| 1. |
- Bousquet, J. Jean, et al.
(författare)
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Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases
- 2019
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Ingår i: Clinical and Translational Allergy. - : BMC. - 2045-7022 .- 2045-7022. ; 9
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Forskningsöversikt (refereegranskat)abstract
- Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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| 2. |
- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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| 3. |
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| 4. |
- Ots, Mart, 1973-, et al.
(författare)
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Press subsidies
- 2018
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Ingår i: Oxford Research Encyclopedia of Communication. - : Oxford University Press.
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Bokkapitel (refereegranskat)abstract
- Due to its function as a watchdog or fourth estate in democratic societies and a variety of commercial challenges, policy-makers have undertaken initiatives to support the production and distribution of news. Press subsidies are one such policy initiative that particularly aims to provide support to private news producers. Paid as direct cash handouts or indirect reduced taxes and fees, they exist in some form in almost every country in the world. Subsidies are not uncontroversial, their effectiveness is unclear, and their magnitude, designs, and areas of application, differ across nations and their unique economic, cultural, and political contexts.After periods of declining political and public interest in media subsidies, the recent economic crisis of journalism, and the rising influence of various forms of click-bait, fake, native, or biased news on social media platforms, has brought state support of original journalism back on the agenda.
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| 5. |
- Picard, Robert G., et al.
(författare)
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Sweden
- 2016
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Ingår i: Who Owns the World's Media? Media Concentration and Ownership around the World. - Oxford : Oxford University Press. - 9780199987238 ; , s. 338-357
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Bokkapitel (refereegranskat)
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| 6. |
- Sayed, Zehra
(författare)
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Postcolonial perspective on international knowledge transfer and spillover to Indian news media : From institutional duality to third space
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis examines the ways in which postcolonial ambivalence – a symptomatic condition of postcolonial societies in which they simultaneously embrace and reject the cultural, political and economic processes and expressions of the “ex-colonizer” – plays out in current globalization. This dialectic may be particularly apparent in the transfer of knowledge from developed-country MNCs to subsidiaries located in formerly colonized, now developing countries. It may also play a prominent role in the spillover of such knowledge onto local industries. Mainstream studies in these two fields, however, converge on the argument that institutional differences between the MNC’s home country and the subsidiary context – institutional duality – plays a key role in explaining knowledge transfer and spillover, in particular the failure of these processes. Such conceptualizations, however, deprive supposed knowledge recipients of agency. The work of postcolonial scholar Homi Bhabha, on the other hand, shows that when meeting the (ex-)colonizer, postcolonial subjects may draw on both cultures to create hybrid expressions. Rather than stressing the negative effects of differences between institutional logics, this conceptualization allows for the potential of innovation in encounters between cultures in what can be referred to as a third space that does not fully represent the MNC or the local context.Drawing on Homi Bhabha, I perform an interview-based study of Reuters’ transfer of knowledge of news gathering practices to its Indian subsidiaries in Mumbai and Bangalore. I also undertake an interview study of knowledge spillover among practitioners in Mumbai’s news media.The study on knowledge transfer shows how, in a process of mimicry, postcolonial subjects aspire to, reinterpret, adopt, reject but are also unable to internalize and implement knowledge in its entirety. The result may be hybridization of MNC knowledge, finding expression in hybrid values, practices and work outcomes. In the study on knowledge spillover, I find that foreign knowledge enters a political space where debates on FDI and existing local practices influence spillover process and outcomes. When mimicking Western practices locals take a reflective stance where local and foreign values and practices are critically examined and applied in discerning fashion – selective spillover. These findings lead me to suggest that, rather than viewing processes of globalization in a celebratory-bleak binary framework, future research should consider the dialectic between the power of MNCs and the agency of local actors to subvert that power. This dialectic may potentially be captured by considering the institutional situatedness of both Western and local knowledge rather than automatically assuming the superiority of the former over the latter.
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| 7. |
- Torchia, Jonathon, et al.
(författare)
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Molecular subgroups of atypical teratoid rhabdoid tumours in children : an integrated genomic and clinicopathological analysis
- 2015
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Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 16:5, s. 569-582
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Tidskriftsartikel (refereegranskat)abstract
- Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of biological understanding of the substantial clinical heterogeneity of these tumours restricts therapeutic advances. We integrated genomic and clinicopathological analyses of a cohort of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical heterogeneity in these tumours. Methods We obtained 259 rhabdoid tumours from 37 international institutions and assessed transcriptional profiles in 43 primary tumours and copy number profiles in 38 primary tumours to discover molecular subgroups of atypical teratoid rhabdoid tumours. We used gene and pathway enrichment analyses to discover group-specific molecular markers and did immunohistochemical analyses on 125 primary tumours to evaluate clinicopathological significance of molecular subgroup and ASCL1-NOTCH signalling. Findings Transcriptional analyses identified two atypical teratoid rhabdoid tumour subgroups with differential enrichment of genetic pathways, and distinct clinicopathological and survival features. Expression of ASCL1, a regulator of NOTCH signalling, correlated with supratentorial location (p=0.004) and superior 5-year overall survival (35%, 95% CI 13-57, and 20%, 6-34, for ASCL1-positive and ASCL1-negative tumours, respectively; p=0.033) in 70 patients who received multimodal treatment. ASCL1 expression also correlated with superior 5-year overall survival (34%, 7-61, and 9%, 0-21, for ASCL1-positive and ASCL1-negative tumours, respectively; p=0.001) in 39 patients who received only chemotherapy without radiation. Cox hazard ratios for overall survival in patients with differential ASCL1 enrichment treated with chemotherapy with or without radiation were 2.02 (95% CI 1.04-3.85; p=0.038) and 3.98 (1.71-9.26; p=0.001). Integrated analyses of molecular subgroupings with clinical prognostic factors showed three distinct clinical risk groups of tumours with different therapeutic outcomes. Interpretation An integration of clinical risk factors and tumour molecular groups can be used to identify patients who are likely to have improved long-term radiation-free survival and might help therapeutic stratification of patients with atypical teratoid rhabdoid tumours.
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| 8. |
- Treasure, Anne M., et al.
(författare)
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Marine Mammals Exploring the Oceans Pole to Pole A Review of the MEOP Consortium
- 2017
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Ingår i: Oceanography. - : The Oceanography Society. - 1042-8275. ; 30:2, s. 132-138
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Tidskriftsartikel (refereegranskat)abstract
- Polar oceans are poorly monitored despite the important role they play in regulating Earth's climate system. Marine mammals equipped with biologging devices are now being used to fill the data gaps in these logistically difficult to sample regions. Since 2002, instrumented animals have been generating exceptionally large data sets of oceanographic CTD casts (>500,000 profiles), which are now freely available to the scientific community through the MEOP data portal (http://meop.net). MEOP (Marine Mammals Exploring the Oceans Pole to Pole) is a consortium of international researchers dedicated to sharing animal-derived data and knowledge about the polar oceans. Collectively, MEOP demonstrates the power and cost-effectiveness of using marine mammals as data-collection platforms that can dramatically improve the ocean observing system for biological and physical oceanographers. Here, we review the MEOP program and database to bring it to the attention of the international community.
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