| 1. |
- Gustavsson, Carl G, et al.
(författare)
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Vein blood rheology alterations immediately after coronary angiography with iohexol, and one month later.
- 1996
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Ingår i: Clinical Hemorheology. - New York, USA : Pergamon Press. - 0271-5198. ; 16:6, s. 737-743
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Tidskriftsartikel (refereegranskat)abstract
- Abstract The effects of coronary angiography with iohexol upon vein blood rheology were studied before, immediately after and one month after angiography. Haematocrit decreased from 40.5 % to 39.0 % immediately after angiography (p < 0.01). When this was compensated for by in vitro standardisation of sample haematocrits to 45% there was a blood viscosity increase by 10.9 - 15.0 %, at the four studied shear rates 0.8 s-1, 2.3 s-1, 19.6 s-1, and 40.0 s-1 (p < 0.05 - p < 0.01). In unadjusted samples, i.e. at the patients natural haematocrits, there was only a slight and statistically non-significant blood viscosity increase. Plasma viscosity decreased immediately after angiography, and was even lower 1 month after angiography. The haematocrit reduction correlated significantly with the iohexol doses (correlation coefficient -0.852, p < 0.001), whereas no significant correlation was found between the contrast volumes and the alterations of blood and plasma viscosity. Except for plasma viscosity, there were no significant differences when the values before angiography and one month later were compared. Key words: Blood viscosity; Contrast media; Iohexol; Coronary angiography; Haematocrit; Haemorheology
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| 2. |
- Cwikiel, Magdalena, et al.
(författare)
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Changes of blood viscosity in pateints treated with 5-fluorouracil : A link to cardiotoxicity?
- 1995
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Ingår i: Acta Oncologica. - Norway. - 0284-186X .- 1651-226X. ; 34:1, s. 83-85
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU. The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.
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| 3. |
- Larsson, Hans, et al.
(författare)
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Studies on blood pressure, pulse rate, laboratory parameters, blood and plams viscosity in 55 patients with impaired glucose tolerance (borderline diabetes)
- 1999
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Ingår i: Biorheology. - Amsterdam,The Netherlands : IOS Press. - 0006-355X .- 1878-5034. ; 36:1/2, s. 87-88
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Tidskriftsartikel (refereegranskat)abstract
- Abstract As a substudy to a broader investigation concerning clinical parameters in patients with impaired glucose tolerance blood and plasma viscosity were studied in 55 patients in ages from 39 to 81 years (mean age 62,4 years). These patients were selected from a large health study in southern Sweden where they presented with impaired glucose tolerance but without signs of vascular disease. At the time of our study these 55 patients were still not, 20 years after their first oral glucose tolerance test, classified as ouvert diabetes. Our intention was to study effects of minor disturbances of glucose tolerance on blood rheology. The patients had a laboratory profile close to that of patients with ouvert type 2 diabetes. Compared to a ontrol group of healthy individuals they had higher values for blood and plasma viscosity at all shear rates (p<0.001), higher values for b-glucose, ESR, triglycerides, s-GT (p<0.05-0.005) and lower values for s-creatinine p<0.001). It was also found that diastolic pressure, both at rest and after exercise, was positively correlated to plasma viscosity. This holds true also for systolic arm pressure. Pulse rate at rest and after exercise showed a negative correlation to blood rheology parameters. The pool of data is very large and further analyses are under way. So far our data show that even minor abnormalities of glucose metabolism are harmful and create a risk for vascular disease.
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| 4. |
- Persson, Kristina Bränd, et al.
(författare)
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Välkommet bidrag till diskussionen.
- 1999
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Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 76:2, s. 201-203
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Persson, Sylvi Ulrika, et al.
(författare)
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Correlations between fatty acid composition of the erythrocyte membrane and blood rheology data
- 1996
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513 .- 1502-7686. ; 56, s. 183-190
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Tidskriftsartikel (refereegranskat)abstract
- Abstract The fatty acid composition of erythrocyte membrane phospholipids (phosphatidyl choline, PC, and phosphatidyl ethanolamine, PE) and erythrocyte filterability was studied in seven subjects with type I1 diabetics before and after change of therapy from oral hypoglycaemic agents to insulin. For comparison the same variables were also studied in 10 healthy controls. In the diabetic group the greatest changes in fatty acid composition were found before treatment in the PE fraction, corresponding to the inner part of the red cell membrane. We found increased values for 16 : 0 (p<0.001), 18 : 1 (p<0.01) and 20 :4 (ω-6) (p<0.05) and decreased values for 16 : 1 (p <0.01) and 18 : 3 (ω-6) (p <0.001), compared to values for the healthy controls. The proportion of fatty acids in the inner leaflet of the membrane did not correlate to the red cell filterability in diabetics or healthy subjects. In the PC fraction, which corresponds to the outer leaflet of the erythrocyte membrane, we found higher values for 16 : 0 (NS), 18 : 1 (p <0.05), 20 : 4 (ω-6) (NS) and 22 : 5 (ω-3) (p <0.01), and lower values for 16 : 1 (p < 0.05) in diabetics, compared to healthy controls. In the PC fraction an increased proportion of 16 : 0 was inversely correlated with red cell transit time (RCTT) (p <0.05), and increased proportions of 16: 1 and 18 : 0 were correlated with a high RCTT (p <0.05). Insulin treatment did not significantly change red cell deformability or the fatty acid composition of the red cell membrane. Our results also indicate that palmitic acid (16 : 0) may be favourable in the PC fraction and stearic acid (18 : 0) unfavourable with respect to the rheological properties of erythrocytes. Key words: Diabetes; Erythrocyte deformability; Erythrocyte phospholipids; Hemorheology; Lipoprotein; Saturated fatty acids; Unsaturated fatty acids.
