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- Vernet, Nicolas, et al.
(författare)
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Experimental determination of the permeability of engineering textiles : Benchmark II
- 2014
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Ingår i: Composites. Part A, Applied science and manufacturing. - : Elsevier Ltd. - 1359-835X .- 1878-5840. ; 61, s. 172-184
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Tidskriftsartikel (refereegranskat)abstract
- In this second international permeability benchmark, the in-plane permeability values of a carbon fabric were studied by twelve research groups worldwide. One participant also investigated the deformation of the tested carbon fabric. The aim of this work was to obtain comparable results in order to make a step toward standardization of permeability measurements. Unidirectional injections were thus conducted to determine the unsaturated in-plane permeability tensor of the fabric. Procedures used by participants were specified in the guidelines defined for this benchmark. Participants were asked to use the same values for parameters such as fiber volume fraction, injection pressure and fluid viscosity to minimize sources of scatter. The comparison of the results from each participant was encouraging. The scatter between data obtained while respecting the guidelines was below 25%. However, a higher dispersion was observed when some parameters differed from the recommendations of this exercise.
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- Thekkilakattil, Abhilash, et al.
(författare)
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Reducing the Number of Preemptions in Real-Time Systems Scheduling by CPU Frequency Scaling
- 2010
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Ingår i: 18th International Conference on Real-Time and Network Systems. - Toulouse, France.
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Konferensbidrag (refereegranskat)abstract
- Controlling the number of preemptions in real-time systems is highly desirable in order to achieve an efficient system design in multiple contexts. For example, the delays due to context switches account for high preemption overheads which detrimentally impact the system schedulability. Preemption avoidance can also be potentially used for the efficient control of critical section behaviors in multi-threaded applications. At the same time, modern processor architectures provide for the ability to selectively choose operating frequencies, primarily targeting energy efficiency as well as system performance. In this paper, we propose the use of CPU Frequency Scaling for controlling the preemptive behavior of real-time tasks. We present a framework for selectively eliminating preemptions, that does not require modifications to the task attributes or to the underlying scheduler. We evaluate the proposed approach by four different heuristics through extensive simulation studies.
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- Wilkins, Justin J., et al.
(författare)
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Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients
- 2011
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Ingår i: British Journal of Clinical Pharmacology. - : Wiley. - 0306-5251 .- 1365-2125. ; 72:1, s. 51-62
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Tidskriftsartikel (refereegranskat)abstract
- AIM This study was designed to characterize the population pharmacokinetics of isoniazid in South African pulmonary tuberculosis patients. METHODS Concentration-time measurements obtained from 235 patients receiving oral doses of isoniazid as part of routine tuberculosis chemotherapy in two clinical studies were pooled and subjected to nonlinear mixed-effects analysis. RESULTS A two-compartmental model, including first-order absorption and elimination with allometric scaling, was found to describe the observed dose-exposure relationship for oral isoniazid adequately. A mixture model was used to characterize dual rates of isoniazid elimination. Estimates of apparent clearance in slow and fast eliminators were 9.70 and 21.6 l h(-1), respectively. The proportion of fast eliminators in the population was estimated to be 13.2%. Central volume of distribution was estimated to be 10% smaller in female patients and clearance was found to be 17% lower in patients with HIV. Variability in absorption rate (90%) was completely interoccasional in nature, whereas in relative bioavailability, interoccasional variability (8.4%) was lower than interindividual variability (26%). Oral doses, given once daily according to dosing policies at the time, were sufficient to reach therapeutic concentrations in the majority of the studied population, regardless of eliminator phenotype. Simulations suggested that current treatment guidelines (5 mg kg(-1)) may be suboptimal in fast eliminators with low body weight. CONCLUSIONS A population pharmacokinetic model was developed to characterize the highly variable pharmacokinetics of isoniazid in a South African pulmonary tuberculosis patient population. Current treatment guidelines may lead to underexposure in rapid isoniazid eliminators.
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