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- Alamaa, Linda, et al.
(författare)
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De reaktionära
- 2023
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Ingår i: Fronesis. ; :76-77, s. 8-16
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Fransén, Karin, 1973-, et al.
(författare)
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CRP levels are significantly associated with CRP genotype and estrogen use in The Lifestyle, Biomarker and Atherosclerosis (LBA) study
- 2022
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Ingår i: BMC Cardiovascular Disorders. - : BioMed Central. - 1471-2261 .- 1471-2261. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The C‑reactive protein (CRP) is an important biomarker for atherosclerosis and single nucleotide poly‑morphisms (SNPs) in the CRP locus have been associated with altered CRP levels and associated with risk for cardio‑vascular disease. However, the association between genetic variations in the CRP gene, estrogen use and CRP levels orearly signs of atherosclerosis in young healthy individuals is not fully characterized. We aimed to evaluate the influ‑ence of five genetic variants on both plasma CRP levels and carotid intima‑media thickness (cIMT) values, includingaspects on estrogen containing contraceptive use in females.Methods: Genotyping was performed with TaqMan real time PCR and compared with high sensitivity CRP serumlevels in 780 Swedish young, self‑reported healthy individuals. Haplotypes of the SNPs were estimated with the PHASEv 2.1. The cIMT was measured by 12 MHz ultrasound. The contraceptive use was self‑reported.Results: Strong associations between CRP and genotype were observed for rs3091244, rs1800947, rs1130864, andrs1205 in women (all p < 0.001). In men, only rs1800947 was associated with CRP (p = 0.029). The independent effectof genotypes on CRP remained significant also after adjustment for established risk factors. Female carriers of the H1/ATGTG haplotype had higher CRP than non‑carriers. This was specifically pronounced in the estrogen‑using group(p < 0.001), and they had also higher cIMT (p = 0.002) than non‑carriers but with a small cIMT difference between thehaplotype groups (0.02 mm). In parallel, a significant correlation between CRP and cIMT in the estrogen using groupwas observed (r = 0.194; p = 0.026).Conclusions: Estrogen use, genotypes and haplotypes in the CRP locus are significantly associated with CRP levels.Based on an observed interaction effect between sex/estrogen use and the H1/ATGTG haplotype on CRP, and amarginally thicker cIMT in the estrogen using group, our data suggest that both genotypes and estrogen usage couldbe involved in arterial wall structural differences. The causality between CRP levels and cIMT remains unclear, and theobserved difference in cIMT is not clinically relevant in the present state. Future larger and longitudinal studies mayshed further light on the role of more long‑term estrogen use and early atherosclerosis.
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| 6. |
- Hellblom, Anna, et al.
(författare)
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Malignant hyperthermia safety - A nationwide survey of publicly funded Swedish healthcare
- 2024
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Ingår i: Acta Anaesthesiologica Scandinavica. - 0001-5172. ; , s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundMalignant hyperthermia (MH) is a rare pharmacogenetic disorder that can lead to a life-threatening reaction during general anaesthesia with triggering agents. Prompt life-saving treatment includes the immediate administration of the antidote dantrolene. This study investigated Swedish healthcare providers' awareness and adherence to guidelines and recommendations with respect to MH and whether adherence to safe MH-praxis varies with hospital care-complexity level and private versus public management form.MethodAgreements and procurement specifications between all 21 Swedish County Councils and privately run surgical care providers were reviewed alongside with questionnaire-aided collection of information from 62 publicly funded health care providers (both privately and publicly run).ResultsNo procurement requirement specification or contract contained requirements on anaesthesia or aspects of MH. All publicly run hospitals stocked dantrolene and 28 out of 52 (54%) stocked the recommended amount. Seven out of nine (78%) of the privately run institutions stocked dantrolene, and one stocked the recommended amount. Publicly run hospitals adhered to recommendations to a greater extent than privately run institutions, both with respect to stocking of dantrolene (p = .02) and to stocking the recommended amount (p = .03).ConclusionsContracts between Swedish county councils and private surgical care subcontractors rarely outline expectations of standards for the safe practice of anaesthesia such as preparedness to handle a life-threatening MH reaction. Among Swedish publicly funded anaesthesia providers there is room for improvement in adherence to the EMHG guideline on dantrolene availability. Publicly run hospitals seem to have better compliance with these recommendations than privately run institutions. Raising awareness about current guidelines is important to improve safety for known and unknown MH-susceptible individuals.
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| 7. |
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Landsbygder
- 2022
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Pettersson, Carolina, et al.
(författare)
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Landsbygdernas värdeskapande : introduktion till avsnittets texter
- 2021
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Ingår i: Landsbygder. - Malmö, Sverige : Tidskriftsföreningen Fronesis. - 9789198556841 ; , s. 24-28
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Föreställningarna om landsbygdens roll i samhället är många och brokiga. Å ena sidan betraktas landsbygden som avskild och perifer, å andra sidan som en plats där fötterna står stadigt i myllan och där anknytning kan byggas mellan människan och platsen hon bor på. Å ena sidan beskylls landsbygden för att parasitera på de tillväxtgenererande storstäderna, för att vara "bidragsberoende" och "tillväxthämmad", eller för att skapa grogrund för reaktionära rörelser i motsats till den framåtsträvande och progressiva staden. Å andra sidan beskrivs landsbygden som en tillflyktsort för stressade storstadsmänniskor, som med sina annorlunda levnadsvanor vittnar om en ojämn ekonomisk-geografisk utveckling. Gemensamt för dessa föreställningar är att landsbygden får tjäna som stadens antites. Har landsbygden ett existensberättigande utanför denna binära relation? Kan landsbygden rymma något mer än sådana egenskaper som står i motsatsförhållande till dem som framhävs hos staden? Kan den rymma alla de ovanstående egenskaperna samtidigt? Är den samtidigt reaktionär, progressiv, fattig, rik, perifer, central, bidragsberoende, tillväxtgenererande, traditionell och modern?
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| 9. |
- Pettersson, Carolina, et al.
(författare)
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Zero Vibration Injuries—A Swedish Holistic Approach to Reduce Vibration Injury
- 2023
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Ingår i: Proceedings. - : MDPI. - 2504-3900. ; 86
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Tidskriftsartikel (refereegranskat)abstract
- Vibration injuries cause significant costs for society, great personal suffering, and often the relocation of personnel within a company. The project “Zero Vibration Injuries” is a Swedish initiative with the objective of taking a holistic approach to the problem, involving all stakeholders. The project’s vision is “Zero Vibration Injuries”. This is achieved by addressing the source of the problem by reducing the vibration levels in hand-held machines and applying the solutions in industry to the benefit of the users.
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