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- Taddei, C, et al.
(författare)
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Repositioning of the global epicentre of non-optimal cholesterol
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 582:7810, s. 73-
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Tidskriftsartikel (refereegranskat)abstract
- High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
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| 2. |
- Gahm, Gösta F., 1942-, et al.
(författare)
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Expanding shells around young clusters - S 171/Be 59
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 663
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Tidskriftsartikel (refereegranskat)abstract
- Context. Some HII regions that surround young stellar clusters are bordered by molecular shells that appear to expand at a rate inconsistent with our current model simulations. In this study we focus on the dynamics of Sharpless 171 (including NGC 7822), which surrounds the cluster Berkeley 59. Aims. We aim to compare the velocity pattern over the molecular shell with the mean radial velocity of the cluster for estimates of the expansion velocities of different shell structures, and to match the observed properties with model simulations. Methods. Optical spectra of 27 stars located in Berkeley 59 were collected at the Nordic Optical Telescope, and a number of molecular structures scattered over the entire region were mapped in 13CO(1- 0) at Onsala Space Observatory. Results. We obtained radial velocities and MK classes for the clustera's stars. At least four of the O stars are found to be spectroscopic binaries, in addition to one triplet system. From these data we obtain the mean radial velocity of the cluster. From the 13CO spectra we identify three shell structures, expanding relative to the cluster at moderate velocity (4 km s- 1), high velocity (12 km s- 1), and in between. The high-velocity cloudlets extend over a larger radius and are less massive than the low-velocity cloudlets. We performed a model simulation to understand the evolution of this complex. Conclusions. Our simulation of the Sharpless 171 complex and Berkeley 59 cluster demonstrates that the individual components can be explained as a shell driven by stellar winds from the massive cluster members. However, our relatively simple model produces a single component. Modelling of the propagation of shell fragments through a uniform interstellar medium demonstrates that dense cloudlets detached from the shell are decelerated less efficiently than the shell itself. They can reach greater distances and retain higher velocities than the shell.
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