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Factors associated ...
Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
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Yeoh, SA (författare)
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Gianfrancesco, M (författare)
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Lawson-Tovey, S (författare)
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visa fler...
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Hyrich, KL (författare)
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Strangfeld, A (författare)
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Gossec, L (författare)
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Carmona, L (författare)
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Mateus, EF (författare)
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Schafer, M (författare)
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Richez, C (författare)
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Hachulla, E (författare)
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- Holmqvist, M (författare)
- Karolinska Institutet
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Scire, CA (författare)
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Lorenz, HM (författare)
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Voll, RE (författare)
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Hasseli, R (författare)
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Jayatilleke, A (författare)
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Hsu, TYT (författare)
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D'Silva, KM (författare)
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Pimentel-Quiroz, VR (författare)
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del Mercado, MV (författare)
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Shinjo, SK (författare)
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Neto, ETD (författare)
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da Rocha, LF (författare)
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Montandon, ACDES (författare)
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Pons-Estel, GJ (författare)
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Ornella, S (författare)
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Exeni, MED (författare)
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Velozo, E (författare)
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Jordan, P (författare)
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Sirotich, E (författare)
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Hausmann, JS (författare)
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Liew, JW (författare)
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Jacobsohn, L (författare)
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Gore-Massy, M (författare)
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Sufka, P (författare)
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Grainger, R (författare)
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Bhana, S (författare)
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Wallace, Z (författare)
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Robinson, PC (författare)
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Yazdany, J (författare)
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Machado, PM (författare)
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(creator_code:org_t)
- 2022-09-13
- 2022
- Engelska.
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Ingår i: RMD open. - : BMJ. - 2056-5933. ; 8:2
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM).MethodsDemographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death.ResultsOf 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65–1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51–0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively).ConclusionsThis is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM.
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Yeoh, SA
-
Gianfrancesco, M
-
Lawson-Tovey, S
-
Hyrich, KL
-
Strangfeld, A
-
Gossec, L
-
visa fler...
-
Carmona, L
-
Mateus, EF
-
Schafer, M
-
Richez, C
-
Hachulla, E
-
Holmqvist, M
-
Scire, CA
-
Lorenz, HM
-
Voll, RE
-
Hasseli, R
-
Jayatilleke, A
-
Hsu, TYT
-
D'Silva, KM
-
Pimentel-Quiroz, ...
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del Mercado, MV
-
Shinjo, SK
-
Neto, ETD
-
da Rocha, LF
-
Montandon, ACDES
-
Pons-Estel, GJ
-
Ornella, S
-
Exeni, MED
-
Velozo, E
-
Jordan, P
-
Sirotich, E
-
Hausmann, JS
-
Liew, JW
-
Jacobsohn, L
-
Gore-Massy, M
-
Sufka, P
-
Grainger, R
-
Bhana, S
-
Wallace, Z
-
Robinson, PC
-
Yazdany, J
-
Machado, PM
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visa färre...
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Karolinska Institutet