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Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction : A Mendelian Randomization Study

Rukh, Gull (författare)
Uppsala universitet,Institutionen för kirurgiska vetenskaper
Ahmad, Shafqat (författare)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Brigham & Womens Hosp, Harvard Med Sch, Prevent Med Div, Boston, MA USA.
Lind, Lars (författare)
Uppsala universitet,Kardiologi
visa fler...
Schioth, Helgi Birgir (författare)
Uppsala universitet,Institutionen för kirurgiska vetenskaper
visa färre...
 (creator_code:org_t)
2022-04-28
2022
Engelska.
Ingår i: Frontiers in Genetics. - : Frontiers Media S.A.. - 1664-8021. ; 13
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Epidemiological studies have provided extensive evidence regarding the role of psychological risk factors in the pathogenesis of cardiovascular disease (CVD), but whether these associations are causal in nature is still unknown. We aimed to investigate whether the association between the wellbeing spectrum (WBS; derived from four psychological traits including life satisfaction, positive affect, neuroticism, and depressive symptoms) and CVD risk is causal. By employing a two-sample Mendelian randomization (MR) approach, the effect of the WBS on four CVD outcomes, including atrial fibrillation, heart failure, myocardial infarction, and ischemic stroke, was investigated. The genetically predicted WBS was associated with 38% lower risk for heart failure (odds ratio (OR): 0.62; 95% confidence interval [CI]: 0.50-0.78; P: 2.2 x 10(-5)) and 40% reduced risk of myocardial infarction (OR: 0.60; 95% CI: 0.47-0.78; P: 1.1 x 10(-4)). Of the WBS constituent traits, only depressive symptoms showed a positive causal association with heart failure and myocardial infarction. Neither WBS nor WBS constituent traits were associated with atrial fibrillation and ischemic stroke. In multivariable MR analyses, when genetic instruments for traditional CVD risk factors were also taken into consideration, the WBS was causally associated with a reduced risk for heart failure (OR: 0.72; 95% CI: 0.58-0.88; P: 0.001) and myocardial infarction (OR: 0.67; 95% CI: 0.52-0.86; P: 0.002). This study provides evidence that a higher WBS is causally associated with a decreased risk of developing CVD and, more specifically, myocardial infarction; moreover, the association is mainly driven by depressive symptoms. These results support current guidelines that suggest improving psychological wellbeing may help in reducing the burden of cardiovascular disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

wellbeing
cardiovascular disease
Mendelian randomization
depressive symptoms
neuroticism
positive affect
life satisfaction

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Rukh, Gull
Ahmad, Shafqat
Lind, Lars
Schioth, Helgi B ...
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