| 1. |
- Krop, I., et al.
(författare)
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A putative role for psoriasin in breast tumor progression
- 2005
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Ingår i: Cancer Research. ; 65:24, s. 11326-34
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Tidskriftsartikel (refereegranskat)abstract
- Psoriasin (S100A7) was identifi;ed as a gene highly expressed in psoriatic keratinocytes and highly and more frequently expressed in ductal carcinoma in situ (DCIS) than in invasive breast carcinomas (IBC), suggesting a potential role in tumor progression. Psoriasin expression is associated with poor prognostic factors in both DCIS and IBC. Several putative functions have been proposed for psoriasin in various disease types, but none of these can fully explain its involvement in breast tumor progression. Here, we show that down-regulation of endogenous psoriasin expression via stable short hairpin RNAs in a human IBC cell line (MDA-MB-468) increases cell migration and invasion without influencing cell proliferation and survival in vitro but inhibits tumor growth in vivo. These seemingly paradoxical results are potentially explained by the dramatic up-regulation and down-regulation of matrix metalloproteinase-13 and vascular endothelial growth factor (VEGF), respectively, observed in cells with decreased psoriasin levels compared with controls. Correlating with this, high psoriasin expression in human IBC is associated with increased angiogenesis and worse clinical outcome, and psoriasin mRNA levels are coordinately regulated with VEGF and other genes related to hypoxia and mitochondrial reactive oxygen species (ROS). Based on these results, we propose that psoriasin may play a role in breast tumor progression by promoting angiogenesis and enhancing the selection for cells that overcome its anti-invasive function. This hypothesis may explain why psoriasin expression is highest in high-grade and/or estrogen receptor-negative tumors, as these are associated with increased hypoxia and ROS, a setting in which the angiogenic effects of psoriasin are most important.
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| 2. |
- Nath, B. N., et al.
(författare)
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Pb-210, Th-230, and Be-10 in Central Indian Basin seamount sediments : Signatures of degassing and hydrothermal alteration of recent origin
- 2008
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 35:9, s. L09603-
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Tidskriftsartikel (refereegranskat)abstract
- Isotopic (Pb-210, U-238-Th-230, Be-10), major and trace elements, and micromorphological and microchemical data, were used to identify recent (similar to 100 yrs) hydrothermal alteration of a >200 kyr sedimentary record from the flank of a seamount in the Central Indian Basin located at the edge of the 75 degrees 30'E fracture zone. Alteration effects are also reflected in 1) the depleted sedimentary organic carbon, 2) dissolution features of radiolarian skeletons, 3) the presence of altered minerals such as smectite and zeolites, and 4) distinctly different magnetic properties in the altered sediments. We interpret a predominant influence of neutral chloride type hydrothermal fluids. This is the first report of recently occurring sediment alteration by shallow circulating sub-surface fluids along the Indian Ocean intra-plate seamount environment.
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| 3. |
- Ma, G. B., et al.
(författare)
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Cd(Il)-ethylenediamine mono- and bimetallic complexes - Synthesis and characterization by Cd-113 NMR spectroscopy and single crystal X-ray diffraction
- 2005
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Ingår i: Inorganica Chimica Acta. - : Elsevier BV. - 0020-1693 .- 1873-3255. ; 358:11, s. 3165-3173
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Tidskriftsartikel (refereegranskat)abstract
- Formation of three Cd(II)-ethylenediamine (en) complexes ([Cd(en)(n)](2+), n = 1-3) in aqueous solution and in DMSO solvent has been established by means of Cd-113 NMR spectroscopy. It is clearly shown that Cd(II)-en complexes form primarily in basic solutions. A correlation between the Cd-113 NMR chemical shifts and the ethylenediamine (en) coordination number has been observed and discussed. Two single crystals with the composition [Cd-2(en)(5)](ClO4)(4) (1) and [Cd(en)(3)](ClO4)(2) (2) were prepared from aqueous solution, and their structures were determined by single crystal X-ray diffraction. Cd(II) ions are coordinated by six atoms in both compounds, I and 2: via five N-donor atoms and one O-donor atom forming a bimetallic complex 1, and via six N-donor atoms forming a distorted octahedral monometallic complex 2. Raman spectra of complexes 1 and 2 also provide additional evidence that the cis-form of the bridging en is present in complex 1.
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