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- Wright, G. S., et al.
(författare)
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The Mid-Infrared Instrument for the James Webb Space Telescope, II: Design and Build
- 2015
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Ingår i: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 127:953, s. 595-611
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Tidskriftsartikel (refereegranskat)abstract
- The Mid-InfraRed Instrument (MIRI) on the James Webb Space Telescope (JWST) provides measurements over the wavelength range 5 to 28: 5 mu m. MIRI has, within a single "package," four key scientific functions: photometric imaging, coronagraphy, single-source low-spectral resolving power (R similar to 100) spectroscopy, and medium-resolving power (R similar to 1500 to 3500) integral field spectroscopy. An associated cooler system maintains MIRI at its operating temperature of
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- Álvarez-Márquez, J., et al.
(författare)
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Investigating the physical properties of galaxies in the Epoch of Reionization with MIRI/JWST spectroscopy
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 629
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Tidskriftsartikel (refereegranskat)abstract
- The James Webb Space Telescope (JWST) will provide deep imaging and spectroscopy for sources at redshifts above 6, covering the entire Epoch of Reionization (EoR, 6 < z < 10), and enabling the detailed exploration of the nature of the different sources during the first 1 Gyr of the history of the Universe. The Medium Resolution Spectrograph (MRS) of the mid-IR Instrument (MIRI) will be the only instrument on board JWST able to observe the brightest optical emission lines H alpha and [OII]0.5007 mu m at redshifts above 7 and 9, respectively, providing key insights into the physical properties of sources during the early phases of the EoR. This paper presents a study of the Ha fluxes predicted by state-of-the-art FIRSTLIGHT cosmological simulations for galaxies at redshifts of 6.5-10.5, and its detectability with MIRI. Deep (40 ks) spectroscopic integrations with MRS will be able to detect (signal-to-noise ratio > 5) EoR sources at redshifts above 7 with intrinsic star formation rates (SFR) of more than 2M(circle dot) yr(-1), and stellar masses above 4-9 x 10(7) M-circle dot. These limits cover the upper end of the SFR and stellar mass distribution at those redshifts, representing similar to 6% and similar to 1% of the predicted FIRSTLIGHT population at the 6.5-7.5 and 7.5-8.5 redshift ranges, respectively. In addition, the paper presents realistic MRS simulated observations of the expected rest-frame optical and near-infrared spectra for some spectroscopically confirmed EoR sources recently detected by ALMA as [OIII]88 mu m emitters. The MRS simulated spectra cover a wide range of low metallicities from about 0.2-0.02Z(circle dot) and different [OIII]88 mu m/[OIII]0.5007 mu m line ratios. The simulated 10 ks MRS spectra show S/N in the range of 5-90 for H beta, [OIII]0.4959,0.5007 mu m, H alpha and HeI1.083 mu m emission lines of the currently highest spectroscopically confirmed EoR (lensed) source MACS1149-JD1 at a redshift of 9.11, independent of metallicity. In addition, deep 40 ksec simulated spectra of the luminous merger candidate B14-65666 at 7.15 shows the MRS capabilities of detecting, or putting strong upper limits on, the weak [NII]0.6584 mu m. [SII]0.6717,0.6731 mu m, and [SIII] 0.9069,0.9532 mu m emission lines. These observations will provide the opportunity of deriving accurate metallicities in bright EoR sources using the full range of rest-frame optical emission lines up to 1 mu m. In summary, MRS will enable the detailed study of key physical properties such as internal extinction, instantaneous star formation, hardness of the ionizing continuum, and metallicity in bright (intrinsic or lensed) EoR sources.
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- Eriksson, Anna-Lena, 1971, et al.
(författare)
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Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.
- 2018
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 103:3, s. 991-1004
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Tidskriftsartikel (refereegranskat)abstract
- Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability.To investigate the genetic regulation of serum E2 and E1 in men.Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts.Genetic determinants of serum E2 and E1 levels.Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent signals were found on the X chromosome; FAMily with sequence similarity 9, member B (FAM9B), rs5934505 (P = 3.4 × 10-8) and Xq27.3, rs5951794 (P = 3.1 × 10-10). E1 signals were found in CYP19A1 (rs2899472, P = 5.5 × 10-23), in Tripartite motif containing 4 (TRIM4; rs17277546, P = 5.8 × 10-14), and CYP11B1/B2 (rs10093796, P = 1.2 × 10-8). E2 signals in CYP19A1 and FAM9B were associated with bone mineral density (BMD). Mendelian randomization analysis suggested a causal effect of serum E2 on BMD in men. A 1 pg/mL genetically increased E2 was associated with a 0.048 standard deviation increase in lumbar spine BMD (P = 2.8 × 10-12). In men and women combined, CYP19A1 alleles associated with higher E2 levels were associated with lower degrees of insulin resistance.Our findings confirm that CYP19A1 is an important genetic regulator of E2 and E1 levels and strengthen the causal importance of E2 for bone health in men. We also report two independent loci on the X-chromosome for E2, and one locus each in TRIM4 and CYP11B1/B2, for E1.
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- Zhang, Haofei, et al.
(författare)
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Monoterpenes are the largest source of summertime organic aerosol in the southeastern United States
- 2018
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:9, s. 2038-2043
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Tidskriftsartikel (refereegranskat)abstract
- The chemical complexity of atmospheric organic aerosol (OA) has caused substantial uncertainties in understanding its origins and environmental impacts. Here, we provide constraints on OA origins through compositional characterization with molecular-level details. Our results suggest that secondary OA (SOA) from monoterpene oxidation accounts for approximately half of summertime fine OA in Centreville, AL, a forested area in the southeastern United States influenced by anthropogenic pollution. We find that different chemical processes involving nitrogen oxides, during days and nights, play a central role in determining the mass of monoterpene SOA produced. These findings elucidate the strong anthropogenic–biogenic interaction affecting ambient aerosol in the southeastern United States and point out the importance of reducing anthropogenic emissions, especially under a changing climate, where biogenic emissions will likely keep increasing.
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