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Träfflista för sökning "WFRF:(Purdie M) srt2:(2006-2009)"

Sökning: WFRF:(Purdie M) > (2006-2009)

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  • Blauw, A. N., et al. (författare)
  • The use of fuzzy logic for data analysis and modelling of European harmful algal blooms: results of the HABES project
  • 2006
  • Ingår i: African Journal of Marine Science. - 1814-232X. ; 28:2, s. 365-369
  • Tidskriftsartikel (refereegranskat)abstract
    • Fuzzy logic was applied to model blooms of Nodularia spumigena, Dinophysis spp., Alexandrium minutum, Karenia mikimotoi and Phaeocystis globosa at various European sites as part of the Harmful Algal Blooms Expert System (HABES) project. This modelling approach was useful in performing integrated analyses of interacting physical and biological factors involved in HABs. A basic knowledge of HAB formation and sufficient data are a prerequisite for successful bloom prediction.
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3.
  • Shah, R, et al. (författare)
  • The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer.
  • 2009
  • Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 100:10, s. 1687-96
  • Tidskriftsartikel (refereegranskat)abstract
    • Expression of P3H2 (Leprel1) and P3H3 (Leprel2) but not P3H1 (Leprecan) is down-regulated in breast cancer by aberrant CpG methylation in the 5' regulatory sequences of each gene. Methylation of P3H2 appears specific to breast cancer as no methylation was detected in a range of cell lines from other epithelial cancers or from primary brain tumours or malignant melanoma. Methylation in P3H2, but not P3H3, was strongly associated with oestrogen-receptor-positive breast cancers, whereas methylation in P3H3 was associated with higher tumour grade and Nottingham Prognostic Index. Ectopic expression of P3H2 and P3H3 in cell lines with silencing of the endogenous gene results in suppression of colony growth. This is the first demonstration of epigenetic inactivation of prolyl hydroxylases in human cancer, implying that this gene family represents a novel class of tumour suppressors. The restriction of silencing in P3H2 to breast carcinomas, and its association with oestrogen-receptor-positive cases, suggests that P3H2 may be a breast-cancer-specific tumour suppressor.
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