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Ginsenoside Rg3 Red...
Ginsenoside Rg3 Reduces the Toxicity of Graphene Oxide Used for pH-Responsive Delivery of Doxorubicin to Liver and Breast Cancer Cells
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- Rahimi, Shadi, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- van Leeuwen, Daniel, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Roshanzamir, Fariba, 1986 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Pandit, Santosh, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Shi, Lei, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Sasanian, Nima, 1993 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,BioInnovation Institute (BII)
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- Esbjörner Winters, Elin, 1978 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mijakovic, Ivan, 1975 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Danmarks Tekniske Universitet,Technical University of Denmark
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(creator_code:org_t)
- 2023-01-24
- 2023
- Engelska.
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Ingår i: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 15:2
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Doxorubicin (DOX) is extensively used in chemotherapy, but it has serious side effects and is inefficient against some cancers, e.g., hepatocarcinoma. To ameliorate the delivery of DOX and reduce its side effects, we designed a pH-responsive delivery system based on graphene oxide (GO) that is capable of a targeted drug release in the acidic tumor microenvironment. GO itself disrupted glutathione biosynthesis and induced reactive oxygen species (ROS) accumulation in human cells. It induced IL17-directed JAK-STAT signaling and VEGF gene expression, leading to increased cell proliferation as an unwanted effect. To counter this, GO was conjugated with the antioxidant, ginsenoside Rg3, prior to loading with DOX. The conjugation of Rg3 to GO significantly reduced the toxicity of the GO carrier by abolishing ROS production. Furthermore, treatment of cells with GO–Rg3 did not induce IL17-directed JAK-STAT signaling and VEGF gene expression—nor cell proliferation—suggesting GO–Rg3 as a promising drug carrier. The anticancer activity of GO–Rg3–DOX conjugates was investigated against Huh7 hepatocarcinoma and MDA-MB-231 breast cancer cells. GO–Rg3–DOX conjugates significantly reduced cancer cell viability, primarily via downregulation of transcription regulatory genes and upregulation of apoptosis genes. GO–Rg3 is an effective, biocompatible, and pH responsive DOX carrier with potential to improve chemotherapy—at least against liver and breast cancers.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- ginsenoside Rg3
- drug delivery
- doxorubicin
- drug carrier
- graphene oxide
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Rahimi, Shadi, 1 ...
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van Leeuwen, Dan ...
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Roshanzamir, Far ...
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Pandit, Santosh, ...
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Shi, Lei, 1981
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Sasanian, Nima, ...
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visa fler...
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Nielsen, Jens B, ...
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Esbjörner Winter ...
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Mijakovic, Ivan, ...
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visa färre...
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- NATURVETENSKAP
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Pharmaceutics
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Chalmers tekniska högskola