| 1. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 2. |
- Sodergren, Erica, et al.
(författare)
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The genome of the sea urchin Strongylocentrotus purpuratus.
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 314:5801, s. 941-52
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Tidskriftsartikel (refereegranskat)abstract
- We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
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| 3. |
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| 4. |
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| 5. |
- De Vin, Leo, et al.
(författare)
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Information Fusion : What can the manufacturing sector learn from the defence industry?
- 2005
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Ingår i: IMC 22: Challenges Facing Manufacturing. - Dublin : Institute of Technology, Tallaght. - 9780955121807 ; , s. 363-371
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Konferensbidrag (refereegranskat)abstract
- This paper discusses information fusion including its nature as well as some models for information fusion. Research on information fusion is dominated by defence applications and therefore, most models to a certain extent are defence specific; it is explained how these can be made more generic by adapting them. It is explained how the manufacturing sector can benefit from information fusion research; some analogies between issues in manufacturing and issues in military applications are given. A specific area in which the manufacturing sector can benefit from research on information fusion is the area of virtual manufacturing. Many issues related to decision support through modelling, simulation and synthetic environments are identical for manufacturing and defence applications. A particular area of interest for the future will be verification, validation and accreditation of modelling and simulation components for synthetic environments with various involved parties.
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| 6. |
- De Vin, Leo, et al.
(författare)
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Information fusion for decision support in manufacturing : studies from the defense sector
- 2008
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Ingår i: The International Journal of Advanced Manufacturing Technology. - : Springer. - 0268-3768 .- 1433-3015. ; 35:9-10, s. 908-915
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Information fusion, the synergistic combination of information from multiple sources, is an established research area within the defense sector. In manufacturing however, it is less well-established, with the exception of sensor/data fusion for automatic decision making. The paper briefly discusses some military specific models and methods for information fusion; analogies with manufacturing as well as a more generalized terminology are presented. “Manufacturing” is an application scenario within a Swedish information fusion research program that studies information fusion from databases, sensors and simulations with (currently) a focus on support for human decision making. An area of particular interest is that of advanced applications of virtual manufacturing such as synthetic environments, a form of hardware in the loop simulation that can deliver services such as service and maintenance at remote locations. In this area, the manufacturing industry can benefit from ongoing work in the defense sector related to verification, validation and accreditation of simulation models.
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| 7. |
- Hallac, B. B., et al.
(författare)
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Biomass Characterization of Buddleja davidii: A Potential Feedstock for Biofuel Production
- 2009
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Ingår i: Journal of Agricultural and Food Chemistry. - : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 57:4, s. 1275-1281
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Tidskriftsartikel (refereegranskat)abstract
- A compositional analysis was performed on Buddleja davidii to determine its general biomass characteristics and provide detailed analysis of the chemical structures of its cellulose and lignin using NMR. B. davidii is a new potential lignocellulosic bioresource for producing bioethanol because it has several attractive agroenergy features. The biomass composition of B. davidii is 30% lignin, 35% cellulose, and 34% hemicellulose. Solid-state CP/MAS C-13 NMR showed that 33% of the cellulose is para-crystalline and 41% is at inaccessible surfaces. Both quantitative C-13 and P-31 NMR were used to examine the structure of lignin. The lignin was determined to be guaiacyl and syringyl with an h:g:s ratio of 0:81:19.
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| 8. |
- Zeisberg, Elisabeth M., et al.
(författare)
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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
- 2007
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 13:8, s. 952-961
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Tidskriftsartikel (refereegranskat)abstract
- Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies are not currently available. Here we show that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of the atrioventricular cushion in the embryonic heart. Transforming growth factor-beta 1 (TGF-beta 1) induced endothelial cells to undergo EndMT, whereas bone morphogenic protein 7 (BMP-7) preserved the endothelial phenotype. The systemic administration of recombinant human BMP-7 (rhBMP-7) significantly inhibited EndMT and the progression of cardiac fibrosis in mouse models of pressure overload and chronic allograft rejection. Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis.
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