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Träfflista för sökning "WFRF:(Radenkovic D) srt2:(2010-2014)"

Search: WFRF:(Radenkovic D) > (2010-2014)

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1.	Besselink, M, et al. (author) IAP/APA evidence-based guidelines for the management of acute pancreatitis 2013 In: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. - : Elsevier BV. - 1424-3911. ; 13:44 Suppl 2, s. E1-E15 Journal article (peer-reviewed)
2.	Popovic, S., et al. (author) Endoplasmic reticulum stress associated with caspases-4 and-2 mediates korbazol-induced B-chronic lymphocytic leukemia cell apoptosis 2010 In: Journal of Buon. - 1107-0625. ; 15:4, s. 783-790 Journal article (peer-reviewed)abstract Purpose: B-cell chronic lymphocytic leukemia (B-CLL) is an incurable disease that rapidly develops drug resistance. Therefore there is a need for identifying new agents that will improve the therapeutic outcome. Korbazol is a natural product known to exert cytotoxic effect on the in vitro survival of leukemic cells. The aim of this study was to investigate the mechanism of korbazol-induced apoptosis in B-CLL leukemic cells. Methods: Peripheral blood mononuclear cells from 10 B-CLL patients were used for assessing the effect of caspase inhibitors and chelator of intracellular Ca2+ Results: Cell death rate induced by the tested compound was decreased with the caspase-3 inhibitor Ac-DEVD-CHO, and the inhibitors of caspase-2 (Z-VDVAD-FMK) and -4 (ZYVAD-FMK), but not with the caspase-9 inhibitor z-LEHD-FMK and caspase-8 inhibitor z-IETD-FMK No significant release of cytochrome C (cyt C) from mitochondria to the cytosol of B-CLL cells treated with korbazol was observed. Moreover, chelating of intracellular Ca2+ with BAPTA-AM almost completely abolished the cytotoxic effect of korbazol. Conclusion: Engagement of caspases-2 and -4 and mobilization of intracellular Ca2+ indicate involvement of endoplasmic reticulum (ER) stress in apoptosis induced by korbazol.
3.	Main, H, et al. (author) Cell surface antigen profiling using a novel type of antibody array immobilised to plasma ion-implanted polycarbonate 2014 In: Cellular and molecular life sciences : CMLS. - : Springer Science and Business Media LLC. - 1420-9071 .- 1420-682X. ; 71:19, s. 3841-3857 Journal article (peer-reviewed)

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Liu, X (1); Wang, C. (1); Zhao, Y. (1); Johnson, C. (1); Tanaka, M. (1); Sarr, M (1); show more...; Singh, V. (1); Lendahl, U (1); Buchler, M (1); Radenkovic, D (1); Werner, J (1); Seifert, H. (1); Mitrovic, M (1); Bakker, O (1); Anderson, R (1); Levy, P (1); Andren-Sandberg, A (1); Morgan, D. (1); Bruno, M. (1); Bassi, C. (1); Dervenis, C. (1); Hartwig, W (1); Connor, S (1); de Waele, J. (1); Sutton, R (1); van Goor, H (1); Main, H (1); Baron, T (1); Petrov, M. (1); Wu, B (1); Besselink, M (1); van Santvoort, H (1); Freeman, M (1); Gardner, T (1); Mayerle, J (1); Vege, SS (1); Banks, P (1); Mckay, C (1); Fernandez-Del Castil ... (1); French, J (1); Gooszen, H (1); Takada, T (1); Windsor, J (1); Saluja, A (1); Liddle, R (1); Papachristou, G (1); Runzi, M (1); Bollen, T (1); Mortele, K (1); Mittal, A (1); show less...

University: Karolinska Institutet (2); Lund University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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