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Träfflista för sökning "WFRF:(Poole J) srt2:(1998-1999)"

Sökning: WFRF:(Poole J) > (1998-1999)

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1.
  • Olsson, Martin L, et al. (författare)
  • The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein
  • 1998
  • Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048. ; 103:4, s. 1184-1191
  • Tidskriftsartikel (refereegranskat)abstract
    • The molecular basis of the three major alleles (Fy(a)/Fy(b)/Fy) of the Duffy (FY) blood group system has recently been established but the Fy(x) phenotype associated with weak expression of the Fy(b) and other FY antigens is poorly understood. In the Fy(x) genes of five unrelated British and Swedish donors with the Fy(a+b+weak) phenotype we found two missense mutations predicting amino acid changes Arg89Cys and Ala100Thr in the FY glycoprotein. The same mutations were found in two Fy(a-b+weak) samples from individuals of Swedish and Algerian origin. Their red blood cells showed a marked decrease in Fy(b), Fy3 and Fy6 expression measured by routine serology and flow cytometry. The rare FY genotypes Fy(x)Fy(x) and Fy(x)Fy were confirmed by family studies and DNA sequencing. Screening by allele-specific primer PCR (ASP-PCR) for these mutations among 100 Caucasian and 100 Black random blood donors indicated allele frequencies of 2.5% and 0% respectively. Ala100Thr alone was present in 33% of the Caucasians (but none of the Blacks) with no weakening of FY expression. A novel allele at the FY locus associated with the Fy(x) phenotype was studied. Mistyping of this weak Fy(b) antigen in clinical transfusion medicine may lead to delayed haemolytic transfusion reactions in immunized patients. A potential role for genomic typing is proposed.
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2.
  • Walker, R. P., et al. (författare)
  • European project to develop a UV/VUV free-electron laser facility on the ELETTRA storage ring
  • 1999
  • Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - 0168-9002. ; 429:1, s. 179-184
  • Tidskriftsartikel (refereegranskat)abstract
    • Sincrotrone Trieste, collaborating with various institutions, has recently begun a 3-year project to develop a UV/VUV free-electron laser on the ELETTRA storage ring. The main features and novel technical aspects of the project are described, including the design of the optical cavity and undulator, the electron beam characteristics and a first assessment of the predicted laser performance. Preliminary calculations suggest that the combined effects of a higher quality, higher energy electron beam, together with the use of a helical undulator, should significantly enhance FEL performance levels, as compared to present day values.
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