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Effect of a Smoking...
Effect of a Smoking and Alcohol Cessation Intervention Initiated Shortly Before Radical Cystectomy—the STOP-OP Study : A Randomised Clinical Trial
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- Lauridsen, Susanne Vahr (författare)
- Copenhagen University Hospital,Frederiksberg Hospital
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- Thomsen, Thordis (författare)
- University of Copenhagen,Gentofte Hospital
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- Jensen, Jørgen Bjerggaard (författare)
- Aarhus University Hospital
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- Kallemose, Thomas (författare)
- Copenhagen University Hospital
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- Schmidt Behrend, Monika (författare)
- Gentofte Hospital
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- Steffensen, Kirsten (författare)
- Aalborg University Hospital
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- Poulsen, Alicia Martin (författare)
- Copenhagen University Hospital
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- Jacobsen, André (författare)
- Copenhagen University Hospital,Gentofte Hospital
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- Walther, Lisa (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Isaksson, Anders (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Thind, Peter (författare)
- Copenhagen University Hospital
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- Tønnesen, Hanne (författare)
- Lund University,Lunds universitet,Kliniskt Centrum för Hälsofrämjande Vård,Forskargrupper vid Lunds universitet,Clinical Health Promotion Centre,Lund University Research Groups,WHO-CC,Frederiksberg Hospital
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: European Urology Focus. - : Elsevier BV. - 2405-4569. ; 8:6, s. 1650-1658
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.eu-focus....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Evidence concerning the reduction of postoperative complications due to smoking and alcohol drinking in patients undergoing radical cystectomy is incomplete. Objective: To evaluate the efficacy of a 6-wk smoking and/or alcohol cessation intervention, initiated shortly before surgery and continued until 4 wk after, in reducing complications. Design, setting, and participants: Between 2014 and 2018, we enrolled 104 patients with high-risk bladder cancer who were daily smokers or consuming at least 3 units of alcohol daily in a multicentre randomised clinical trial. Intervention: Patients were randomised to a 6-wk intensive smoking and/or alcohol cessation intervention or treatment as usual. Outcome measurements and statistical analysis: The primary endpoint was the number of patients developing any postoperative complication, or death, within 30 d after surgery. The secondary endpoints were successful quitters, health-related quality of life, length of stay, time back to habitual activity, and mortality. An intention-to-treat analysis was applied to evaluate treatment effect. Results and limitations: There were some differences in baseline demographic and lifestyle characteristics. Postoperatively, 64% in the intervention group versus 70% in the control group (risk ratio [RR] 0.91, confidence interval [CI] 0.68–1.21, p = 0.51) developed complications. Significantly fewer patients developed three or more complications after 30 d (RR 0.39; CI 0.18–0.84, p = 0.01). The rates of successful quitting were 51% in the intervention group and 27% in the control group (RR 2, CI 1.14–3.51, p = 0.01). The external validity of this trial may be limited because 53% of eligible patients refused participation. Conclusions: Despite a significant effect on the quit rate at completion of the intervention, this multimodal prehabilitation did not show a significant difference regarding our primary outcome postoperative complications. Patient summary: A 6-wk smoking and alcohol cessation intervention in relation to bladder cancer surgery did not reduce postoperative complications, but it was effective in supporting people to quit in the short term.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Alcohol drinking
- Bladder cancer
- Postoperative complications
- Radical cystectomy
- Smoking
- Surgery
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Lauridsen, Susan ...
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Thomsen, Thordis
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Jensen, Jørgen B ...
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Kallemose, Thoma ...
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Schmidt Behrend, ...
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Steffensen, Kirs ...
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Poulsen, Alicia ...
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Jacobsen, André
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Walther, Lisa
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Isaksson, Anders
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Thind, Peter
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Tønnesen, Hanne
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