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Hepatic steatosis, ...
Hepatic steatosis, metabolic dysfunction and risk of mortality : findings from a multinational prospective cohort study
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- Mayén, Ana-Lucia (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Sabra, Mirna (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Aglago, Elom K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Perlemuter, Gabriel (författare)
- INSERM U996, DHU HepatinovLabex LERMIT, Intestinal Microbiota, Clamart, France; Faculté de Médecine Paris-Sud, Univ Paris-Sud, Université Paris-Saclay ,Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France
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- Voican, Cosmin (författare)
- INSERM U996, DHU HepatinovLabex LERMIT, Intestinal Microbiota, Clamart, France; Faculté de Médecine Paris-Sud, Univ Paris-Sud, Université Paris-Saclay ,Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France
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- Ramos, Ines (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Debras, Charlotte (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Blanco, Jessica (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Viallon, Vivian (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Ferrari, Pietro (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Olsen, Anja (författare)
- Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark
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- Langmann, Fie (författare)
- Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark
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- Dahm, Christina C. (författare)
- Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark
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- Rothwell, Joseph (författare)
- UVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
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- Laouali, Nasser (författare)
- UVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
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- Marques, Chloé (författare)
- UVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
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- Schulze, Matthias B. (författare)
- Dept. of Molecular Epidemiology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany
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- Katzke, Verena (författare)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Macciotta, Alessandra (författare)
- Department of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, Public Health (C-BEPH), University of Turin, Turin, Italy
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- Panico, Salvatore (författare)
- Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy
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- Tumino, Rosario (författare)
- Hyblean Association for Epidemiological Research, Ragusa, Italy
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- Agnoli, Claudia (författare)
- Department of Research Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
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- Farràs, Marta (författare)
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
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- Molina-Montes, Esther (författare)
- Department of Nutrition and Food Science, Campus of Cartuja, University of Granada, Granada, Spain; Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; Institute of Nutrition and Food Technology (INYTA) 'José Mataix', Biomedical Research Centre, University of Granada, Granada, Spain
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- Amiano, Pilar (författare)
- Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain
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- Chirlaque, María-Dolores (författare)
- Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
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- Castilla, Jesús (författare)
- Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Navarra Public Health Institute - IdiSNA, Pamplona, Spain
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- Werner, Mårten (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Bodén, Stina (författare)
- Umeå universitet,Pediatrik
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- Heath, Alicia K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Tsilidis, Kostas (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Aune, Dagfinn (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevål, Oslo, Norway
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- Weiderpass, Elisabete (författare)
- Office of the Director, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Freisling, Heinz (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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- Gunter, Marc J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Jenab, Mazda (författare)
- Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France
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(creator_code:org_t)
- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 22:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD and MetS with overall and cause-specific mortality.METHODS: We used dietary, lifestyle, anthropometric and metabolic biomarker data from a random subsample of 15,784 EPIC cohort participants. NAFLD was assessed using the fatty liver index (FLI) and MetS using the revised definition. Indices for metabolic dysfunction-associated fatty liver disease (MAFLD) were calculated. The individual associations of these indices with overall and cause-specific mortality were assessed using multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs). As a subobjective, risk associations with adaptations of new classifications of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic and alcohol-related liver disease (MetALD) were also assessed.RESULTS: Among the 15,784 sub-cohort participants, a total of 1997 deaths occurred (835 due to cancer, 520 to CVD, 642 to other causes) over a median 15.6 (IQR, 12.3-17.1) years of follow-up. Compared to an FLI < 30, FLI ≥ 60 was associated with increased risks of overall mortality (HR = 1.44, 95%CI = 1.27-1.63), and deaths from cancer (HR = 1.32, 95%CI = 1.09-1.60), CVD (HR = 2.06, 95% CI = 1.61-2.63) or other causes (HR = 1.21, 95%CI = 0.97-1.51). Mortality risk associations were also elevated for individuals with MAFLD compared to those without. Individuals with MetS were at increased risk of all mortality endpoints, except cancer-specific mortality. MASLD and MetALD were associated with higher risk of overall mortality.CONCLUSIONS: Our findings based on a prospective cohort suggest that individuals with hepatic steatosis or metabolic dysfunction have a higher overall and cause-specific mortality risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Hepatic steatosis
- MAFLD
- Metabolic syndrome
- Mortality
- Phenotypic NASH
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Mayén, Ana-Lucia
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Sabra, Mirna
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Aglago, Elom K.
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Perlemuter, Gabr ...
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Voican, Cosmin
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Ramos, Ines
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visa fler...
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Debras, Charlott ...
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Blanco, Jessica
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Viallon, Vivian
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Ferrari, Pietro
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Olsen, Anja
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Tjønneland, Anne
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Langmann, Fie
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Dahm, Christina ...
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Rothwell, Joseph
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Laouali, Nasser
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Marques, Chloé
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Schulze, Matthia ...
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Katzke, Verena
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Kaaks, Rudolf
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Palli, Domenico
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Macciotta, Aless ...
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Panico, Salvator ...
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Tumino, Rosario
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Agnoli, Claudia
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Farràs, Marta
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Molina-Montes, E ...
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Amiano, Pilar
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Chirlaque, María ...
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Castilla, Jesús
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Werner, Mårten
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Bodén, Stina
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Heath, Alicia K.
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Tsilidis, Kostas
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Aune, Dagfinn
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Weiderpass, Elis ...
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Freisling, Heinz
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Gunter, Marc J.
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Jenab, Mazda
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