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- Persson, Christina, 1959, et al.
(författare)
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Speech and hearing in adults with 22q11.2 deletion syndrome
- 2012
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Ingår i: American Journal of Medical Genetics. Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 158A:12, s. 3071-3079
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the study was to investigate the prevalence of velopharyngeal impairment, compensatory articulation, reduced intelligibility, and to rate the general impression of speech in adults with 22q11.2 deletion syndrome. The second purpose was to study the prevalence and type of hearing impairment in these adults. A referred, consecutive series of 24 adults with confirmed 22q11.2 deletion, 16 female and 8 males, with a mean age of 25 years (19–38 years) was included in the study. A blind assessment of speech by three experienced speech- language pathologists was performed. Sixteen (66%) patients had a mild to severe velopharyngeal impairment. The most prevalent symptoms of velopharygeal impairment were hypernasality and audible nasal airflow. The mean nasalance score was 33% (6–66%). Only two patients had disordered articulation; one of these had glottal articulation. A mean of 96% (88–100%) of single words were rated to be intelligible. To achieve these results half of the patients previously had velopharyngeal flap surgery. Forty-one percent (9/22) had mild–moderate hearing impairment; three had sensorineural type, four conductive and two had a mixed type. In conclusion the majority of the patients had no articulation errors and good intelligibility; while one-third still had moderate to severe problems with velopharyngeal impairment. Around 40% still had some hearing impairment, in most cases with a mild to moderate conductive component. Thus, a high prevalence of speech and hearing problems seems to be a part of the phenotype in adults with 22q11.2DS. © 2012 Wiley Periodicals, Inc.
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| 2. |
- Flynn, Traci, 1973, et al.
(författare)
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A longitudinal study of hearing and middle ear status of individuals with cleft palate with and without additional malformations/syndromes.
- 2014
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Ingår i: The Cleft Palate-Craniofacial Journal. - : SAGE Publications. - 1055-6656 .- 1545-1569. ; 51:5
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To describe and compare the middle ear status and hearing sensitivity in adolescence with isolated cleft palate plus additional malformations and/or syndromes with those with only an isolated cleft palate. Design: Retrospective and longitudinal. Two groups of individuals with isolated cleft palate were compared. Participants: A cohort of individuals born over 4 years in the western region of Sweden. The cohort was divided into one group with isolated cleft palate (n = 31; ICP) and one group with isolated cleft palate plus additional malformations and/or syndromes (n = 37; ICP+). Methods: Middle ear status and hearing thresholds were collected from the medical records at 7, 10, 13, and 16 years of age, examined, and compared within and between groups over time. Results: The ICP+ group demonstrated a significantly higher prevalence of abnormal middle ear status and elevated hearing thresholds as compared with the ICP group. As the individuals aged, the prevalence of abnormal middle ear status decreased. The hearing levels in both groups decreased in the low to middle frequencies as individuals aged; however, the hearing in the high frequencies did not. Conclusions: Individuals with cleft palate need to be followed routinely for middle ear status and hearing thresholds to ensure optimal audiological rehabilitation, with particular attention to those with additional malformations and/or syndromes.
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| 3. |
- Johannisson, Tove B, et al.
(författare)
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Assessing intelligibility by single words, sentences and spontaneous speech: a methodological study of the speech production of 10-year-olds.
- 2014
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Ingår i: Logopedics, phoniatrics, vocology. - : Informa UK Limited. - 1651-2022 .- 1401-5439. ; 39:4, s. 159-168
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate the impact of different assessment methods on intelligibility scores and to examine the validity and reliability of those methods. Four assessment methods were used: multiple-choice and transcription of single words (read out), transcription of sentences (read out), and spontaneous speech. The results showed a statistically significant difference between outcomes for the different assessment methods. Reliability was high for all methods. Validity was low for all three reading-based methods. The method using transcription of spontaneous speech had low validity for the population included. It was concluded that reading is not a suitable elicitation technique for 10-year-olds and that the assessment procedure used for spontaneous speech needs to be further developed and investigated.
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| 4. |
- Lagerberg, Tove B, et al.
(författare)
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Assessment of intelligibility using children's spontaneous speech: methodological aspects
- 2014
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Ingår i: International journal of language and communication disorders. - : Wiley. - 1368-2822. ; 49:2, s. 228-239
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Tidskriftsartikel (refereegranskat)abstract
- Background Intelligibility is a speaker's ability to convey a message to a listener. Including an assessment of intelligibility is essential in both research and clinical work relating to individuals with communication disorders due to speech impairment. Assessment of the intelligibility of spontaneous speech can be used as an overall indicator of the severity of a speech disorder. There is a lack of methods for measuring intelligibility on the basis of spontaneous speech. Aims To investigate the validity and reliability of a method where listeners transcribe understandable words and an intelligibility score is calculated on the basis of the percentage of syllables perceived as understood. Methods & Procedures Spontaneous speech from ten children with speech-sound disorders (mean age = 6.0 years) and ten children with typical speech and language development (mean age = 5.9 years) was recorded and presented to 20 listeners. Results were compared between the two groups and correlation with percentage of consonants correct (PCC) was examined. Outcomes & Results The intelligibility scores obtained correlated with PCC in single words and differed significantly between the two groups, indicating high validity. Inter-judge reliability, analysed using intra-class correlation (ICC), was excellent in terms of the average measure for several listeners. Conclusions & Implications The results suggest that this method can be recommended for assessing intelligibility, especially if the mean across several listeners is used. It could also be used in clinical settings when evaluating intelligibility over time, provided that the same listener makes the assessments.
