| 1. |
- Berggren, Kristina, 1971, et al.
(författare)
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3-Aminopiperidine Based Peptide Analogues as the First Selective Noncovalent Inhibitors of the Bacterial Cysteine Protease IdeS
- 2012
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 55:6, s. 2549-2560
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Tidskriftsartikel (refereegranskat)abstract
- A series of eight peptides corresponding to the amino acid sequence of the hinge region of IgG and 17 newly synthesized peptide analogues containing a piperidine moiety as a replacement of a glycine residue were tested as potential inhibitors of the bacterial IgG degrading enzyme of Streptococcus pyogenes, IdeS. None of the peptides showed any inhibitory activity of IdeS, but several piperidine-based analogues were identified as inhibitors. Two different analysis methods were used: an SDS-PAGE based assay to detect IgG cleavage products and a surface plasmon resonance spectroscopy based assay to quantify the degree of inhibition. To investigate the selectivity of the inhibitors for IdeS, all compounds were screened against two other related cysteine proteases (SpeB and papain). The selectivity results show that larger analogues that are active inhibitors of IdeS are even more potent as inhibitors of papain, whereas smaller analogues that are active inhibitors of IdeS inhibit neither SpeB nor papain. Two compounds were identified that exhibit high selectivity against IdeS and will be used for further studies.
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| 2. |
- Blennow, Kristina, et al.
(författare)
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Societal Impacts of Storm Damage
- 2013
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Ingår i: Living with Storm Damage to Forests. - : European Forest Institute. - 9789525980080 - 9789525980097 ; 3, s. 70-77
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Bokkapitel (refereegranskat)abstract
- Wind damage to forests can be divided into (1) the direct damage done to the forest and (2) indirect effects. Indirect effects may be of different kinds and may affect the environ- ment as well as society. For example, falling trees can lead to power and telecommunica- tion failures or blocking of roads. The salvage harvest of fallen trees is another example and one that involves extremely dangerous work. In this overview we provide examples of different entities, services, and activities that may be affected by wind damage to for- ests. We illustrate how valuation of the damage depends on the perspective applied and how the affected entities, services, and activities may represent different types of values. Finally we suggest means for how to actively manage the risk in an ethically sustaina- ble way. Many of our examples will be drawn from the experiences of the wind damage Gudrun in southern Sweden on 8–9 January 2005. The direct as well as indirect effects, which are described, are by no means unique to the Gudrun wind damage event and similar or even worse effects have been described after the wind damage events Martin and Lothar in 1999, and Klaus in 2009.
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| 3. |
- Blennow, Kristina, et al.
(författare)
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Understanding risk in forest ecosystem services: implications for effective risk management, communication and planning
- 2014
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Ingår i: Forestry. - : Oxford University Press (OUP). - 0015-752X .- 1464-3626. ; 87, s. 219-228
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Tidskriftsartikel (refereegranskat)abstract
- Uncertainty, insufficient information or information of poor quality, limited cognitive capacity and time, along with value conflicts and ethical considerations, are all aspects that make risk management and risk communication difficult. This paper provides a review of different risk concepts and describes how these influence risk management, communication and planning in relation to forest ecosystem services. Based on the review and results of empirical studies, we suggest that personal assessment of risk is decisive in the management of forest ecosystem services. The results are used together with a review of different principles of the distribution of risk to propose an approach to risk communication that is effective as well as ethically sound. Knowledge of heuristics and mutual information on both beliefs and desires are important in the proposed risk communication approach. Such knowledge provides an opportunity for relevant information exchange, so that gaps in personal knowledge maps can be filled in and effective risk communication can be promoted.
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| 4. |
- Hörnsten, Åsa, et al.
