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- Sangchooli, Arshiya, et al.
(författare)
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Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity
- 2024
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Ingår i: JAMA psychiatry. - : AMER MEDICAL ASSOC. - 2168-6238 .- 2168-622X.
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Forskningsöversikt (refereegranskat)abstract
- Importance In the last 25 years, functional magnetic resonance imaging drug cue reactivity (FDCR) studies have characterized some core aspects in the neurobiology of drug addiction. However, no FDCR-derived biomarkers have been approved for treatment development or clinical adoption. Traversing this translational gap requires a systematic assessment of the FDCR literature evidence, its heterogeneity, and an evaluation of possible clinical uses of FDCR-derived biomarkers. Objective To summarize the state of the field of FDCR, assess their potential for biomarker development, and outline a clear process for biomarker qualification to guide future research and validation efforts. Evidence Review The PubMed and Medline databases were searched for every original FDCR investigation published from database inception until December 2022. Collected data covered study design, participant characteristics, FDCR task design, and whether each study provided evidence that might potentially help develop susceptibility, diagnostic, response, prognostic, predictive, or severity biomarkers for 1 or more addictive disorders. Findings There were 415 FDCR studies published between 1998 and 2022. Most focused on nicotine (122 [29.6%]), alcohol (120 [29.2%]), or cocaine (46 [11.1%]), and most used visual cues (354 [85.3%]). Together, these studies recruited 19 311 participants, including 13 812 individuals with past or current substance use disorders. Most studies could potentially support biomarker development, including diagnostic (143 [32.7%]), treatment response (141 [32.3%]), severity (84 [19.2%]), prognostic (30 [6.9%]), predictive (25 [5.7%]), monitoring (12 [2.7%]), and susceptibility (2 [0.5%]) biomarkers. A total of 155 interventional studies used FDCR, mostly to investigate pharmacological (67 [43.2%]) or cognitive/behavioral (51 [32.9%]) interventions; 141 studies used FDCR as a response measure, of which 125 (88.7%) reported significant interventional FDCR alterations; and 25 studies used FDCR as an intervention outcome predictor, with 24 (96%) finding significant associations between FDCR markers and treatment outcomes. Conclusions and Relevance Based on this systematic review and the proposed biomarker development framework, there is a pathway for the development and regulatory qualification of FDCR-based biomarkers of addiction and recovery. Further validation could support the use of FDCR-derived measures, potentially accelerating treatment development and improving diagnostic, prognostic, and predictive clinical judgments.
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| 2. |
- Alimoradi, Zainab, et al.
(författare)
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Meta-analysis with systematic review to synthesize associations between oral health related quality of life and anxiety and depression
- 2024
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Ingår i: BDJ Open. - : Springer. - 2056-807X. ; 10:1
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Forskningsöversikt (refereegranskat)abstract
- ObjectivesThe present systematic review aimed to investigate how oral health related quality of life (OHQOL) associates with anxiety and depression. The study protocol was registered prospectively in the PROSPERO database (CRD42023389372).Materials and methodsStudies investigating associations between OHQOL and depression and/or anxiety were included. Fisher's Z scores were used to summarize associations between OHQOL and depression/anxiety. Funnel plots and Begg's Tests were used to assess publication bias. Meta-regression was conducted to examine potential moderator effects in the associations. Academic databases including the ISI Web of Knowledge, Scopus, ProQuest and PubMed were systematically searched. The quality of included studies was checked with the Newcastle Ottawa Scale (NOS).ResultsAll 15 included studies were cross-sectional (14,419 participants from nine countries; mean age=43.74 years). The pooled estimates showed weak associations between OHQOL and depression (Fisher's z-score of 0.26 [95% CI = 0.17, 0.35; I2 = 96.2%; tau 2 = 0.03]) and anxiety (Fisher's z-score of 0.22 [95% CI = 0.001, 0.43; I2 = 97.9%; tau 2 = 0.06]). No severe problems in methodology quality, publication biases, or moderator effects were observed.ConclusionBoth depression and anxiety were weakly associated with individuals' OHQOL. Although the synthesized associations were not strong, they were significant, indicating that depression and anxiety are potential factors influencing individuals' OHQOL.
