| 1. |
- Asp, Michaela, et al.
(författare)
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Spatial detection of fetal marker genes expressed at low level in adult human heart tissue
- 2017
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Heart failure is a major health problem linked to poor quality of life and high mortality rates. Hence, novel biomarkers, such as fetal marker genes with low expression levels, could potentially differentiate disease states in order to improve therapy. In many studies on heart failure, cardiac biopsies have been analyzed as uniform pieces of tissue with bulk techniques, but this homogenization approach can mask medically relevant phenotypes occurring only in isolated parts of the tissue. This study examines such spatial variations within and between regions of cardiac biopsies. In contrast to standard RNA sequencing, this approach provides a spatially resolved transcriptome- and tissue-wide perspective of the adult human heart, and enables detection of fetal marker genes expressed by minor subpopulations of cells within the tissue. Analysis of patients with heart failure, with preserved ejection fraction, demonstrated spatially divergent expression of fetal genes in cardiac biopsies.
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| 2. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Persson, Erik, et al.
(författare)
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Det gröna kulturarvet : introduktion
- 2018
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Ingår i: Det Gröna Kulturarvet. - 9789157689535 ; , s. 4-8
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Persson, Erik, et al.
(författare)
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The Green Heritage
- 2018
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Ingår i: Det Gröna Kulturarvet. - 9789157689535 ; , s. 9-13
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Persson, Patrik, et al.
(författare)
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Adenosine A(2)a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress
- 2015
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Ingår i: Acta Physiologica. - : Wiley: 12 months. - 1748-1708 .- 1748-1716. ; 214:3, s. 311-318
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Tidskriftsartikel (refereegranskat)abstract
- AimDiabetic patients are at increased risk for kidney disease. There is presently no clinical treatment available that effectively protects kidney function in diabetics. This study investigates whether chronic stimulation of the adenosine A(2a) receptor (A(2a)AR) protects kidney function in insulinopenic diabetic rats. MethodsStreptozotocin-induced diabetic rats and corresponding controls were chronically treated with the adenosine A(2a)AR agonist CGS21680 throughout the four-week diabetes duration. Kidney function was thereafter investigated, and urine and plasma samples were collected for analysis of protein, oxidative stress and inflammatory markers. ResultsGlomerular filtration rate, renal blood flow, filtration fraction and diabetes-induced kidney hypoxia were all unaffected by chronic A(2a)AR stimulation. Furthermore, diabetic rats had increased oxidative stress, which was further increased by chronic A(2a)AR stimulation. However, the 10-fold increased urinary protein excretion observed in the diabetic rats was completely prevented by chronic A(2a)AR stimulation. These beneficial effects were accompanied by reduced levels of the pro-inflammatory TNF- and increased levels of the anti-inflammatory IL-10 as well as decreased infiltration of macrophages, glomerular damage and basement membrane thickness. ConclusionChronic A(2a)AR stimulation prevents proteinuria and glomerular damage in experimental diabetes via an anti-inflammatory mechanism independent of oxidative stress and kidney hypoxia.
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| 6. |
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| 7. |
- Ericsson, Daniel, 1967-, et al.
(författare)
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Entrepreneurship lost and found
- 2017
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Ingår i: Proceedings of the 5th International Conference IMES, 25–26 May, 2017, Prague, University of Economics. - Prague : University of Economics, Prague, Oeconomica Publishing House. - 9788024522166 ; , s. 190-199
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Konferensbidrag (refereegranskat)abstract
- Purpose: In light of the many attempts within the social/societal turn of entrepreneurship to disconnect entrepreneurship from economic rationality and embrace it as an act of social becoming, the purpose is to reconnect entrepreneurship to its primary function within the capitalist regime: to make money and accumulate capital. This function, it is argued, is lost in present day research on entrepreneurship, and the aim therefore is to present a framework in which both economic and social aspects are found crucial for understanding entrepreneurship.Design/methodology/approach: Following post-positivist research traditions the research is based on an autoethnographic case study of entrepreneurship in the field of music. In focus is the phenomenon of collecting records, and the cultural web of social and economic significances that unfolds by means of the authors confessional tales about engaging in record collecting is used as an interpretative lever to question the dichotomy between social and economic rationality and value within contemporary research on entrepreneurship. Findings: In contrast to becoming or being perspectives on entrepreneurship, our interpretations lead us to frame entrepreneurship in terms of a having-mode. This mode in turn suggests a primary epistemic orientation based upon three interrelated socio-economic aspects: 1) a systemic know-what in order to distinguish field-specific values from non-value, 2) a systemic know-how to convert social value into economic value, and vice versa; and 3) a systemic know-how to create, capitalise upon and accrue field specific surplus value. Research/practical implications: The proposed framework breaks with both modern and postmodern notions of entrepreneurship, and thereby opens up new vistas for research on entrepreneurship as intrinsically a social and economic phenomenon.Originality/value: By opening up new vistas for research on entrepreneurship, alternative ways of describing, prescribing and understanding entrepreneurship are offered.
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| 8. |
- Ericsson, Daniel, 1967-, et al.
(författare)
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Samlandets kunskapsekonomi
- 2015
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Ingår i: Presented at Konferensen Musik och Samhälle VII, Lund University, October 8-9, 2015.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Ericsson, Daniel, 1967-, et al.
(författare)
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Samlandets kunskapsekonomi
- 2016
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Ingår i: M&STE: elektronisk tidskrift för konferensen Musik & samhälle. - Lund. - 2002-4622. ; 1:1, s. 37-51
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- I den här texten problematiseras hur samlare av musik blir till och vilken betydelse kunskap om musik har för samlarens tillblivelse. Av särskilt intresse är att utveckla förståelse för det som sällan berörs när musiksamlande kommer på tal, nämligen samlandets ekonomiska aspekter.
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| 10. |
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