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Träfflista för sökning "WFRF:(Pfeffer MA) srt2:(2003-2004)"

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1.	Granger, BB, et al. (author) Adherence, even to placebo, is strongly and independently related to outcome in patients with chronic heart failure: Results from the CHARM program 2004 In: CIRCULATION. - 0009-7322. ; 110:17, s. 557-557 Conference paper (other academic/artistic)
2.	Granger, CB, et al. (author) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial 2003 In: Lancet (London, England). - 1474-547X. ; 362:9386, s. 772-776 Journal article (peer-reviewed)
3.	McMurray, JJV, et al. (author) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial 2003 In: Lancet (London, England). - 1474-547X. ; 362:9386, s. 767-771 Journal article (peer-reviewed)
4.	Pfeffer, MA, et al. (author) Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme 2003 In: Lancet (London, England). - 1474-547X. ; 362:9386, s. 759-766 Journal article (peer-reviewed)
5.	Pocock, SJ, et al. (author) Predicting mortality and morbidity in chronic heart failure independent of left ventricular systolic function: Results from the CHARM program 2004 In: CIRCULATION. - 0009-7322. ; 110:17, s. 752-752 Conference paper (other academic/artistic)
6.	Poy, MN, et al. (author) A pancreatic islet-specific microRNA regulates insulin secretion 2004 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 432:7014, s. 226-230 Journal article (peer-reviewed)abstract MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression(1). Several miRNAs in animals exhibit tissue-specific or developmental-stage-specific expression, indicating that they could play important roles in many biological processes(2-4). To study the role of miRNAs in pancreatic endocrine cells we cloned and identified a novel, evolutionarily conserved and islet-specific miRNA (miR-375). Here we show that overexpression of miR-375 suppressed glucose-induced insulin secretion, and conversely, inhibition of endogenous miR-375 function enhanced insulin secretion. The mechanism by which secretion is modified by miR-375 is independent of changes in glucose metabolism or intracellular Ca2+-signalling but correlated with a direct effect on insulin exocytosis. Myotrophin (Mtpn) was predicted to be and validated as a target of miR-375. Inhibition of Mtpn by small interfering (si) RNA mimicked the effects of miR-375 on glucose-stimulated insulin secretion and exocytosis. Thus, miR-375 is a regulator of insulin secretion and may thereby constitute a novel pharmacological target for the treatment of diabetes.
7.	Young, JB, et al. (author) Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials 2004 In: Circulation. - 1524-4539. ; 110:17, s. 2618-2626 Journal article (peer-reviewed)
8.	Young, JB, et al. (author) Reduction in all-cause mortality and morbidity with candesartan in patients with chronic heart failure and systolic left ventricular dysfunction: Results of the CHARM low 2004 In: JOURNAL OF CARDIAC FAILURE. - : Elsevier BV. - 1071-9164. ; 10:4, s. S76-S76 Conference paper (other academic/artistic)
9.	Yusuf, S, et al. (author) Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial 2003 In: Lancet (London, England). - 1474-547X. ; 362:9386, s. 777-781 Journal article (peer-reviewed)
10.	Yusuf, S, et al. (author) Impact of the angiotensin-receptor blocker candesartan in preventing diabetes in patients with heart failure 2004 In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - 0735-1097. ; 43:5, s. 473A-473A Conference paper (other academic/artistic)

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Result 1-10 of 10

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Type of publication: journal article (6); conference paper (4)

Type of content: peer-reviewed (6); other academic/artistic (4)

Author/Editor: Yusuf, S. (9); Swedberg, K (9); Pfeffer, MA (9); Granger, CB (9); Ostergren, J. (8); Michelson, EL (7); show more...; Olofsson, B (6); McMurray, JJV (6); Held, P. (5); Young, JB (2); Probstfield, JL (2); Dunlap, ME (2); Rorsman, Patrik (1); Eliasson, Lena (1); Mcmurray, JJ (1); McKelvie, RS (1); Ma, Xiaosong (1); Solomon, SD (1); Ekman, I. (1); Gerstein, H (1); MacDonald, Patrick (1); Cohen-Solal, A. (1); Dietz, R. (1); Pieper, KS (1); Wang, DL (1); Pocock, SJ (1); Stoffel, M. (1); Granger, BB (1); Zeneca, A (1); Kuch, J (1); Ostergren, JB (1); Poy, MN (1); Krutzfeldt, J (1); Kuwajima, S (1); Pfeffer, B (1); Tuschl, T (1); Rajewsky, N (1); Hradec, J (1); McKelvey, RS (1); McMurray, MJV (1); Michaelson, EL (1); show less...

University: Karolinska Institutet (9); Lund University (1)

Language: English (10)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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