(författare)
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Strategies in health-promoting dialogues: primary healthcare nurses' perspectives : a qualitative study
- 2014
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Ingår i: Scandinavian Journal of Caring Sciences. - : John Wiley & Sons. - 0283-9318 .- 1471-6712. ; 28:2, s. 235-244
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Tidskriftsartikel (refereegranskat)abstract
- Aim and objectives The aim of this study was to describe dialogic strategies about health and lifestyle used by primary healthcare nurses (PHNs) in the Vasterbotten Intervention Programme (VIP) in Sweden.Background The VIP offers all citizens aged 40, 50 and 60 in Vasterbotten County an individual health check-up followed by a health-promoting dialogue with a specialist PHN. Inconsistencies in previous reports of the effects of lifestyle counselling and health promotion suggest that it is important to study dialogues about health and lifestyle to understand health-promoting strategies and to highlight aspects important to improving their effects.Method In 2010, we conducted in-depth interviews with ten experienced PHNs working with the VIP at eight healthcare centres in Vasterbotten County, Sweden. Qualitative content analysis was used to illuminate the nurses' strategies in health-promoting dialogues. The Regional Ethics Board (Dno 06-126M) approved the study.Results The PHNs used various strategies in dialogues about health and lifestyle that fell under the five themes 'Guiding patients vs. pressuring them; Adjusting to patients vs. directing the conversation; Inspiring confidence vs. instilling fear; Motivating and supporting patients vs. demanding responsibility; and lastly, Introducing emotionally charged subjects or avoiding them'.Conclusions The results of this study may add knowledge about the difficulties and opportunities in health counselling. In the discussion, we suggest professional reflection as a means to increase knowledge and awareness about the self and context in the process of health counselling.
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| 5. |
- Persson, Eva-Kristina, et al.
(författare)
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Fathers' sense of security during the first postnatal week-A qualitative interview study in Sweden
- 2012
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Ingår i: Midwifery. - : Elsevier BV. - 0266-6138 .- 1532-3099. ; 28:5, s. e697-e704
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Tidskriftsartikel (refereegranskat)abstract
- Background father's sense of security in the early postnatal period is important for the whole family. An instrument, which measures Parents' Postnatal Sense of Security (the PPSS instrument), is under development.Objective to explore and describe factors, which influence fathers' sense of security during the first postnatal week.Methods an explorative design with a qualitative approach was used. Thirteen fathers from three hospital uptake areas in Southern Sweden were interviewed using focus group discussions and individual interviews. Analysis was carried out using qualitative content analysis.Findings participation in the processes of pregnancy birth and early parenthood emerged as the main category for fathers' postnatal sense of security. The emergent categories were; ‘willingness to participate and take responsibility’, ‘being given the opportunity to take responsibility’, ‘being assured about mother's and baby's well-being’, ‘having someone to turn to—knowing who to ask’, ‘being met as an individual’ and ‘being met by competent and supporting staff’.Key conclusions and implications for practice new and specific items of importance when investigating fathers' sense of security during the early postnatal period have been pinpointed. Fathers' sense of early postnatal security may be enhanced by giving them a genuine opportunity to participate in the whole process and by giving them the opportunity to stay overnight at the hospital after the birth. Midwives and care organisations need to give clear information about where competent help and advice can be obtained at all hours. Midwives should strengthen the fathering role by acknowledging and listening to the father as an individual person.
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| 6. |
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| 7. |
- Voog, Hanna, et al.
(författare)
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Tillgänglighet, närhet och synlighet – gemensamma utmaningar för LUB-nätverket för att möta forskares behov av stöd vid Lunds universitet
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report presents a project at Lund University Libraries (LUB) during the fall of 2012, with the object to identify areas where the present research support services ought to be developed and strengthened. The project is three folded and contains a) a literature review focusing on definitions and examples of research support services as well as researchers’ needs and experiences of support services, b) a survey to get an overview of the support services offered today at LUB, the decentralized library network at Lund University, and c) focus group interviews with researchers, one group from each partaking faculty, to investigate key obstacles in their research processes. In all three parts a model of the research process schematically divided into four phases was applied; to start a project, to collect material, to process/analyze/write and to communicate the results. The first two stages of the project, the literature overview and the survey, form a background and both show that many support services are concentrated around the phases to collect material and to communicate results. The findings from the focus group interviews point to common needs and issues as well as special needs and issues related to different ways of doing and communicating research. Common for most researchers is limited time, a need for funding and an everyday fragmentation. They talk about the importance of networks, their efforts to navigate in an abundance of material and ways to find it and a need for overviews and help to understand new ways and demands to communicate. Most concern is expressed in the phases to start a project, to collect material and to communicate results. A major conclusion is that the research support services need to be available, visible and in close proximity to the researchers. Further, the development of support services needs to take into consideration both common traits as well as local variations in research practices. Therefore, discussions concerning LUB as a whole, need to be related to discussions at the single faculty libraries. Apart from knowledge about how to address the research support services at LUB, the project generates a model for how librarians can understand the research community that they are working with and with whom to create networks and partnerships for the future.
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| 8. |
- Abramovich, Shoshana, et al.