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| 6. |
- Persson, Sylvi Ulrika, et al.
(författare)
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How should blood rheology be measured in macroglobulinaemia?
- 1998
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - Norway. - 0036-5513 .- 1502-7686. ; 58, s. 669-676
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Blood and plasma viscosity were measured in 13 patients with monoclonal macroglobulinaemia. Blood viscosity was measured at natural hematocrit and after adjustment to 45%. Studies were performed at three different temperatures, +24oC, +32oC and +37oC. Plasma viscosity was measured in a rotational viscometer and in a capillary tube at the above-mentioned temperatures. Blood viscosity was to some extent related to the patients' symptoms, whereas a correlation between blood and plasma viscosity became less pronounced with decreasing shear rates, indicating that plasma viscosity is not a perfect indicator of blood viscosity in macroglobulinaemia. It was shown that red cell concentration, besides the concentration of monoclonal immunoglobulins (= paraproteins (PP)), is an important determinant of blood viscosity. The correlation between red cell concentration and viscosity became stronger with decreasing shear rate. Whole blood viscosity at low shear rates seems to be the best indicator of rheological symptoms in patients with macroglobulinaemia. It is concluded that blood rheology in patients with macroglobulinaernia is best studied at + 32°C to + 37°C in whole blood and at low shear rates. Key words: Blood viscosity; Hematocrit: Hyperviscosity syndrome; Hypervolemia; IgM; Immunoglobulins; Monoclonal; Plasma viscosity; Waldenström´s disease.
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| 7. |
- Persson, Sylvi Ulrika, et al.
(författare)
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Reduced number of cirkulating monocytes after institution of insulin therapy : Relevance for development of atherosclerosis in diabetics?
- 1998
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Ingår i: Angiology. - New York, USA : Westminster Publications Inc.. - 0003-3197 .- 1940-1574. ; 49:6, s. 423-433
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Twelve patients with Type I1 diabetes mellitus, insufficiently controlled with oral hypoglycaemic agents, were studied before, after 2 months, and after 4 months on insulin therapy. For comparison the same variables were also studied in 10 healthy subjects. From the start, in the diabetic group, the authors found alterations in the hemorheologic parameters indicated by increased values for whole blood viscosity, plasma viscosity, red cell transit time (RCTT), and decreased values for white cell initial relative filtration rate (IrFR). In hematologic parameters they found increased values for mean corpuscular volume (MCV), leukocyte count, counts of neutrophils and rnonocytes, and a decreased count of lymphocytes. They also found increased values in the lipid parameters P-triglycerides and Apo B/Apo A-I ratio, risk factors of coronary atherosclerosis. After 4 months of insu!in treatment whole blood and plasma viscosity were still increased. but there was a partial improvement of lipoprotein abnormalities. Red and white cell filterability, however, tended to normalize. These results indicate that changes in blood cell filterability do not necessarily influence in vitro measurements of blood viscosity. The change in RCTT during the insulin treatment was associated with a decreased MCV and the change in white cell IrFR with a decrease in the number of monocytes. This change of white cell filterability during insulin therapy, probably due to a reduced number of monocytes, may be of interest in the study of atherosclerosis and circulatory disease in diabetics.
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| 8. |
- Persson, Ulrika
(författare)
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A conceptual and empirical examination of the management concept Supply chain management
- 1997
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The management concept "supply chain management" was introduced in early 1980s and since then the concept has recieved increasing attention within the fields of logistics. Supply chain management is viewed by many as a highly novel management concept, but comparison with earlier work reveals similarities. The main objective of this study is to examine the concept of supply chain management in order to seek the essence of the concept. A subordinated objective is to give some indication of the degree of novelty of supply chain management. Supply chain management is viewed in this study as a management concept or management theory and a method of five different examinations based on literature studies is developed. Firstly, the "reference network", the references within the examined literature, is established and examined. Secondly, the stated objectives and the stated fundamental beliefs are examined and thirdly, the stated definitions and stated theory relations are examined. These three examinations lay the foundation for the fourth, where the extent to which the different views of supply chain management in the examined literature share a common set of ideas and beliefs is examined. Finally, the extent to which the fundamental beliefs of supply chain management can be distinguished from the ideas and beliefs of its forerunners within logistics is examined. The examination reveal that it is possible to relate the stated objectives of supply chain management to each other in a "hierarchical weave" and that it is also possible to view the concept as constituted by a set of primitive fundamental beliefs. Tentatively, the following set is identified as the primitive fundamental beliefs of supply chain management, coordination and integration along the material flow, win-win relationships and end customer focus. Further, the examinations reveal that few stated definitions exist and that there are only vaguely stated theory relations. The most common stated theory relation is Poster's value chain. Based upon the examinations the conclusion is that supply chain management is a homogenous management concept, where its interpreters share common ideas and beliefs. However, the comparison with the forerunners shows that the ideas and beliefs of supply chain management also can be found in prior works. Accordingly, the degree of novelty is not judged as very high. Although most of the ideas of supply chain management may be found in the work by its forerunners it is concluded that their ideas are more fragmented and less apparent than the ideas of supply chain management.
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