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| 5. |
- Palle, Nanna, et al.
(författare)
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The effectiveness of phonological intervention in preschool children: a single-subject design study.
- 2014
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Ingår i: Logopedics, phoniatrics, vocology. - : Informa UK Limited. - 1651-2022 .- 1401-5439. ; 39:1, s. 19-29
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Tidskriftsartikel (refereegranskat)abstract
- The purpose was to investigate an intervention model for treating preschool children with phonological processes. Six children, three girls and three boys, between 4y 1m and 5y 7m, with similar developmental phonological disorder (PD) received an individually adjusted intervention including articulatory, phonological, and meta-phonological approaches. A single-subject multiple-baseline design with /f/ and /s/ as target phonemes and velar plosives and /r/ as control phonemes was used. An improved production of the treated phonemes was found in five of the children, while one girl established /f/ but not /s/. The control phonemes remained unchanged for all children. Six to 18 therapy sessions were needed to reach the intervention goal. The study highlights the importance of considering heterogeneity in children with PD.
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| 6. |
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| 7. |
- Pettersson, Anna, 1979-, et al.
(författare)
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Assessing patients’ perceived bother from the gastrointestinal side effects of radiotherapy for localized prostate cancer : initial questionnaire development and validation
- 2014
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 53:3, s. 368-377
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe present study reports on the development and first steps of validation of the Gastrointestinal Side Effects Questionnaire (GISEQ), a measure of patient-reported gastrointestinal symptoms following local radiotherapy to the prostate. The questionnaire design provides a novel approach of assessment of side effects of prostate radiotherapy, by enabling measurement of patient-perceived change in symptoms.Material and methodsThe eight-item GISEQ was administered to 130 prostate cancer patients referred to radiotherapy. Patients completed the GISEQ at four, eight and 15 weeks after start of radiotherapy. The psychometric properties including validity, reliability, responsiveness and feasibility were evaluated. The EORTC QLQ-C30 and QLQ-PR25 were chosen as comparative measures.ResultsExpert opinion supported content validity. For concurrent validity, correlation between the GISEQ and matching items in the EORTC questionnaires was moderate but significant (r > 0.41, p < 0.001). The responsiveness was adequate, indicated by changes in GISEQ scores over time corresponding to the effects of radiation. Internal consistency was satisfactory (overall Cronbach's α> 0.70). Sensitivity and specificity for items diarrhea, constipation and blood in stools ranged from 50% to 100% and from 68% to 100%, respectively. All items had a floor effect above 15%. The response rates ranged from 85% to 92% and missing items was < 0.8%, indicating good feasibility.ConclusionsThe GISEQ showed satisfactory internal consistency and adequate content validity, concurrent validity and responsiveness. It is brief, easy to use and can be quickly evaluated, making it useful not only for research but possibly also for clinical settings. Modification of response scale and extension of items are potential improvements. Further work is needed to strengthen the psychometric qualities of the GISEQ and to evaluate its clinical use and potential effects of response shift and recall bias.
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| 9. |
- Åsten, Pamela, et al.
(författare)
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Associations between speech features and phenotypic severity in Treacher Collins syndrome
- 2014
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Ingår i: BMC Medical Genetics. - : Springer Science and Business Media LLC. - 1471-2350. ; 15:47
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Background Treacher Collins syndrome (TCS, OMIM 154500) is a rare congenital disorder of craniofacial development. Characteristic hypoplastic malformations of the ears, zygomatic arch, mandible and pharynx have been described in detail. However, reports on the impact of these malformations on speech are few. Exploring speech features and investigating if speech function is related to phenotypic severity are essential for optimizing follow-up and treatment. Methods Articulation, nasal resonance, voice and intelligibility were examined in 19 individuals (5–74 years, median 34 years) divided into three groups comprising children 5–10 years (n = 4), adolescents 11–18 years (n = 4) and adults 29 years and older (n = 11). A speech composite score (0–6) was calculated to reflect the variability of speech deviations. TCS severity scores of phenotypic expression and total scores of Nordic Orofacial Test-Screening (NOT-S) measuring orofacial dysfunction were used in analyses of correlation with speech characteristics (speech composite scores). Results Children and adolescents presented with significantly higher speech composite scores (median 4, range 1–6) than adults (median 1, range 0–5). Nearly all children and adolescents (6/8) displayed speech deviations of articulation, nasal resonance and voice, while only three adults were identified with multiple speech aberrations. The variability of speech dysfunction in TCS was exhibited by individual combinations of speech deviations in 13/19 participants. The speech composite scores correlated with TCS severity scores and NOT-S total scores. Speech composite scores higher than 4 were associated with cleft palate. The percent of intelligible words in connected speech was significantly lower in children and adolescents (median 77%, range 31–99) than in adults (98%, range 93–100). Intelligibility of speech among the children was markedly inconsistent and clearly affecting the understandability. Conclusions Multiple speech deviations were identified in children, adolescents and a subgroup of adults with TCS. Only children displayed markedly reduced intelligibility. Speech was significantly correlated with phenotypic severity of TCS and orofacial dysfunction. Follow-up and treatment of speech should still be focused on young patients, but some adults with TCS seem to require continuing speech and language pathology services.
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