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- Maasri, Alain, et al.
(författare)
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A global agenda for advancing freshwater biodiversity research
- 2022
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 25:2, s. 255-263
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Tidskriftsartikel (refereegranskat)abstract
- Global freshwater biodiversity is declining dramatically, and meeting the challenges of this crisis requires bold goals and the mobilisation of substantial resources. While the reasons are varied, investments in both research and conservation of freshwater biodiversity lag far behind those in the terrestrial and marine realms. Inspired by a global consultation, we identify 15 pressing priority needs, grouped into five research areas, in an effort to support informed stewardship of freshwater biodiversity. The proposed agenda aims to advance freshwater biodiversity research globally as a critical step in improving coordinated actions towards its sustainable management and conservation.
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| 3. |
- Ramirez-Olivencia, Naim, et al.
(författare)
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Sub-arcsecond LOFAR imaging of Arp 299 at 150 MHz: Tracing the nuclear and diffuse extended emission of a bright LIRG
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 658
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Tidskriftsartikel (refereegranskat)abstract
- Context. Arp 299 is the brightest luminous infrared galaxy (LIRG) within 50 Mpc, with IR luminosity log(LIR/L⊙) = 11.9. It provides a unique laboratory for testing physical processes in merging galaxies. Aims. We study for the first time the low-frequency (∼150 MHz) radio brightness distribution of Arp 299 at subarcsecond resolution, tracing in both compact and extended emission regions the local spectral energy distribution (SED) in order to characterize the dominant emission and absorption processes. Methods. We analysed the spatially resolved emission of Arp 299 revealed by 150 MHz international baseline Low-Frequency Array (LOFAR) and 1.4, 5.0, and 8.4 GHz Very Large Array (VLA) observations. Results. We present the first subarcsecond (0.4″ ×100 pc) image of the whole Arp 299 system at 150 MHz. The high surface brightness sensitivity of our LOFAR observations (∼100 μJy beam-1) allowed us to detect all of the nuclear components detected at higher frequencies, as well as the extended steep-spectrum emission surrounding the nuclei. We obtained spatially resolved, two-point spectral index maps for the whole galaxy: the compact nuclei show relatively flat spectra, while the extended, diffuse component shows a steep spectrum. We fitted the radio SED of the nuclear regions using two different models: a continuous free-free medium model and a clumpy model. The continuous model can explain the SED of the nuclei assuming a population of relativistic electrons subjected to synchrotron, bremsstrahlung, and ionization losses. The clumpy model fits assuming relativistic electrons with negligible energy losses, and thermal fractions that are more typical of star-forming galaxies than those required for the continuous model. Conclusions. Our results confirm the usefulness of combining spatially resolved radio imaging at both MHz and GHz frequencies to characterize in detail the radio emission properties of LIRGs from the central 100 pc out to the kiloparsec galaxy-wide scales.
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| 4. |
- Young, William J., et al.
(författare)
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
- 2022
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
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