 genera and 2769 species, yielding 1231 records of genera with 2274 occurrencesworldwide. There is a bias towards eastern Laurentia, Baltica and Perunica records. Some 53.1% of the records are Ordovician. The study demonstrates that these molluscs are well suited to being used to improve understanding of Ordovician and Silurian biogeographicalprovinciality. Specific points are that: a Lower Ordovician assemblage is evident in Laurentia; the fauna of the Argentinean Precordillera is Laurentian until the Darriwilian, when taxa are shared with North China; Late Silurian gastropods from the Alexander terrane (SE Alaska) are unknown in Laurentia, but support a rift origin of this terrane from NE Siberia; Perunica, Ibero-Armorica and Morocco cluster together throughout the Ordovician but Perunica and Morocco are closer; Darriwilian–Sandbian deep-water Bohemian taxaoccur in Baltica; a Laurentian–Baltica proximity is unsupported until the Silurian; Siberia clusters with North China and eastern Laurentia during the Tremadocian–Darriwilian; during the Gorstian–Pridoli Siberia clusters with the Farewell and Alexander terranes; North China may have been close to Laurentia and the Argentinean margin of Gondwana; and the affinity of Tarim taxa is problematic.
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| 5. |
- Kouchinsky, Artem, et al.
(författare)
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A Middle Cambrian fauna of skeletal fossils from the Kuonamka Formation, northern Siberia.
- 2011
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Ingår i: Alcheringa. - : Informa UK Limited. - 0311-5518 .- 1752-0754. ; 35:1, s. 123-189
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Tidskriftsartikel (refereegranskat)abstract
- An assemblage of mineralized skeletal fossils containing molluscs, hyoliths, chancelloriids, protoconodonts, lobopods, paleoscolecids, bradoriids, echinoderms and hexactinellid sponges is described from the middle Cambrian part of the Kuonamka Formation, exposed along the Malaya Kuonamka and Bol’shaya Kuonamka rivers, northern Siberian Platform. The sampled succession is attributed to the Kuonamkites and lower Tomagnostus fissus–Paradoxides sacheri biozones of the Amgan Stage of Siberia, correlated with Series 3, Stage 5—lower Drumian Stage of the IUGS chronostratigraphical scheme for the Cambrian. This work complements descriptions of molluscs from the same samples published by Gubanov et al. (2004) with additional material. It contains forms in common with coeval faunas from Australia, China, Western Gondwana, Avalonia, Laurentia and Baltica, increasing potential for global biostratigraphic correlation and understanding of palaeogeographic connections.
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| 6. |
- Larsson, Cecilia M
(författare)
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Early Cambrian Problematic Lophotrochozoans and Dilemmas of Scleritome Reconstructions
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The emergence and radiation of metazoan body plans around the Precambrian/Cambrian boundary, some 500-600 million years ago, seems to be concordant with the appearance and diversification of preservable hard parts. Several Precambrian soft-bodied, multicellular organisms most likely represent stem-group bilaterians, but their fossil record is rather sparse. In contrast, the Cambrian fossil record is comparably rich – comprising hard part, trace fossil and delicate soft tissue preservation – and most animal phyla that we know of today had evolved by the end of the Cambrian. Consequently, this time represents an important period in the early evolution of metazoan life forms. Most skeletal remnants of invertebrate organisms from this period are preserved in incomplete, disarticulated sclerite assemblages, and the true architecture of the original skeletal structure, the scleritome, may therefore be hard to discern. Many scleritomous taxa have been suggested to be members of the lophotrochozoan clade, while their exact position within this group remains unclear. Such taxa are often referred to as Problematica. This thesis deals with some problematic scleritomous early Cambrian lophotrochozoans, and as such also addresses the dilemmas of scleritome reconstructions. In the first part, completely disarticulated calcareous sclerites from the lower Cambrian of North Greenland are described as Trachyplax arctica. Hypothetical scleritome reconstruction alternatives and comparisons to other scleritome-bearing taxa are discussed, but the lack of articulated material obscures any satisfactory conclusions regarding phylogenetic affinities and the original morphology of the organism. The other part of the thesis focuses on some minute, organophosphatic scleritomous metazoans, tommotiids, found in lower Cambrian limestone successions in South Australia – Paterimitra pyramidalis and Kulparina rostrata – their scleritome architecture and their phylogenetic relationship with paterinid brachiopods. The oldest brachiopod from South Australia, Askepasma saproconcha, and the slightly younger Askepasma toddense are also described and discussed. Based on articulated specimens, recently described partial scleritomes of the tommotiid Eccentrotheca helenia and similarities in shell ultrastructure with both Eccentrotheca and Askepasma, Paterimitra is interpreted as a stem-group brachiopod and reconstructed as a bilaterally symmetrical, sessile, filter feeder with a tubular/conical scleritome. The morphological similarities with Paterimitra point in the same direction for the slightly older Kulparina.
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