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| 2. |
- Wilking, N., et al.
(författare)
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Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy
- 2007
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:4, s. 694-700
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Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below theage of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years. Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633-1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665-1.129). Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS. © 2007 Oxford University Press.
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| 3. |
- Uher, J, et al.
(författare)
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Highly sensitive silicon detectors of thermal neutrons
- 2007
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Ingår i: Nuclear Science Symposium Conference Record, 2006. IEEE. Vol 3.. - : IEEE conference proceedings. - 1424405602 - 9781424405619 ; , s. 1346-1348
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Konferensbidrag (refereegranskat)abstract
- Planar semiconductor diodes supplemented with a layer of an appropriate neutron converter such as 6LiF can be used for thermal neutron counting or imaging. Neutrons interacting in the converter generate alphas and tritons which enter the semiconductor and are detected there. However, simple planar devices suffer from limited detection efficiency which cannot reach more than about 5%. The limit in detection efficiency can be overcome by etching a 3D microstructure of trenches, pores or columns in the detector and filling it with the neutron converter. The overall neutron detection efficiency of such structure with pores was simulated. The results indicate an increase in the detection efficiency by factor of 6 in comparison with a standard planar neutron detector. Samples with different silicon column sizes were fabricated to study the electrical properties of 3D structures. The charge collection efficiency in silicon columns from 10 μm to 800 μm wide and 80 μm high was measured. Single pad detectors with pores were also fabricated and tested for thermal neutron detection. The samples have square pores of 20 μm wide, ~60 μm deep. The pore pitch is 70 μm. 6LiF was used as the neutron converter in all cases. Pulse height spectra of the filled samples irradiated by thermal neutrons were measured. The measurement proved functionality of such detectors and its usability for thermal neutron detection.
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| 5. |
- Nilsson, Per, et al.
(författare)
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SCADA data and the quantification of hazardous events for QMRA
- 2007
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Ingår i: Journal of Water and Health. - : IWA Publishing. - 1477-8920 .- 1996-7829. ; 5, s. 99-105
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to assess the use of on-line monitoring to support the QMRA at water treatment plants studied in the EU MicroRisk project. SCADA data were obtained from diary records, grab three Catchment-to-Tap Systems (CTS) along with system descriptions, sample data and deviation reports. Particular attention was paid to estimating hazardous event frequency, duration and magnitude. Using Shewart and CUSUM we identified 'change-points' corresponding to events of between 10 min and > 1 month duration in timeseries data. Our analysis confirmed it is possible to quantify hazardous event durations from turbidity, chlorine residual and pH records and distinguish them from non-hazardous variability in the timeseries dataset. The durations of most 'events' were short-term (0.5-2.3 h). These data were combined with QMRA to estimate pathogen infection risk arising from such events as chlorination failure. its interpretation was While analysis of SCADA data alone could identify events provisionally, severely constrained in the absence of diary records and other system information. SCADA data analysis should only complement traditional water sampling, rather than replace it. More work on on-line data management, quality control and interpretation is needed before it can be used for event characterization routinely for event characterrisation.
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| 6. |
- Skorodko, T., et al.
(författare)
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Excitation of the Roper resonance in single- and double-pion production in nucleon-nucleon collisions
- 2008
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 35:3, s. 317-319
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Tidskriftsartikel (refereegranskat)abstract
- In most investigations the Roper resonance is sensed only very indirectly via complex partial-wave analyses. We find indications for its excitation in the invariant n pi(+) mass spectrum of the pp -> np pi(+) reaction at M approximate to 1360 MeV with a width of approximate to 150 MeV . The values fit very favorably to the most recent phase shift results as well as to the observations at BES. In the near-threshold two-pion production pp -> pp pi(0)pi(0) , where the Roper excitation and its subsequent decays via the routes N* -> Delta pi -> N pi pi and N* -> N sigma are the only dominant processes, we find its direct decay into the N sigma channel to be the by far dominating decay process -in favor of a monopole excitation of the Roper resonance.
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| 7. |
- Skovsted, Christian B., et al.
(författare)
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The scleritome of Paterimitra : an Early Cambrian stem group brachiopod from South Australia
- 2009
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Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 276:1662, s. 1651-1656
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Tidskriftsartikel (refereegranskat)abstract
- Early Cambrian tommotiids are problematic fossil metazoans with external organophosphatic sclerites that have been considered to be basal members of the lophophorate stem group. Tommotiids are almost exclusively known from isolated or rarely fused individual sclerites, which made previous reconstructions of the actual organism highly conjectural. However, the recent discovery of the first articulated specimens of the tommotiid Eccentrotheca revealed a tubular sclerite arrangement (scleritome) that limited the possible life habit to sessile filter feeding and thus further supported a lophophorate affinity. Here, we report the first articulated specimens of a second tommotiid taxon, Paterimitra from the Early Cambrian of the Arrowie Basin, South Australia. Articulated specimens of Paterimitra are composed of two bilaterally symmetrical sclerite types and an unresolved number of small, asymmetrical and irregular crescent-shaped sclerites that attached to the anterior margin of the symmetrical sclerites. Together, the sclerites form an open cone in which the symmetrical sclerites are joined together and form a small posterior opening near the base of the scleritome, while the irregular crescent-shaped sclerites defined a broad anterior opening. The coniform scleritome of Paterimitra is interpreted to have attached to hard substrates via a pedicle that emerged through the small posterior opening ( sometimes forming a tube) and was probably a sessile filter feeder. The scleritome of Paterimitra can be derived from the tubular scleritome of Eccentrotheca by modification of basal sclerites and reduction in tube height, and probably represents a more derived member of the brachiopod stem group with the paired symmetrical sclerites possibly homologous to brachiopod valves.
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