(författare)
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Some new refined Hardy type inequalities with general kernels and measures
- 2010
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Ingår i: Aequationes Mathematicae. - : Springer Science and Business Media LLC. - 0001-9054 .- 1420-8903. ; 79:1-2, s. 157-172
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Tidskriftsartikel (refereegranskat)abstract
- We state and prove some new refined Hardy type inequalities using the notation of superquadratic and subquadratic functions with an integral operator Ak defined by, where k: Ω1 × Ω2 is a general nonnegative kernel, (Ω1, μ1) and (Ω2, μ2) are measure spaces and,. The relations to other results of this type are discussed and, in particular, some new integral identities of independent interest are obtained.
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| 9. |
- Adelöf, Anna, et al.
(författare)
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Förvaltning av SNOMED CT som en del i det nationella fackspråket för vård och omsorg
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- Förvaltningsrapporten fokuserar på Snomed CT, eftersom det redan i dag finns rutiner för förvaltningar av termbanken och nationella hälsorelaterade klassifikationer. Ett särskilt utvecklingsarbete kommer att krävas för dessa delar.Rapporten tar upp syfte och mål med förvaltningen. Utöver det redogör rapporten för vilka konkreta ansvarsområden som ingår i förvaltningen av Snomed CT. Målet för förvaltningen är att Socialstyrelsen regelbundet ska kunna tillhandahålla en kontrollerad och uppdaterad release av Snomed CT. Det skulle möjliggöra användning inom vård och omsorg. Rapporten tar även upp behovet av kompetens, utbildning och finansiella resurser.
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| 10. |
- Barlow, Lotti, et al.
(författare)
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Nationellt fackspråk för vård och omsorg : Slutrapport
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- SammanfattningEtt tillgängligt och använt nationellt fackspråk ska bidra till en god och säker vård och omsorg. Det ska även medverka till att kvaliteten och resultaten på området ska kunna följas upp och jämföras på ett mer effektivt sätt. Slutrapporten presenterar resultatet av projektet Nationellt fackspråk för vård och omsorg samt förslag till förvaltning och utveckling.ResultatetResultatet innefattar bland annat att det internationella begreppssystemet Snomed CT är översatt till svenska och att det är förberett för förvaltning och distribution. Socialstyrelsen har även tagit fram och testat metoder för förvaltning och utveckling av det nationella fackspråket i sin helhet. Därtill har representanter för målgrupperna informerats och fått kunskap.Rapporten innehåller en utförlig beskrivning av det nationella fackspråkets sammantagna innehåll: Socialstyrelsens termbank, klassifikationer och kodverk, den svenska versionen av Snomed CT, metoder för utveckling och förvaltning samt regler för användning.Förvaltning, införande och resursbehovI rapporten finns förslag till hur hela det nationella fackspråket kan tas omhand av Socialstyrelsen och hur det kan införas i vården och omsorgen. Projektets övergång till en långsiktigt hållbar organisation kräver resurser. Därför redogör rapporten för det förväntade resursbehovet för förvaltning och utveckling. Bland annat föreslås en treårig utbildningsinsats samt stimulansbidrag för införande.Krav på styrning, samordning och förtydligat ansvarRapporten betonar behovet av en samlad och medveten styrning av utvecklingen inom området. Socialstyrelsen vill ha en samordnande roll i utvecklingen och förvaltningen av det nationella fackspråket. Myndigheten föreslås få det initiala ansvaret för att utbilda användare och att driva frågor om det nationella fackspråket.Vidare vill Socialstyrelsen få ett uttalat mandat att samordna de nationella aktiviteter som drivs med koppling till Snomed CT. Rapporten pekar ut några särskilt prioriterade områden som myndigheten borde få i uppdrag att arbeta vidare inom.Kunskapsstyrning och normgivningEn viktig slutsats i rapporten är att användningen av det nationella fackspråket behöver regleras för att målet om ökad säkerhet för klienter och patienter ska kunna uppnås. I dagsläget bedöms föreskrifter vara den metod som bäst kan garantera ett brett genomförande.Målgrupper för slutrapportenSlutrapporten riktar sig till beslutsfattare i kommuner och landsting, vård- och omsorgspersonal med särskilt intresse eller ansvar för dokumentationsfrågor och professionella organisationer. Den riktar sig också till terminologiansvariga i kommuner och landsting, IT-direktörer, IT-leverantörer samt aktörer inom den nationella strategin för eHälsa.
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