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| 2. |
- Berntorp, Erik, et al.
(författare)
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Consensus perspectives on prophylactic therapy for haemophilia: summary statement.
- 2003
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Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 9:Suppl 1, s. 41278-41278
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Tidskriftsartikel (refereegranskat)abstract
- Participants in an international conference on prophylactic therapy for severe haemophilia developed a consensus summary of the findings and conclusions of the conference. In the consensus, participants agreed upon revised definitions for primary and secondary prophylaxis and also made recommendations concerning the need for an international system of pharmacovigilance. Considerations on starting prophylaxis, monitoring outcomes, and individualizing treatment regimens were discussed. Several research questions were identified as needing further investigation, including when to start and when to stop prophylaxis, optimal dosing and dose interval, and methods for assessment of long-term treatment effects. Such studies should include carefully defined cohorts, validated orthopaedic and quality-of-life assessment instruments, and cost-benefit analyses.
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| 3. |
- Brown, S A, et al.
(författare)
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Unresolved issues in prophylaxis
- 2002
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Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 8:6, s. 817-821
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Ljung, R., et al.
(författare)
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Treatment of children with haemophilia in Europe: A survey of 20 centres in 16 countries
- 2000
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Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 6, s. 619-624
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Tidskriftsartikel (refereegranskat)abstract
- A survey was made of the current status of treatment of haemophilic boys at 20 centres in 16 European countries and includes approximately 1500 of the estimated 6500 haemophiliacs in the participating countries. Many mild haemophiliacs are not seen, or seen infrequently, at haemophilia centres and this requires study. Nine of 18 centres provide continuous prophylaxis to 80-100% of their patients, five centres provide it to 55-80% and the remaining four centres to 15-40% of the boys. The median dose given was 6240 U kg-1 year-1 (range 3120-7800). Four centres administered only recombinant concentrates to children with severe haemophilia A, while seven centres administered recombinant concentrates to 75-90% and the remaining centres to less than 50% of the boys (two centres <10%). When asked for the choice of concentrate for a newly diagnosed boy with severe haemophilia A, all but one centre preferred recombinant concentrate. Most boys below 6 years received concentrates via a peripheral vein but three centres preferred a central venous line for 80-100% of the boys. Thirteen of 18 centres applied home treatment to 84-100% of the boys and the remaining five centres to 57-77% of the boys.
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| 5. |
- Lucisano, Marco F. C., et al.
(författare)
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The role of evaporative dewatering in impulse pressing
- 2003
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Ingår i: Tappi Journal. - 0734-1415. ; 2:3, s. 26-32
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Tidskriftsartikel (refereegranskat)abstract
- The objective was to link heat transfer to water removal mechanisms, specifically evaporative dewatering, in impulse pressing experiments. Two independent laboratory devices - a platen press and a shoe press - were used to impulse press fiber webs made from softwood bleached kraft (SBK) over a range of basis weights (20-200 g/m2). In the platen press experiments, evaporative dewatering was evaluated by comparing the measured heat input to the amount of heat theoretically required to vaporize the water in excess of unheated wet pressing. Evaporative dewatering was found to be most pronounced for lightweight sheets, and enhanced dewatering can be attributed to this mechanism and other high-temperature mechanisms for basis weights above 60 g/m2. In the shoe press experiments, a composite sheet of five 30-g/m2 webs was used to evaluate profiles for resulting dryness, density, and water retention value (WRV) in the thickness direction. Evaporative effects were confined principally to the layer directly in contact with the heated surface. Application: A better understanding of the water removal mechanisms in impulse pressing process may accelerate the industrial application of impulse technology.
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