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Träfflista för sökning "WFRF:(Rönnberg Sarah K.) srt2:(2010-2014)"

Sökning: WFRF:(Rönnberg Sarah K.) > (2010-2014)

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1.
  • Karlsson, Elinor K, et al. (författare)
  • Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
  • 2013
  • Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X .- 1474-7596. ; 14:12
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible.RESULTS: Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors. The top germline candidate variant is found at a >90% frequency in Rottweilers and Irish wolfhounds, and alters an evolutionarily constrained element that we show has strong enhancer activity in human osteosarcoma cells. In all three breeds, osteosarcoma-associated loci and regions of reduced heterozygosity are enriched for genes in pathways connected to bone differentiation and growth. Several pathways, including one of genes regulated by miR124, are also enriched for somatic copy-number changes in tumors.CONCLUSIONS: Mapping a complex cancer in multiple dog breeds reveals a polygenic spectrum of germline risk factors pointing to specific pathways as drivers of disease.
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2.
  • Rönnberg, Sarah K., et al. (författare)
  • Harmonic emission before and after changing to LED and CFL - Part I: Laboratory measurements for a domestic customer
  • 2010
  • Ingår i: 14th International Conference on Harmonics and Quality of Power (ICHQP). - Piscataway, NJ : IEEE Communications Society. - 9781424472444 - 9781424472451
  • Konferensbidrag (refereegranskat)abstract
    • This paper presents an investigation after the impact on a number of power-quality parameters due to the change from incandescent lamps to energy saving lamps like CFL and LED. The measurements were conducted in a full-scale laboratory model with ordinary household equipment connected, thus simulating an ordinary domestic customer. Incandescent lamps have been replaced in stages by CFL and LED lamps. The CFL's and LED lamps will contribute to an increase in current distortion but the amplitude of the harmonics is quite low so the change of lighting will only have a minor effect on the total current harmonic distortion. It is also shown that the (total) power factor is not a good indicator to compare the impact of different loads on the system.
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