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| 3. |
- Chen, Chao-Ying, et al.
(författare)
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Problematic Use of Internet Associates with Poor Quality of Life via Psychological Distress in Invididuals with ADHD
- 2024
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Ingår i: Psychology Research and Behavior Management. - : Dove Medical Press. - 1179-1578. ; 17, s. 443-455
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Tidskriftsartikel (refereegranskat)abstract
- Background: Problematic use of internet (PUI) may have negative impacts on psychological distress and quality of life (QoL). This situation might be more profound in people with attention-deficit/hyperactivity disorder (ADHD) due to poorer behavioral control and regulatory capacity. However, there is little evidence regarding mediated effects in the associations between PUI, psychological distress, and QoL in people with ADHD. Aims: To investigate mediating effects of psychological distress in the associations of problematic smartphone use (PSPU), problematic use of social media (PUSM), and problematic gaming (PG) with QoL in individuals with ADHD. Methods and Procedures: PUI behaviors of participants with ADHD (n = 99) were assessed using the Smartphone ApplicationBased Addiction Scale, Bergen Social Media Addiction Scale, and Internet Gaming Disorder-Short Form. Psychological distress was assessed using the Depression, Anxiety, Stress Scale and QoL using the Kid-KINDL. Outcomes and Results: Psychological distress mediated the associations between PUI and different domains of QoL, except for selfesteem QoL. There were also positively direct effects between PG and physical QoL, PUSM and friends' QoL, and PSPU and physical QoL. Conclusions and Implications: PUI may associate with poor QoL in people with ADHD via psychological distress. Programs on reducing PUI for people with ADHD are needed.
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| 4. |
- Pakpour, Amir H., et al.
(författare)
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The YouTube Addiction Scale : Psychometric Evidence for a New Instrument Developed Based on the Component Model of Addiction
- 2024
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Ingår i: International Journal of Mental Health and Addiction. - : Springer. - 1557-1874 .- 1557-1882.
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Tidskriftsartikel (refereegranskat)abstract
- Technological advances have created the environment for Internet addiction (IA). A specific form of IA is social media addiction. Moreover, social media addiction may be further classified into general or specific social media addiction, with YouTube addiction among the latter because YouTube is viewed as a video streaming application. The present study aimed to design an instrument assessing YouTube addiction (named as the YouTube Addiction Scale, YAS) for psychometric testing. Guided by the component model of addiction, the YAS included six items corresponding to salience, mood modification, tolerance, withdrawal, conflict, and relapse. Through an online survey, the first sample (N = 530; 50.6% female) completed the YAS together with other measures assessing general social media addiction, psychological distress, and demographic information. Afterward, a second sample (N = 512; 45.5% female) completed the YAS in another period of time. The YAS was found to be unidimensional with strong factor loadings in both exploratory factor analysis (the first sample) and confirmatory factor analysis (the second sample). Internal consistency of the YAS was acceptable for both samples. Using the first sample's data, Rasch models suggested that the six items in the YAS all fit well in the embedded construct of YouTube addiction. No differential item functioning was displayed for all YAS items across age, gender, and weekly time spent using YouTube. Network analysis results showed that the YAS items grouped together and had a clear distance from all items assessing general social media addiction. In addition, participants with higher levels of YouTube addiction had significantly greater general social media addiction, psychological distress, and time spent on YouTube. The YAS has promising psychometric properties for healthcare providers and researchers to assess individuals' YouTube addiction levels. Future studies should examine the extent to which with the use of YAS, healthcare providers may monitor the severity of individuals' YouTube addiction and provide early intervention, if needed.
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