| 1. |
- Bengmark, S., et al.
(författare)
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NEUESTER STAND DER LEBERCHIRURGIE
- 1982
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Ingår i: Zentralblatt fur Chirurgie. - 0044-409X. ; 107:12, s. 689-696
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Carlsson, Jan, et al.
(författare)
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Catalase inhibition by sulfide and hydrogen peroxide-induced mutagenicity in Salmonella typhimurium strain TA102
- 1988
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Ingår i: Mutation research. - : Elsevier. - 0027-5107 .- 1873-135X. ; 202:1, s. 59-64
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Tidskriftsartikel (refereegranskat)abstract
- The lethal and mutagenic effects of hydrogen peroxide were studied in exponentially growing cultures of Salmonella typhimurium strain TA102. Exposure of the cultures to non-lethal levels of sodium sulfide significantly increased the lethality and mutagenicity of hydrogen peroxide. The catalase activity was decreased in cells exposed to sodium sulfide, but there were no changes in the cellular levels of superoxide dismutase, glutathione reductase, or NADPH-dependent alkyl hydroperoxide reductase. Hydrogen peroxide-induced mutagenesis and killing of S. typhimurium strain TA102 in the presence of sulfide may in part be explained by an inactivation of catalase by sulfide.
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| 3. |
- Hafstrom, L., et al.
(författare)
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Blood flow in experimental liver tumors : Effect of vasoactive drugs
- 1980
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Ingår i: Acta Chirurgica Scandinavica. - 0001-5482. ; 146:3, s. 149-153
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Tidskriftsartikel (refereegranskat)abstract
- The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepatic artery flow was unchanged. Histamine induced a decrease in hepatic and pulmonary blood flow. Vasopressin showed a pronounced decrease in blood flow in all organs measured. Relative tumor blood flow was registered as the ratio between tumor flow and arterial hepatic flow. A relative decrease of tumor blood flow in relation to surrounding liver tissue blood flow was registered after infusion of vasopressin. No effects were seen after glucagon or histamine infusion.
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| 4. |
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| 5. |
- Persson, Bengt L., et al.
(författare)
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ATP-driven transhydrogenase provides an example of delocalized chemiosmotic coupling in reconstituted vesicles and in submitochondrial particles
- 1987
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Ingår i: Biochimica et Biophysica Acta - Bioenergetics. - : Elsevier BV. - 0005-2728 .- 1879-2650. ; 894:2, s. 239-251
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Tidskriftsartikel (refereegranskat)abstract
- The mechanism of coupling between mitochondrial ATPase (EC 3.6.1.3) and nicotinamide nucleotide transhydrogenase (EC 1.6.1.1) was studied in reconstituted liposomes containing both purified enzymes and compared with their behavior in submitochondrial particles. In order to investigate the mode of coupling between the transhydrogenase and the ATPase by the double-inhibitor and inhibitor-uncoupler methods, suitable inhibitors of transhydrogenase and ATPase were selected. Phenylarsine oxide and A3′-O-(3-(N-(4-azido-2-nitrophenyl)amino)propionyl)-NAD+ were used as transhydrogenase inhibitors, whereas of the various ATPase inhibitors tested aurovertin was found to be the most convenient. The inhibition of the ATP-driven transhydrogenase activity was proportional to the inhibition of both the ATPase and the transhydrogenase. Inhibitor-uncoupler titrations showed an increased sensitivity of the coupled reaction towards carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) — an uncoupler that preferentially uncouples localized interactions, according to Herweijer et al. (Biochim. Biophys. Acta 849 (1986) 276–287) — when the primary pump was partially inhibited. However, when the secondary pump was partially inhibited the sensitivity towards FCCP remained unchanged. Similar results were obtained with submitochondrial particles. These results are in contrast to those obtained previously with the ATP-driven reverse electron flow. In addition, the amount of uncoupler required for uncoupling of the ATP-driven transhydrogenase was found to be similar to that required for the stimulation of the ATPase activity, both in reconstituted vesicles and in submitochondrial particles. Uncoupling of reversed electron flow to NAD+ required much less uncoupler. On the basis of these results, it is proposed that, in agreement with the chemiosmotic model, the interaction between ATPase and transhydrogenase in reconstituted vesicles as well as in submitochondrial particles occurs through the [...]. In contrast, the energy transfer between ATPase and NADH-ubiquinone oxidoreductase appears to occur via a more direct interaction, according to the above-mentioned results by Herweijer et al.
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| 6. |
- Persson, Bengt L., et al.
(författare)
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Energy-linked nicotinamide nucleotide transhydrogenase : Properties of proton-translocating mitochondrial transhydrogenase from beef heart purified by fast protein liquid chromatography
- 1984
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 259, s. 8626-8632
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondrial nicotinamide nucleotide transhydrogenasefrom beef heart was purified by a novel procedureinvolving fast protein liquid chromatography andcharacterized with respect to molecular and catalyticproperties. The method is reproducible, gives highlypure transhydrogenase as judged by silver staining,and can be modified to produce large amounts of puretranshydrogenase protein suitable for e.g. sequencingand other protein chemical studies.Transhydrogenase purified by fast protein liquidchromatography is reconstitutively active and pumpsprotons as indicated by an extensive quenching of 9-aminoacridine fluorescence. Under conditions whichgenerate a proton gradient in the absence of a membranepotential the activity of reconstituted transhydrogenaseis close to zero indicating a complete andproper incorporation in the membrane and a preferentialregulation of the enzyme by a proton gradientrather than a membrane potential.Treatment of reconstituted transhydrogenase withN,N-dicyclohexylcarbodiimide results in an inhibitionof proton pump activity without an effect on uncoupledcatalytic activity, suggestingt hat proton translocationand catalytic activities are not obligatory linked orthat this agent separates proton pumping from thecatalytic activity.
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| 7. |
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| 8. |
- Persson, L A, et al.
(författare)
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Infant feeding and dental caries--a longitudinal study of Swedish children.
- 1985
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Ingår i: Swedish Dental Journal. - 0347-9994. ; 9:5, s. 201-6
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the study was to compare dietary habits in children at the age of 12 months with the caries status at the age of 3. In 312 children, residing in 3 different parts of Sweden, a dietary study was carried out at 12 mo. of age, and in 275 (88%) a caries examination was performed at the age of 3. At 12 months of age, higher education of the mother was positively correlated with consumption of bread, vegetables, fruit and meat and negatively with frequency of sucrose-rich foods. At the age of 3, caries was diagnosed in 16% of the children. The prevalence of cavities was related to the level of education of the mother in all 3 areas, cavities being most numerous in children whose mother had received a shorter education. A discriminant analysis showed that the equation discriminating the two a priori defined groups, one with and one without caries at the age of 3, contained a number of sucrose-rich foods. The 3-year-old children with caries had generally consumed cakes, butter, bread and sweet soups more frequently at the age of 12 months than the children in the non-caries group. The analysis thus indicated that - on the group level at least - a dietary pattern, which may be casually linked with future dental caries development, was already established at the age of 12 months. Dietary counselling, when the child is 12-18 mo. of age and based upon information about the dietary habits of the child could thus be of value to prevent caries in the preschool child.
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