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IL-9 Governs Allerg...
IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways
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Kearley, Jennifer (author)
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- Erjefält, Jonas (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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- Andersson, Cecilia (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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Benjamin, Ebony (author)
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Jones, Carla P. (author)
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Robichaud, Annette (author)
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Pegorier, Sophie (author)
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Brewah, Yambasu (author)
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Burwell, Timothy J. (author)
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- Bjermer, Leif (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kiener, Peter A. (author)
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Kolbec, Roland (author)
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Lloyd, Clare M. (author)
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Coyle, Anthony J. (author)
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Humbles, Alison A. (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: American Journal of Respiratory and Critical Care Medicine. - 1535-4970. ; 183:7, s. 865-875
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Rationale: IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. Objectives: The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier studies focused on the role of IL-9 in acute inflammatory models; here we have investigated the effects of IL-9 blockade during chronic allergic inflammation. Methods: Mice were exposed to either prolonged ovalbumin or house dust mite allergen challenge to induce chronic inflammation and airway remodeling. Measurements and Main Results: We found that IL-9 governs allergen-induced mast cell (MC) numbers in the lung and has pronounced effects on chronic allergic inflammation. Anti-IL-9 antibody-treated mice were protected from airway remodeling with a concomitant reduction in mature MC numbers and activation, in addition to decreased expression of the profibrotic mediators transforming growth factor-beta 1, vascular endothelial growth factor, and fibroblast growth factor-2 in the lung. Airway remodeling was associated with impaired lung function in the peripheral airways and this was reversed by IL-9 neutralization. In human asthmatic lung tissue, we identified MCs as the main IL-9 receptor expressing population and found them to be sources of vascular endothelial growth factor and fibroblast growth factor-2. Conclusions: Our data suggest an important role for an IL-9-MC axis in the pathology associated with chronic asthma and demonstrate that an impact on this axis could lead to a reduction in chronic inflammation and improved lung function in patients with asthma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- IL-9
- mast cells
- asthma
- airway remodeling
- AHR
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kearley, Jennife ...
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Erjefält, Jonas
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Andersson, Cecil ...
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Benjamin, Ebony
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Jones, Carla P.
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Robichaud, Annet ...
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show more...
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Pegorier, Sophie
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Brewah, Yambasu
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Burwell, Timothy ...
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Bjermer, Leif
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Kiener, Peter A.
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Kolbec, Roland
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Lloyd, Clare M.
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Coyle, Anthony J ...
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Humbles, Alison ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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American Journal ...
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Lund University