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Helicobacter pylori...
Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study
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- Huang, Jiaqi (författare)
- Karolinska Institute
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- Zagai, Ulrika (författare)
- Karolinska Institutet,Karolinska Institute
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- Hallmans, Göran (författare)
- Umeå universitet,Umeå University,Institutionen för kostvetenskap
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- Nyrén, Olof (författare)
- Karolinska Institute
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- Engstrand, Lars (författare)
- Karolinska Institutet,Karolinska Institute
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- Stolzenberg-Solomon, Rachael (författare)
- National Cancer Institute, USA
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- Duell, Eric J (författare)
- Catalan Institute of Oncology
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- Overvad, Kim (författare)
- Aarhus University
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- Katzke, Verena A (författare)
- German Cancer Research Centre,Bellvitge University Hospital-IDIBELL
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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- Park, Jin Young (författare)
- International Agency for Research on Cancer, World Health Organization
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- Murillo, Raul (författare)
- International Agency for Research on Cancer, World Health Organization
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Lagiou, Pagona (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens,Harvard University
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- Bamia, Christina (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Bradbury, Kathryn E (författare)
- University of Oxford
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- Riboli, Elio (författare)
- Imperial College London
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- Aune, Dagfinn (författare)
- Imperial College London
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- Tsilidis, Konstantinos K. (författare)
- University of Ioannina,Imperial College London
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- Capellá, Gabriel (författare)
- Catalan Institute of Oncology
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- Agudo, Antonio (författare)
- Bellvitge University Hospital-IDIBELL
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- Krogh, Vittorio (författare)
- Istituto Nazionale dei Tumori
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Karolinska Institute,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Martínez, Begoña (författare)
- Andalusian School Of Public Health (EASP)
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- Redondo-Sanchez, Daniel (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada
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- Chirlaque, Maria Dolores (författare)
- Murcia Regional Health Council,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
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- HM Peeters, Petra (författare)
- University Medical Center Utrecht
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- Regnér, Sara (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Lindkvist, Björn (författare)
- Sahlgrenska University Hospital
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- Naccarati, Alessio (författare)
- Human Genetics Foundation (HuGeF)
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Larrañaga, Nerea (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Boutron-Ruault, Marie-Christine (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Rebours, Vinciane (författare)
- Paris Diderot University
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- Barré, Amélie (författare)
- University of Paris-Saclay
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- Bueno-De-Mesquita, Bas H. (författare)
- National Institute for Public Health and the Environment (RIVM),University of Malaya,Imperial College London,University Medical Center Utrecht
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- Ye, Weimin (författare)
- Karolinska Institutet,Umeå University,Karolinska Institute
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(creator_code:org_t)
- 2017-02-23
- 2017
- Engelska 9 s.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 140:8, s. 1727-1735
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- chronic corpus atrophic gastritis
- EPIC cohort
- H. pylori infection
- nested case-control study
- pancreatic cancer risk
- H. pylori infection
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Huang, Jiaqi
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Zagai, Ulrika
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Hallmans, Göran
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Nyrén, Olof
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Engstrand, Lars
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Stolzenberg-Solo ...
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visa fler...
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Duell, Eric J
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Overvad, Kim
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Katzke, Verena A
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Kaaks, Rudolf
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Jenab, Mazda
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Park, Jin Young
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Murillo, Raul
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Trichopoulou, An ...
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Lagiou, Pagona
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Bamia, Christina
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Bradbury, Kathry ...
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Riboli, Elio
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Aune, Dagfinn
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Tsilidis, Konsta ...
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Capellá, Gabriel
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Agudo, Antonio
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Krogh, Vittorio
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Palli, Domenico
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Panico, Salvator ...
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Weiderpass, Elis ...
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Tjønneland, Anne
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Olsen, Anja
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Martínez, Begoña
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Redondo-Sanchez, ...
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Chirlaque, Maria ...
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HM Peeters, Petr ...
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Regnér, Sara
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Lindkvist, Björn
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Naccarati, Aless ...
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Ardanaz, Eva
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Larrañaga, Nerea
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Boutron-Ruault, ...
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Rebours, Vincian ...
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Barré, Amélie
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Bueno-De-Mesquit ...
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Ye, Weimin
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