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- Buckland, Paul C., et al.
(författare)
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Insect Remains from GUS : an interim report
- 1998
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Ingår i: Man, culture and environment in ancient Greenland. - Copenhagen : Danish National Museum & Danish Polar Center. - 8790369238 ; , s. 74-79
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Jorgensen, F S, et al.
(författare)
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MULTISCAN--a Scandinavian multicenter second trimester obstetric ultrasound and serum screening study
- 1999
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - 1600-0412. ; 78:6, s. 501-510
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To study the detection rates of second trimester ultrasound screening for neural tube defects (NTD), abdominal wall defects (AWD) and Down's syndrome (DS) in low risk populations at tertiary centers, and to compare the ultrasound screening detection rates with those that were obtainable by biochemical serum screening (double test: alpha-fetoprotein/human chorion gonadotrophin/age test). STUDY DESIGN: Prospective multicenter study with a three year inclusion period: 1/1/1989-31/12/1991. SUBJECTS: 27,844 low-risk women at 18-34 years of age who had a second trimester ultrasound screening examination. Of these, 10,264 also had a serum test. METHODS: An ultrasound malformation scan and a serum test were carried out at 17-19 weeks of gestation. Risk calculations regarding DS were based on alpha-fetoprotein, human chorion gonadotrophin and maternal age; performed retrospectively for the first two years. RESULTS: In total 73 cases were identified in the study population: NTD (n=34), AWD (n=7) and DS (n=32). The detection rates, (%, with 95% confidence interval) for ultrasound screening were: NTD: 79.4 (62.1-91.3); AWD: 85.7 (42.1-99.6); DS: 6.3 (0.8-20.8). In the subgroup of women who had both tests, the detection rates for ultrasound screening vs double test were: NTD: 62.5 (24.5-91.5) vs 75.0 (34.9-96.8); AWD: 66.7 (9.4-99.2) vs 100 (29.2-100.0); DS: 7.7 (0.2-36.0) vs 46.2 (19.2-74.9). The false positive rates (%) for ultrasound screening vs double test were: NTD: 0.01/3.3; AWD: 0.01/3.3; DS: 0.1/4.0. CONCLUSION: Second trimester ultrasound screening in a low risk population gave a low detection rate for fetal DS (6.3%) and an acceptable detection rate for NTD (79.4%) and AWD (85.7%). In the subgroup of women who had both tests, serum screening performed better than ultrasound as applied in the present study, especially regarding DS.
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- Lundberg, Peter, et al.
(författare)
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1H NMR determination of urinary betaine in patients with premature vascular disease and mild homocysteinemia
- 1995
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Ingår i: Clinical Chemistry. - 0009-9147 .- 1530-8561. ; 41:2, s. 275-283
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Tidskriftsartikel (refereegranskat)abstract
- Urinary N,N,N-trimethylglycine (betaine) and N,N-dimethylglycine (DMG) have been identified and quantified for clinical purposes by proton nuclear magnetic resonance (1H NMR) measurement in previous studies. We have assessed these procedures by using both one-dimensional (1-D) and 2-D NMR spectroscopy, together with pH titration of urinary extracts to help assign 1H NMR spectral peaks. The betaine calibration curve linearity was excellent (r = 0.997, P = 0.0001) over the concentration range 0.2-1.2 mmol/L, and CVs for replicate betaine analyses ranged from 7% (n = 10) at the lowest concentration to 1% (n = 9) at the highest. The detection limit for betaine was < 15 mumol/L. Urinary DMG concentrations were substantially lower than those of betaine. Urinary betaine and DMG concentrations measured by 1H NMR spectroscopy from 13 patients with premature vascular disease and 17 normal controls provided clinically pertinent data. We conclude that 1H NMR provides unique advantages as a research tool for determination of urinary betaine and DMG concentrations.
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| 9. |
- Rakov, Vladimir A., et al.
(författare)
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Mechanism of the lightning M component
- 1995
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Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 100:D12, s. 25701-25710
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Tidskriftsartikel (refereegranskat)abstract
- Analysis of simultaneous measurements of the channel-base current and the vertical electric field 30 m from triggered lightning reveals that the fields associated with M components, although essentially electrostatic, appear to be proportional to the time derivatives of the associated M currents. Based on this finding, coupled with other observations and modeling, a mechanism for the lightning M component is proposed. According to this mechanism an M component involves a downward progressing incident wave (the analog of a leader) followed by an upward progressing reflected wave (the analog of a return stroke). However, as opposed to a leader-return stroke sequence in which the latter removes the charge deposited by the former, both the upward and the downward processes contribute about equally to the total charge flowing from the bottom of the channel at any instant of time. Such a mode of charge transfer to ground, distinctly different from a leader-return stroke sequence, is possible because of the presence of a path capable of supporting the propagation of a traveling wave (facilitated by a continuing current flowing to ground) and the fact that the ground is essentially a short circuit for the downward incident wave, so that the magnitude of the current reflection coefficient at ground is virtually equal to unity. We show that some observed properties of M components can be explained if the lightning channel traversed by an M-current wave is represented as a linear R-C transmission line. In this view, the preferential attenuation of the higher-frequency components on an R-C line is responsible for the lack of frequencies above several kilohertz in both the M-current pulses measured at the channel base and the M-light pulses observed in the bottom 1 km or so of the channel. Further, the relatively high characteristic impedance of the channel, of the order of tens to hundreds of kilohms for frequencies below some kilohertz, inferred from the linear R-C line approximation, is consistent with the observation that even a relatively poor ground is sensed by an incident M wave as essentially a short circuit. However, on a linear R-C transmission line the higher-frequency components travel faster than lower-frequency components (this velocity dispersion implying that the original pulse would spread while propagating along the line), whereas the shape of the M-light pulses does not change much within the bottom 1 km or so, as if the channel were a distortionless transmission line. We speculate, on physical grounds, that the front of the traveling M-current pulse heats the channel so that the pulse tail encounters a lowered resistance and, as a result, accelerates. By virtue of these two opposing effects, velocity dispersion and channel nonlinearity, an M pulse is formed whose more-or-less symmetrical shape is preserved over a relatively large distance, as in the case of a soliton.
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