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Migratory and anti-...
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
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- Poch, Christine M (author)
- Tech Univ Munich, Germany
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- Foo, Kylie S (author)
- Karolinska Inst, Sweden; Karolinska Inst, Sweden,Munich Univ Appl Sci, Germany
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- De Angelis, Maria Teresa (author)
- Tech Univ Munich, Germany; Tech Univ Munich, Germany
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- Jennbacken, Karin (author)
- AstraZeneca, Sweden
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- Santamaria, Gianluca (author)
- Tech Univ Munich, Germany; Tech Univ Munich, Germany
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- Bähr, Andrea (author)
- Tech Univ Munich, Germany
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- Wang, Qing-Dong (author)
- AstraZeneca, Sweden
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- Reiter, Franziska (author)
- Tech Univ Munich, Germany
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- Hornaschewitz, Nadja (author)
- Tech Univ Munich, Germany
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- Zawada, Dorota (author)
- Tech Univ Munich, Germany; Tech Univ Munich, Germany
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- Bozoglu, Tarik (author)
- Tech Univ Munich, Germany
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- My, Ilaria (author)
- Tech Univ Munich, Germany
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- Meier, Anna (author)
- Tech Univ Munich, Germany; Tech Univ Munich, Germany
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- Dorn, Tatjana (author)
- Tech Univ Munich, Germany; Tech Univ Munich, Germany
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- Hege, Simon (author)
- Tech Univ Munich, Germany
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- Lehtinen, Miia L (author)
- Karolinska Inst, Sweden
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- Tsoi, Yat Long (author)
- Karolinska Inst, Sweden
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- Hovdal, Daniel (author)
- AstraZeneca, Sweden
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- Hyllner, Johan, 1962- (author)
- Linköpings universitet,Biofysik och bioteknik,Tekniska fakulteten,AstraZeneca, Sweden
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Schwarz, Sascha (author)
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Sudhop, Stefanie (author)
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- Jurisch, Victoria (author)
- Tech Univ Munich, Germany
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- Sini, Marcella (author)
- AstraZeneca, England
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- Fellows, Mick D (author)
- AstraZeneca, England
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- Cummings, Matthew (author)
- Western Michigan Sch Med, MI USA
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- Clarke, Jonathan (author)
- Procella Therapeut, Sweden
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- Baptista, Ricardo (author)
- Procella Therapeut, Sweden
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- Eroglu, Elif (author)
- Karolinska Institutet
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- Wolf, Eckhard (author)
- Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany
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- Klymiuk, Nikolai (author)
- Tech Univ Munich, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Lu, Kun (author)
- Ludwig Maximilians Univ Munchen, Germany
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- Tomasi, Roland (author)
- Ludwig Maximilians Univ Munchen, Germany
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- Dendorfer, Andreas (author)
- DZHK German Ctr Cardiovasc Res, Germany; Ludwig Maximilians Univ Munchen, Germany
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- Gaspari, Marco (author)
- Univ Magna Grecia, Italy
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- Parrotta, Elvira (author)
- Univ Magna Grecia, Italy
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- Cuda, Giovanni (author)
- Univ Magna Grecia, Italy
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- Krane, Markus (author)
- DZHK German Ctr Cardiovasc Res, Germany; Tech Univ Munich, Germany
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- Sinnecker, Daniel (author)
- Tech Univ Munich, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Hoppmann, Petra (author)
- Tech Univ Munich, Germany
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- Kupatt, Christian (author)
- Tech Univ Munich, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Fritsche-Danielson, Regina (author)
- AstraZeneca, Sweden
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- Moretti, Alessandra (author)
- Tech Univ Munich, Germany; Tech Univ Munich, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Chien, Kenneth R (author)
- Karolinska Institutet
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- Laugwitz, Karl-Ludwig (author)
- Tech Univ Munich, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- ISSN 1465-7392
- 2022-05-12
- 2022
- English.
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In: Nature Cell Biology. - Stockholm : Karolinska Institutet, Dept of Cell and Molecular Biology. - 1465-7392 .- 1476-4679.
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft crosstalk remains elusive. Here, by combining lineage tracing and single-cell transcriptomics in injured non-human primate heart biomimics, we uncover the coordinated action modes of human progenitor-mediated muscle repair. Chemoattraction via CXCL12/CXCR4 directs cellular migration to injury sites. Activated fibroblast repulsion targets fibrosis by SLIT2/ROBO1 guidance in organizing cytoskeletal dynamics. Ultimately, differentiation and electromechanical integration lead to functional restoration of damaged heart muscle. In vivo transplantation into acutely and chronically injured porcine hearts illustrated CXCR4-dependent homing, de novo formation of heart muscle, scar-volume reduction and prevention of heart failure progression. Concurrent endothelial differentiation contributed to graft neovascularization. Our study demonstrates that inherent developmental programmes within cardiac progenitors are sequentially activated in disease, enabling the cells to sense and counteract acute and chronic injury.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Poch, Christine ...
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Foo, Kylie S
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De Angelis, Mari ...
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Jennbacken, Kari ...
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Santamaria, Gian ...
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Bähr, Andrea
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show more...
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Wang, Qing-Dong
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Reiter, Franzisk ...
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Hornaschewitz, N ...
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Zawada, Dorota
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Bozoglu, Tarik
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My, Ilaria
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Meier, Anna
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Dorn, Tatjana
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Hege, Simon
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Lehtinen, Miia L
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Tsoi, Yat Long
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Hovdal, Daniel
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Hyllner, Johan, ...
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Schwarz, Sascha
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Sudhop, Stefanie
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Jurisch, Victori ...
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Sini, Marcella
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Fellows, Mick D
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Cummings, Matthe ...
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Clarke, Jonathan
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Baptista, Ricard ...
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Eroglu, Elif
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Wolf, Eckhard
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Klymiuk, Nikolai
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Lu, Kun
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Tomasi, Roland
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Dendorfer, Andre ...
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Gaspari, Marco
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Parrotta, Elvira
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Cuda, Giovanni
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Krane, Markus
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Sinnecker, Danie ...
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Hoppmann, Petra
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Kupatt, Christia ...
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Fritsche-Daniels ...
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Moretti, Alessan ...
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Chien, Kenneth R
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Laugwitz, Karl-L ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Cell Biol ...
- By the university
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Karolinska Institutet
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Linköping University