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Träfflista för sökning "WFRF:(Pereira Paulo) srt2:(2007-2009)"

Sökning: WFRF:(Pereira Paulo) > (2007-2009)

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1.
  • Franklin, Bernardo S., et al. (författare)
  • Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function
  • 2009
  • Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 106:14, s. 5789-5794
  • Tidskriftsartikel (refereegranskat)abstract
    • Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mechanisms by which malaria mediates TLR hyperresponsiveness are unclear. Here we show that TLR responses are boosted in febrile patients during natural infection with P. falciparum. Microarray analyses demonstrated that an extraordinary percentage of the up-regulated genes, including genes involving TLR signaling, had sites for IFN-inducible transcription factors. To further define the mechanism involved in malaria-mediated "priming,'' we infected mice with Plasmodium chabaudi. The human data were remarkably predictive of what we observed in the rodent malaria model. Malaria-induced priming of TLR responses correlated with increased expression of TLR mRNA in a TLR9-, MyD88-, and IFN gamma-dependent manner. Acutely infected WT mice were highly susceptible to LPS-induced lethality while TLR9(-/-), IL12(-/-) and to a greater extent, IFN gamma(-/-) mice were protected. Our data provide unprecedented evidence that TLR9 and MyD88 are essential to initiate IL12 and IFN gamma responses and favor host hyperresponsiveness to TLR agonists resulting in overproduction of proinflammatory cytokines and the sepsis-like symptoms of acute malaria.
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2.
  • Nunes, Renato, et al. (författare)
  • Tools and methods for systematic WSAN engineering
  • 2009
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The goal of this deliverable is to research an application-centric communication system engineering framework that supports system engineers in analysing and defining requirements as well as providing tool support during the selection of particular network mechanisms to be used within the WSAN under development. For this purpose we present a general design flow to help engineering WSAN applications. The semantic centreis a knowledge base it allows to describe requirements, environment, components and the whole system. The presented model-driven scheme as part of the component description is able to predict the properties of theoverall system based on static properties of components in context of the given environment. For more complex dynamic properties a novel simulation approach is presented that combines network simulations with actual properties of the operating system and the software stack. Operations of the development flow are supported by various tools. First examples indicate the effectiveness of the proposed design flow and promiseto improve engineering of WSAN system in future.
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