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- Holst, J., et al.
(författare)
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Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis : A comparison with low molecular weight heparin
- 1994
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 71:2, s. 214-219
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to investigate whether a truncated recombinant Tissue Factor Pathway Inhibitor (TFPI1-161) which lacked the third Kunitz-type domain and the basic c-terminal region, had an antithrombotic effect comparable to LMWH in a randomised double-dummy study. The experimental thrombosis was induced in jugular veins, in a total of 40 rabbits by a combination of destruction of the endothelium and restricted blood flow. Group 1: placebo, gr 2- LMWH 60 anti-FXa IU/kg, gr 3-5: 0.1, 1.0 and 10.0 mg/kg TFPI1-161. TFPI1-161 reduced the thrombus weights in all treated groups, significantly in doses of 1.0 and 10.0 mg/kg compared to placebo. The frequency of thrombosis and occlusive thrombosis were also significantly reduced in those doses. The antithrombotic properties of TFPI1-161 (1.0-10.0 mg/ kg) measured as thrombus weight, frequency of thrombosis and frequency of occlusive thrombosis was equivalent to the antithrombotic properties of LMWH. In the anti-FXa, APTT and PT-assays TFPI1-161 displayed a dose dependent increase of activity. Recombinant-TFPI1-161 did not influence the anti-FIIa-assay. No haemorrhagic side effects were noted.
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| 2. |
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| 3. |
- Torell, Lena M., et al.
(författare)
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The importance of ion-polymer crosslinks in polymer electrolytes
- 1992
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Ingår i: Solid State Ionics. - Amsterdam : Elsevier. - 0167-2738 .- 1872-7689. ; 53-56:Part 2, s. 1037-1043
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Tidskriftsartikel (refereegranskat)abstract
- Raman-, Brillouin-and photon correlation spectroscopy have been used to study LiCF3SO3 and NaCF3SO3 containing polyethers (PEO and PPO). At focus are factors controlling the ion-polymer interactions, the formation of transient ionic crosslinks and their effect on the local flexibility. Brillouin and photon correlation spectroscopy show that the structural relaxation time is independent of the polymeric chain length for chains longer than n≈20 repeat units. For shorter chains OH bridging slightly stiffens the dynamics whereas for CH3 end-capped chains the local chain flexibility increases dramatically as n decreases. The crossover at ∼20 monomer indicates the number of monomers involved in the cooperative segmental rearrangements needed for structural relaxations in high Mw complexes, and thus also for an ionic displacement to occur in these systems. It is found that transient crosslinks are established for n > 4 and they considerably slow down the local dynamics. The density of crosslinks is found to be strongly temperature dependent and this is the reason for departure from Tg scaled dynamics in the complexes.
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