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Hyperparathyroidism...
Hyperparathyroidism associated with treatment of manic-depressive disorders by lithium.
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- Nordenström, J (author)
- Department of Surgery, Huddinge University Hospital, Sweden
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- Strigård, Karin (author)
- Department of Surgery, Huddinge University Hospital, Sweden
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Perbeck, L (author)
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Willems, J (author)
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Bågedahl-Strindlund, M (author)
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Linder, J (author)
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(creator_code:org_t)
- 1992
- 1992
- English.
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In: European Journal of Surgery. - 1102-4151 .- 1741-9271. ; 158:4, s. 207-211
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- OBJECTIVE: To clarify the association between treatment of affective psychiatric disorders with lithium, and the development of secondary hyperparathyroidism.DESIGN: Retrospective review of medical records, 1973-89.SUBJECTS: 17 patients with affective psychiatric disorders who were treated with lithium (n = 6) or with tricyclic antidepressant, or neuroleptic, drugs (n = 11) all of whom were operated on for hyperparathyroidism.MAIN OUTCOME MEASURE: Duration of lithium therapy and parathyroid histology.RESULTS: Parathyroid hyperplasia was present in 5 patients who had taken lithium during a median period of 13 years. A parathyroid adenoma was found in one patient treated with lithium for three years. Ten of the 11 patients who had been treated with tricyclic antidepressant, or neuroleptic drugs had a parathyroid adenoma and the remaining one had an adenoma as an underlying cause of hyperparathyroidism.CONCLUSION: Hyperparathyroidism in patients who have undergone long term treatment with lithium is associated with parathyroid hyperplasia. This indicates that lithium may exert a chronic stimulus that results in secondary hyperparathyroidism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Hyperparathyriodism
- Lithium therapy
- manic depressive disorder
Publication and Content Type
- ref (subject category)
- art (subject category)
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