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Psychosocial health modifies associations between HPA-axis function and brain structure in older age
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- van der Velpen, Isabelle F. (författare)
- Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- de Feijter, Maud (författare)
- Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- Raina, Rutika (författare)
- Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd, Atlanta, GA 30322 USA.;OPEN Hlth, 4350 East West Highway,Suite 1100, Bethesda, MD 20814 USA.
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- Özel, Fatih (författare)
- Uppsala universitet,Institutionen för organismbiologi,Miljötoxikologi
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- Perry, Marieke (författare)
- Radboud Univ Nijmegen Med Ctr, Radboudumc Alzheimer Ctr, Dept Geriatr Med, POB 9101, NL-6500 HB Nijmegen, Netherlands.;Radboud Univ Nijmegen Med Ctr, Dept Primary & Community Care, POB 9101, NL-6500 HB Nijmegen, Netherlands.
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- Ikram, M. Arfan (författare)
- Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- Vernooij, Meike W. (författare)
- Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- Luik, Annemarie I. (författare)
- Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Child & Adolescent Psychiat Psychol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands;Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, POB 2040, NL-3000 CA Rotterdam, Netherlands. Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 153
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Dysregulation of the negative feedback loop of the hypothalamic-pituitary-adrenal (HPA) axis may have damaging effects on the brain, potentially under influence of psychosocial health factors. We studied associations between functioning of the negative feedback loop of HPA-axis, measured with a very low-dose dexamethasone suppression test (DST), and brain structure in middle-aged and older adults, and whether these associations were modified by psychosocial health.Methods: From 2006 to 2008, 1259 participants (mean age 57.6 +/- 6.4, 59.6 % female) of the population-based Rotterdam Study completed a very low-dose DST (0.25 mg) and underwent magnetic resonance imaging (MRI) of the brain. Self-reported psychosocial health (depressive symptoms, loneliness, marital status, perceived social support) were assessed in the same time period. Multivariable linear and logistic regression were used to study cross-sectional associations between cortisol response and brain volumetrics, cerebral small vessel disease markers and white matter structural integrity. To assess the effect of psychosocial health on these associations, analyses were further stratified for psychosocial health markers.Results: Cortisol response was not associated with markers of global brain structure in the overall study sample. However, in participants with clinically relevant depressive symptoms, a diminished cortisol response was associated with smaller white matter volume (mean difference: - 1.00 mL, 95 %CI = - 1.89;- 0.10) and smaller white matter hyperintensity volume (mean difference: - 0.03 mL (log), 95 %CI = - 0.05;0.00). In participants with low/moderate perceived social support compared to those with high social support, a diminished cortisol response was associated with larger gray matter volume (mean difference: 0.70 mL, 95 %CI = 0.01;1.39) and higher fractional anisotropy (standardized mean difference 0.03, 95 %CI = 0.00;0.06).Conclusion: Diminished function of the HPA-axis is differently associated with brain structure in communitydwelling middle-aged and older adults with clinically relevant depressive symptoms or suboptimal social support, but not in adults without depressive symptoms or with optimal social support.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- HPA-axis
- Dexamethasone suppression test
- Magnetic resonance imaging
- Brain structure
- Social support
- Depression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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