| 1. |
- Persson, Gunilla Almström, 1959-
(författare)
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Perspektiv i polisprotokoll
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The subject of this study is perspective in police reports. The overall aim is to introduce new tools for analysing perspective in written narratives. The material consists of reports based on different accounts of the same conflict from a number of people (the suspect, the injured part and witnesses), that is, different versions of the same sequence of events. The study begins with a theoretical discussion of perspective in literary texts and of some characteristics of the police reports examined. Two tools are developed to analyse linguistic means for identifying perspective.The first analytical tool can be placed within the framework of cognitive semantics. Analysis here concerns seeing space differently and having different limits in one’s way of experiencing the sequence of events. This conceptualisation of the focaliser (the person whose perspective is reported) is realised in the text through certain spatial expressions associated with the concept of centre. To analyse the centres chosen, the image schema centre–periphery is used in examining instances of the adverbs fram and bort and their derivations.The second analytical tool can be placed within the theoretical framework of dramaturgy. Analysis here concerns perceiving the dramatic development of events differently, that is, dramatic patterns in the different versions of the conflict and which character is given the most active role in it. The differences can be seen in the focaliser’s choice of events and how aggression is consciously or unconsciously described in terms of how different characters cause the conflict to escalate.The hypothesis being tested is whether the suspect’s perspective is discernible in the report of the suspect’s account. The hypothesis is confirmed. The study shows that the tools introduced work successfully in the analysis of perspective. Both analyses yield results, which in both cases can be validated.
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| 2. |
- Holm, Caroline, et al.
(författare)
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Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia
- 2006
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Ingår i: Leukemia Research. - : Elsevier. - 0145-2126 .- 1873-5835. ; 30:3, s. 254-261
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Tidskriftsartikel (refereegranskat)abstract
- A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%).
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| 3. |
- Wegiel, Barbara, et al.
(författare)
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A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer
- 2005
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Ingår i: Oncogene. - : Nature Publishing Group. - 0950-9232 .- 1476-5594. ; 24:42, s. 6385-6393
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Tidskriftsartikel (refereegranskat)abstract
- Elevated levels of cyclin A1 expression have been implicated in acute myeloid leukemia and in male germ cell tumors. However, a role of cyclin A1 in tumorigenesis of prostate cancer has not been reported. In the present study, expression of cyclin A1 in patients with prostate cancer and a role of cyclin A1 in mediating expression of vascular endothelial growth factor (VEGF) were investigated. Cyclin A1 was highly expressed in aggressive tumors and was significantly correlated with VEGF expression in 96 patients with prostate cancer. Treatment of LNCaP cells with R1881, a synthetic androgen resulted in increased cyclin A1 expression. Induction of cyclin A1 expression in LNCaP cells led to an increase in VEGF expression and this effect was manifested upon the R1881 treatment. Cyclin A1 failed to mediate VEGF activation in DU-145 cells lacking a functional Rb and an androgen receptor (AR). Although AR expression was induced into DU-145 cells, cyclin A1 was unable to mediate VEGF expression. However, induced coexpression of cyclin A1, Rb and AR in DU-145 cells in the presence of R1881 greatly promoted VEGF promoter activity. This suggests that cyclin A1 mediates VEGF expression in cooperation with Rb- and androgen-dependent pathways in prostate cancer.
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