| 1. |
- Abolhassani, H, et al.
(författare)
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Care of patients with inborn errors of immunity in thirty J Project countries between 2004 and 2021
- 2022
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Ingår i: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 13, s. 1032358-
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Tidskriftsartikel (refereegranskat)abstract
- The J Project (JP) physician education and clinical research collaboration program was started in 2004 and includes by now 32 countries mostly in Eastern and Central Europe (ECE). Until the end of 2021, 344 inborn errors of immunity (IEI)-focused meetings were organized by the JP to raise awareness and facilitate the diagnosis and treatment of patients with IEI.ResultsIn this study, meeting profiles and major diagnostic and treatment parameters were studied. JP center leaders reported patients’ data from 30 countries representing a total population of 506 567 565. Two countries reported patients from JP centers (Konya, Turkey and Cairo University, Egypt). Diagnostic criteria were based on the 2020 update of classification by the IUIS Expert Committee on IEI. The number of JP meetings increased from 6 per year in 2004 and 2005 to 44 and 63 in 2020 and 2021, respectively. The cumulative number of meetings per country varied from 1 to 59 in various countries reflecting partly but not entirely the population of the respective countries. Altogether, 24,879 patients were reported giving an average prevalence of 4.9. Most of the patients had predominantly antibody deficiency (46,32%) followed by patients with combined immunodeficiencies (14.3%). The percentages of patients with bone marrow failure and phenocopies of IEI were less than 1 each. The number of patients was remarkably higher that those reported to the ESID Registry in 13 countries. Immunoglobulin (IgG) substitution was provided to 7,572 patients (5,693 intravenously) and 1,480 patients received hematopoietic stem cell therapy (HSCT). Searching for basic diagnostic parameters revealed the availability of immunochemistry and flow cytometry in 27 and 28 countries, respectively, and targeted gene sequencing and new generation sequencing was available in 21 and 18 countries. The number of IEI centers and experts in the field were 260 and 690, respectively. We found high correlation between the number of IEI centers and patients treated with intravenous IgG (IVIG) (correlation coefficient, cc, 0,916) and with those who were treated with HSCT (cc, 0,905). Similar correlation was found when the number of experts was compared with those treated with HSCT. However, the number of patients treated with subcutaneous Ig (SCIG) only slightly correlated with the number of experts (cc, 0,489) and no correlation was found between the number of centers and patients on SCIG (cc, 0,174).Conclusions1) this is the first study describing major diagnostic and treatment parameters of IEI care in countries of the JP; 2) the data suggest that the JP had tremendous impact on the development of IEI care in ECE; 3) our data help to define major future targets of JP activity in various countries; 4) we suggest that the number of IEI centers and IEI experts closely correlate to the most important treatment parameters; 5) we propose that specialist education among medical professionals plays pivotal role in increasing levels of diagnostics and adequate care of this vulnerable and still highly neglected patient population; 6) this study also provides the basis for further analysis of more specific aspects of IEI care including genetic diagnostics, disease specific prevalence, newborn screening and professional collaboration in JP countries.
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| 2. |
- Wilkinson, John L., et al.
(författare)
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Pharmaceutical pollution of the world's rivers
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:8
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Tidskriftsartikel (refereegranskat)abstract
- Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world's rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.
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| 3. |
- Apushkinskaya, D., et al.
(författare)
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Nina Nikolaevna Uraltseva
- 2022
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Ingår i: Notices of the American Mathematical Society. - : American Mathematical Society (AMS). - 0002-9920 .- 1088-9477. ; 69:03, s. 1-395
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Asratian, Armen, Professor, 1951-, et al.
(författare)
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Decomposing graphs into interval colorable subgraphs and no-wait multi-stage schedules
- 2023
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Ingår i: Discrete Applied Mathematics. - : ELSEVIER. - 0166-218X .- 1872-6771. ; 335, s. 25-35
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Tidskriftsartikel (refereegranskat)abstract
- A graph G is called interval colorable if it has a proper edge coloring with colors 1, 2, 3, ... such that the colors of the edges incident to every vertex of G form an interval of integers. Not all graphs are interval colorable; in fact, quite few families have been proved to admit interval colorings. In this paper we introduce and investigate a new notion, the interval coloring thickness of a graph G, denoted theta int(G), which is the minimum number of interval colorable edge-disjoint subgraphs of G whose union is G. Our investigation is motivated by scheduling problems with compactness require-ments, in particular, problems whose solution may consist of several schedules, but where each schedule must not contain any waiting periods or idle times for all involved parties. We first prove that every connected properly 3-edge colorable graph with maximum degree 3 is interval colorable, and using this result, we deduce an upper bound on theta int(G) for general graphs G. We demonstrate that this upper bound can be improved in the case when G is bipartite, planar or complete multipartite and consider some applications in timetabling.
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| 5. |
- Casselgren, Carl Johan, et al.
(författare)
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Improper interval edge colorings of graphs
- 2021
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Ingår i: Discrete Applied Mathematics. - : Elsevier. - 0166-218X .- 1872-6771. ; 305, s. 164-178
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Tidskriftsartikel (refereegranskat)abstract
- A k-improper edge coloring of a graph G is a mapping alpha : E(G) -> N such that at most k edges of G with a common endpoint have the same color. An improper edge coloring of a graph G is called an improper interval edge coloring if the colors of the edges incident to each vertex of G form an integral interval. In this paper we introduce and investigate a new notion, the interval coloring impropriety (or just impropriety) of a graph G defined as the smallest k such that G has a k-improper interval edge coloring; we denote the smallest such k by mu(int)(G). We prove upper bounds on mu(int)(G) for general graphs G and for particular families such as bipartite, complete multipartite and outerplanar graphs; we also determine mu(int)(G) exactly for G belonging to some particular classes of graphs. Furthermore, we provide several families of graphs with large impropriety; in particular, we prove that for each positive integer k, there exists a graph G with mu(int)(G) = k. Finally, for graphs with at least two vertices we prove a new upper bound on the number of colors used in an improper interval edge coloring. (C) 2021 The Author(s). Published by Elsevier B.V.
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