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Non-targeted urine ...
Non-targeted urine metabolomics and associations with prevalent and incident type 2 diabetes
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
- Uppsala universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Örebro Univ, Sch Med Sci, Örebro, Sweden
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- Broeckling, Corey D. (författare)
- Analytical Resources Core: Bioanalysis and Omics Center, Colorado State University, Fort Collins, CO, USA,Colorado State Univ, Analyt Resources Core Bioanal & Omics Ctr, Ft Collins, CO 80523 USA.
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- Ganna, Andrea (författare)
- Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA,Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.
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- Prenni, Jessica E. (författare)
- Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO, USA,Colorado State Univ, Dept Hort & Landscape Architecture, Ft Collins, CO 80523 USA.
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- Sundström, Johan, 1971- (författare)
- Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.
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- Berne, Christian (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi
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- Ingelsson, Erik, 1975- (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
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- Fall, Tove, 1979- (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.;Karolinska Inst, Family Med & Primary Care Unit, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden.
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- Nowak, Christoph (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-10-05
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://du.diva-port... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two community cohorts of 1,424 adults were analyzed by ultra-performance liquid chromatography/mass spectrometry (UPLC-MS). In a discovery/replication design, three out of 62 annotated metabolites were associated with prevalent T2D, notably lower urine levels of 3-hydroxyundecanoyl-carnitine. In participants without diabetes at baseline, LASSO regression in the training set selected six metabolites that improved prediction of T2D beyond established risk factors risk over up to 12 years' follow-up in the test sample, from C-statistic 0.866 to 0.892. Our results in one of the largest non-targeted urinary metabolomics study to date demonstrate the role of the urine metabolome in identifying at-risk persons for T2D and suggest urine 3-hydroxyundecanoyl-carnitine as a biomarker candidate.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- Av författaren/redakt...
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Salihovic, Samir ...
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Broeckling, Core ...
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Ganna, Andrea
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Prenni, Jessica ...
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Sundström, Johan ...
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Berne, Christian
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Lind, Lars
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Ingelsson, Erik, ...
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Fall, Tove, 1979 ...
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Ärnlöv, Johan, 1 ...
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Nowak, Christoph
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Scientific Repor ...
- Av lärosätet
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Örebro universitet
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Högskolan Dalarna
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Uppsala universitet
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Karolinska Institutet