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Can alcohol control...
Can alcohol control policies reduce cirrhosis mortality? An interrupted time-series analysis in Lithuania
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Tran, Alexander (författare)
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Jiang, Huan (författare)
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Lange, Shannon (författare)
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Manthey, Jakob (författare)
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Štelemėkas, Mindaugas (författare)
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Badaras, Robertas (författare)
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Petkevičienė, Janina (författare)
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Radišauskas, Ričardas (författare)
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- Room, Robin, 1939- (författare)
- Stockholms universitet,Centrum för socialvetenskaplig alkohol- och drogforskning (SoRAD),La Trobe University, Australia
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Rehm, Jürgen (författare)
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(creator_code:org_t)
- 2022-01-30
- 2022
- Engelska.
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Ingår i: Liver international (Print). - : Wiley. - 1478-3223 .- 1478-3231. ; 42:4, s. 765-774
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background and Aims: The relationship between alcohol consumption and cirrhosis is well established. Policies that can influence population-level use of alcohol should, in turn, impact cirrhosis. We examined the effect of population-level alcohol control policies on cirrhosis mortality rates in Lithuania - a high-income European Union country with high levels of alcohol consumption.Methods: Age-standardized, monthly liver mortality data (deaths per 100,000 adults, aged 15+) from Lithuania were analysed from 2001 to 2018 (n = 216 months) while controlling for economic confounders (gross domestic product and inflation). An interrupted time-series analysis was conducted to estimate the effect of three alcohol control policies implemented in 2008, 2017 and 2018 and the number of cirrhosis deaths averted.Results: There was a significant effect of the 2008 (P < .0001) and 2017 (P = .0003) alcohol control policies but a null effect of the 2018 policy (P = .40). Following the 2008 policy, the cirrhosis mortality rate dropped from 4.93 to 3.41 (95% CI: 3.02-3.80) deaths per 100,000 adults, which equated to 493 deaths averted. Further, we found that following the 2017 policy, the mortality rate dropped from 2.85 to 2.01 (95% CI: 1.50-2.52) deaths per 100,000 adults, corresponding to 245 deaths averted.Conclusions: Our findings support the hypothesis that alcohol control policies can have a significant, immediate effect on cirrhosis mortality. These policy measures are cost-effective and aid in reducing the burden of liver disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- alcohol policy
- alcohol-related liver disease
- interrupted time-series analysis
- population-level interventions
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Tran, Alexander
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Jiang, Huan
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Lange, Shannon
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Manthey, Jakob
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Štelemėkas, Mind ...
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Badaras, Roberta ...
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visa fler...
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Petkevičienė, Ja ...
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Radišauskas, Rič ...
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Room, Robin, 193 ...
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Rehm, Jürgen
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Stockholms universitet