| 1. |
|
|
| 2. |
- Gianfagna, Francesco, et al.
(författare)
-
Understanding the Links among neuromedin U Gene, beta2-adrenoceptor Gene and Bone Health: An Observational Study in European Children.
- 2013
-
Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:8
-
Tidskriftsartikel (refereegranskat)abstract
- Neuromedin U, encoded by the NMU gene, is a hypothalamic neuropeptide that regulates both energy metabolism and bone mass. The beta-2 adrenergic receptor, encoded by the ADRB2 gene, mediates several effects of catecholamine hormones and neurotransmitters in bone. We investigated whether NMU single nucleotide polymorphisms (SNPs) and haplotypes, as well as functional ADRB2 SNPs, are associated with bone stiffness in children from the IDEFICS cohort, also evaluating whether NMU and ADRB2 interact to affect this trait. A sample of 2,274 subjects (52.5% boys, age 6.2±1.8 years) from eight European countries, having data on calcaneus bone stiffness index (SI, mean of both feet) and genotyping (NMU gene: rs6827359, rs12500837, rs9999653; ADRB2 gene: rs1042713, rs1042714), was studied. After false discovery rate adjustment, SI was significantly associated with all NMU SNPs. rs6827359 CC homozygotes showed the strongest association (recessive model, Δ=-1.8, p=0.006). Among the five retrieved haplotypes with frequencies higher than 1% (range 2.0-43.9%), the CCT haplotype (frequency=39.7%) was associated with lower SI values (dominant model, Δ=-1.0, p=0.04) as compared to the most prevalent haplotype. A non-significant decrease in SI was observed in in ADRB2 rs1042713 GG homozygotes, while subjects carrying SI-lowering genotypes at both SNPs (frequency=8.4%) showed much lower SI than non-carriers (Δ=-3.9, p<0.0001; p for interaction=0.025). The association was more evident in preschool girls, in whom SI showed a curvilinear trend across ages. In subgroup analyses, rs9999653 CC NMU or both GG ADRB2 genotypes were associated with either lower serum calcium or β-CrossLaps levels (p=0.01). This study in European children shows, for the first time in humans, a role for NMU gene through interaction with ADRB2 gene in bone strength regulation, more evident in preschool girls.
|
|
| 3. |
- Jiménez-Pavón, David, et al.
(författare)
-
Physical activity and clustered cardiovascular disease risk factors in young children : a cross-sectional study (the IDEFICS study)
- 2013
-
Ingår i: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The relevance of physical activity (PA) for combating cardiovascular disease (CVD) risk in children has been highlighted, but to date there has been no large-scale study analyzing that association in children aged ≤9 years of age. This study sought to evaluate the associations between objectively-measured PA and clustered CVD risk factors in a large sample of European children, and to provide evidence for gender-specific recommendations of PA.METHODS: Cross-sectional data from a longitudinal study in 16,224 children aged 2 to 9 were collected. Of these, 3,120 (1,016 between 2 to 6 years, 2,104 between 6 to 9 years) had sufficient data for inclusion in the current analyses. Two different age-specific and gender-specific clustered CVD risk scores associated with PA were determined. First, a CVD risk factor (CRF) continuous score was computed using the following variables: systolic blood pressure (SBP), total triglycerides (TG), total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-c) ratio, homeostasis model assessment of insulin resistance (HOMA-IR), and sum of two skinfolds (score CRFs). Secondly, another CVD risk score was obtained for older children containing the score CRFs + the cardiorespiratory fitness variable (termed score CRFs + fit). Data used in the current analysis were derived from the IDEFICS ('Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS') study.RESULTS: In boys <6 years, the odds ratios (OR) for CVD risk were elevated in the least active quintile of PA (OR: 2.58) compared with the most active quintile as well as the second quintile for vigorous PA (OR: 2.91). Compared with the most active quintile, older children in the first, second and third quintiles had OR for CVD risk score CRFs + fit ranging from OR 2.69 to 5.40 in boys, and from OR 2.85 to 7.05 in girls.CONCLUSIONS: PA is important to protect against clustering of CVD risk factors in young children, being more consistent in those older than 6 years. Healthcare professionals should recommend around 60 and 85 min/day of moderate-to-vigorous PA, including 20 min/day of vigorous PA.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/173.
|
|
| 4. |
- Ojiambo, Robert, et al.
(författare)
-
Validity of hip-mounted uniaxial accelerometry with heart-rate monitoring vs. triaxial accelerometry in the assessment of free-living energy expenditure in young children: the IDEFICS Validation Study
- 2012
-
Ingår i: Journal of applied physiology (Bethesda, Md. : 1985). - : American Physiological Society. - 1522-1601 .- 8750-7587. ; 113:10, s. 1530-1536
-
Tidskriftsartikel (refereegranskat)abstract
- One of the aims of Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants (IDEFICS) validation study is to validate field measures of physical activity (PA) and Energy expenditure (EE) in young children. This study compared the validity of uni-axial accelerometry with heart-rate (HR) monitoring vs. tri-axial accelerometry against doubly labeled water (DLW) criterion method for assessment of free-living EE in young children. 49 European children (25 female, 24 male) aged 4-10 years (mean age 7 ± 2 years) were assessed by uni-axial ActiTrainer with HR, uni-axial 3DNX and tri-axial 3DNX accelerometry. Total energy expenditure (TEE) was estimated using DLW over a 1 week period. The longitudinal axis of both devices and tri-axial 3DNX counts per minute (CPM) were significantly (P<0.05) associated with physical activity level (PAL) (r = 0.51 ActiTrainer, r = 0.49 uni-axial-3DNX and r = 0.42 tri-axial ∑3DNX). 86% of the variance in TEE could be predicted by a model combining body mass (Partial r(2) = 71%; P<0.05), CPM-ActiTrainer (Partial r(2) = 11%; P<0.05) and difference between HR at moderate and sedentary activities (ModHR - SedHR; Partial r(2) = 4%; P<0.05) The standard error (S.E) of TEE estimate for ActiTrainer and 3DNX models ranged from 0.44-0.74 MJ/d or approximately 7-11% of the average TEE. The S.E of activity-induced energy expenditure (AEE) model estimates ranged from 0.38-0.57 MJ/d or 24-26% of the average AEE. It is concluded that the comparative validity of hip-mounted uni-axial and tri-axial accelerometers for assessing PA and EE is similar.
|
|
