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- Johansson, Jan, et al.
(författare)
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En bloc vs transhiatal esophagectorny for stage T3 N1 adenocarcinorna of the distal esophagus
- 2004
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Ingår i: Archives of Surgery. - 0004-0010. ; 139:6, s. 627-631
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Tidskriftsartikel (refereegranskat)abstract
- Hypothesis: En bloc esophagectomy (EBE) provides improved survival over transhiatal esophagectomy (THE) in patients with similarly sized transmural tumors (T3) and lymph node metastases (N1). Design: A retrospective case-control study of 2 methods of esophageal resection for cancer. Setting: University hospital (tertiary referral center for esophageal disease). Patients: There were 49 patients (27 who underwent EBE and 22 who underwent THE) With similar T3 N1 disease and the following matched criteria: tumors of similar size and location, more than 20 lymph nodes in the surgical specimen, R0 resection, no previous chemotherapy or radiation therapy, and follow-up until death or for a minimum of 5 years. Main Outcome Measure: Survival adjusted for differences in demographic and patient characteristics. Results: The number of nodes harvested was greatest after EBE vs THE (median, 52 vs 29 [range, 21-85 vs 20-60]; P<.001). The median number of involved nodes was similar after EBE vs THE (median, 5 vs 7 [range, 1-19 vs 1-16]). The only 2 independent factors that affected survival. in a Cox analysis were the number of involved lymph nodes (P=.01) and the type of resection (P=.03). Patients who underwent EBE had a survival benefit over those who underwent THE (P=.01). The survival benefit of EBE was seen only in patients with fewer than 9 involved lymph nodes (P<.001). Conclusion: En bloc esophagectomy confers a better survival than THE in patients with T3 N1 disease and fewer than 9 lymph node metastases.
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| 3. |
- Mähl, Stefan, 1972-
(författare)
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Studien zum mittelniederdeutschen Adverb
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present work is a corpus-based study of Middle Low German adverbs. The corpus covers the period from c. 1225 to c. 1600 and comprises several text categories (e.g. legal documents and literary texts) from the three main Middle Low German regions, Westphalia, Eastphalia and northern Lower Saxony. The extralinguistic parameters investigated are time, region, and text category. In addition, some semantic factors are taken into account, such as the type of adjective to which the derivational suffixes are added. The distinction between adjectives and adverbs and the concept of the suffix are discussed in some detail.The presentation of results is divided into three main parts. The first part investigates variation in the distribution of adverbial derivational suffixes such as -inge(s), -like(n) and -linge(n). The second part analyses variation in the distribution of a number of temporal adverbs, e.g. heute, immer/stets, jetzt/nun, nie, niemals and oft. In the third part, some syntactic aspects of Middle Low German adverbs are considered. In this context, the development of adverbs derived from adjectives in North Sea Germanic languages and in High German is compared.The present study shows that the distribution of both adverbial derivational suffixes and temporal adverbs exhibits variation across time and region. In contrast, the parameter of text category is shown to be of lesser importance.
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