| 1. |
- Ablikim, M., et al.
(författare)
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Measurements of (XcJ)-> K+K-K+K- decays
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 642:3, s. 197-202
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Tidskriftsartikel (refereegranskat)abstract
- Using 14M psi(2S) events taken with the BESII detector, chi(cJ) -> 2(K+K-) decays are studied. For the four-kaon final state, the branching fractions are B(chi(c0,1,2) ->.2(K+K-)) = (3.48 +/- 0.23 +/- 0.47) x 10(-3), (0.70 +/- 0.13 +/- 0.10) x 10(-3), and (2.17 +/- 0.20 +/- 0.31) x 10(-3). For the phi K+K- final state, the branching fractions, which are measured for the first time, are B(chi(c0,1,2) -> phi K+K-) = (1.03 +/- 0.22 +/- 0.15) x 10(-3), (0.46 +/- 0.16 +/- 0.06) x 10(-3), and (1.67 +/- 0.26 +/- 0.24) x 10(-4). For the phi phi final state, B(chi(c0,2) -> phi phi) = (0.94 +/- 0.21 +/- 0.13) x 10(-3) and (1.70 +/- 0.30 +/- 0.25) x 10(-3).
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| 2. |
- Armesto, N., et al.
(författare)
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Heavy-ion collisions at the LHC-Last call for predictions
- 2008
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 35:5, s. 054001-
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Forskningsöversikt (refereegranskat)abstract
- This writeup is a compilation of the predictions for the forthcoming Heavy Ion Program at the Large Hadron Collider, as presented at the CERN Theory Institute 'Heavy Ion Collisions at the LHC - Last Call for Predictions', held from 14th May to 10th June 2007.
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| 3. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 4. |
- Zeggini, Eleftheria, et al.
(författare)
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:5, s. 638-645
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
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| 5. |
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| 6. |
- Qin, Jian, et al.
(författare)
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A high-performance magnetic resonance imaging T2 contrast agent
- 2007
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 19:14, s. 1874-1878
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Tidskriftsartikel (refereegranskat)abstract
- A high-performance magnetic resonance imaging T-2 contrast agent has been prepared via phase transfer of hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) to an aqueous solution by using Pluronic F127 copolymers. As seen in the figure, a hierarchical structure of the surface coating is formed and proven to be a crucial characteristic to enhance not only water dispersibility, but also the efficacy as a T-2 contrast agent.
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| 7. |
- Vallhov, H., et al.
(författare)
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The effect of gold nanoparticles on dendritic cells
- 2006
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Ingår i: 2006 NSTI Nanotechnology Conference and Trade Show. - 0976798565 - 9780976798569
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Konferensbidrag (refereegranskat)abstract
- Gold is recognized as one of the most biocompatible and stable materials, and has been used for many years as a medical agent, among others in the form of salt for the treatment of rheumatoid arthritis [1]. More recent biological applications have been focusing on using gold nanoparticles for drug and gene delivery [2], or as a photothermal agent causing highly localized heating applicable in cancer therapy [3]. There is however very little information available concerning what influence such particles have on the immune system, e.g. on dendritic cells (DCs). DCs are present throughout the human body but are particularly localized at antigen-exposed sites, such as the skin. They are the most efficient type of antigen presenting cells having a capacity both to initiate primary and secondary immune responses, by expressing cytokines, MHC and co-stimulatory molecules such as CD80, CD83 and CD86 [4-5]. DCs decide whether an immune response should be initiated and are able to affect the development of T-helper cells into Treg-, Th1- or Th2-cells depending on their cytokines produced and their expression of co-stimulatory molecules [6]. We addressed the question whether spherical gold nanoparticles of 6 nm in diameter affect DCs, looking at morphology, viability, expression of cytokines and of co-stimulatory and antigen presenting molecules. This was assessed by using human monocyte derived DCs (myeloid DCs) and peripheral blood mononuclear cells from healthy blood donors together with gold nanoparticles [7], and various techniques including light microscopy, flow cytometry and ELISpot. After having overcome aggregation problems of gold nanoparticles by stabilizing with human serum albumin (HSA) and developed methods to produce nanoparticles with low lipopolysaccharide (LPS) contamination, experiments revealed that both morphology and viability were not affected by the gold nanoparticles. The expression of CD80, CD83, CD86 and MHC class II was only to a minor degree up-regulated after 6 and 24 h, and CD40 and MHC class I was not affected, which indicates biocompatibility of gold nanoparticles. This is further supported by low or no expression of the cytokines IL-10, IL-12 and IFN-alpha. HSA by itself did not have an effect on the DCs. In conclusion, gold nanoparticles of 6 nm in diameter are highly unlikely to initiate a danger signal to the immune system through the dendritic cells, and have therefore the potential to be used as inert carriers in biomedical applications.
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| 8. |
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| 9. |
- Chen, Daru, et al.
(författare)
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Switchable dual-wavelength Raman erbium-doped fibre laser
- 2006
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Ingår i: Electronics Letters. - : Institution of Engineering and Technology (IET). - 0013-5194 .- 1350-911X. ; 42:4, s. 202-204
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Tidskriftsartikel (refereegranskat)abstract
- A fibre Bragg grating feedback fibre laser with both Raman and erbium-doped fibre pumps is proposed. Dual-wavelength switching is achieved by controlling the power of the Raman pump. The characteristics of the dual-wavelength switching are studied experimentally, and the mechanism is explained physically.
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| 10. |
- Du, Xueli, et al.
(författare)
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Study of rare-earth oxide sintering aid systems for AlN ceramics
- 2007
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Ingår i: Materials Science & Engineering. - : Elsevier BV. - 0921-5093 .- 1873-4936. ; 460-461, s. 471-474
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Tidskriftsartikel (refereegranskat)abstract
- In the present work, effects of Y2O3 and Dy2O3 sintering aid systems on density and thermal conductivity of AlN ceramics sintered at low temperature were investigated. The AlN powder synthesized by self-propagating high-temperature synthesis (SHS) was mixed individually with six different sintering aids, which were Y2O3, Dy2O3, CaF2–Y2O3, CaF2–Dy2O3, CaF2–Li2CO3–Y2O3 and CaF2–Li2CO3–Dy2O3, and then fabricated by employing press forming technique. The specimens were sintered at 1650 °C in nitrogen atmosphere at atmospheric pressure for 4 h. X-ray diffraction (XRD) was used to identify the secondary phases. The microstructure of the specimen was observed by scanning electron microscopy (SEM). The thermal diffusivity at room temperature was measured by a laser flash technique. Density of sintered specimen was measured by Archimedes displacement method. The result reveals that the density and thermal conductivity of AlN ceramics sintered with one component sintering aids were lower than those of sintered with multiple components sintering aids. The thermal conductivity of AlN ceramics sintered with CaF2–Li2CO3–Y2O3 and CaF2–Dy2O3 were 141 W m−1 K−1 and 142 W m−1 K−1, which were higher than that of any others.
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