| 1. |
- Dahlhoff, Maik, et al.
(författare)
-
A new mouse model for studying EGFR-dependent gastric polyps.
- 2012
-
Ingår i: Biochimica et biophysica acta. - : Elsevier BV. - 0006-3002. ; 1822:8, s. 1293-1299
-
Tidskriftsartikel (refereegranskat)abstract
- Hyperactivation of the epidermal growth factor receptor (EGFR) in gastric cells due to excess of its ligand transforming growth factor-α (TGFA) is associated with hyperplastic lesions in Ménétrier's disease patients and in transgenic mice. Other EGFR ligands, however, have never been associated with stomach diseases. Here, we report that overexpression of the EGFR ligand betacellulin (BTC) results in a severe, age-dependent hyperplasia of foveolar epithelium. The stomach weight of affected mice reached up to 3g representing more than 10% of total body weight. The preexisting corpus mucosa was severely depleted, and both parietal and chief cells were replaced by proliferating foveolar epithelium. The lesions were more severe in male as compared to female transgenic mice, and partially regressed in the former after castration-mediated androgen removal. The gastric hyperplasia fully disappeared when BTC-tg mice were crossed into the Egfr(Wa5) background expressing a dominant-negative EGFR, indicating that the phenotype is EGFR-dependent. This is, to our knowledge, the first report of hyperplastic gastric lesions due to the overexpression of an EGFR ligand other than TGFA. BTC-tg mice are therefore a new, promising model for studying EGFR-dependent gastric polyps.
|
|
| 2. |
- Sinaei, Sima, et al.
(författare)
-
Ada in real-time embedded system
- 2013
-
Ingår i: Research Journal of Applied Sciences, Engineering and Technology. - : Maxwell Science Publications. - 2040-7459 .- 2040-7467. ; 5:14, s. 3803-3809
-
Tidskriftsartikel (refereegranskat)abstract
- Ada has an important role in the real-time/embedded/safety-critical areas. It is the only ISO-standard, object-oriented, concurrent, real-time programming language. Ada is used as a usual language for application areas such as defense embedded systems that reliability and efficiency are very essential. One of the main Ada’s characteristics in compare with other programming languages is that, Ada was developed from the ground up with capabilities that provide real-time requirements. In this study it will be shown why Ada is used as the new standard for real-time programming languages and basic characteristics of real-time programming system in general and how they are addressed in Ada will be explained.
|
|
