SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Rane A) srt2:(2000-2004)"

Sökning: WFRF:(Rane A) > (2000-2004)

  • Resultat 1-10 av 41
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Cnattingius, S, et al. (författare)
  • Caffeine intake and the risk of spontaneous abortion
  • 2003
  • Ingår i: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. - 0278-6915. ; 41:8, s. 1202-1202
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
  •  
7.
  •  
8.
  • Gil Berglund, E, et al. (författare)
  • Growth hormone replacement therapy induces codeine clearance.
  • 2002
  • Ingår i: European journal of clinical investigation. - : Wiley. - 0014-2972. ; 32:7, s. 507-12
  • Tidskriftsartikel (refereegranskat)abstract
    • The increasing clinical use of growth hormone (GH) has raised questions about other than growth-related metabolic effects of this treatment. GH regulates the expression of several hepatic drug metabolising enzymes in the rat, but it is not known whether GH treatment alters the expression of such liver enzymes in man. We have investigated the effects of GH on codeine clearance and two enzymes of the cytochrome P450 (CYP) family, CYP3A and CYP2D6, and UDP-glucuronosyl transferase (UDPGT). These enzymes have a superior importance in hepatic biotransformation of numerous drugs. In addition, CYP3A and UDPGT are catalysts of many reactions with endobiotics such as steroid hormones.We used codeine as a probe drug for assessment of the enzyme activities. Codeine was administered as a single-dose prior to, and after 3 months of GH substitution in GH-deficient patients. Total clearance, and clearance along each of the three primary metabolic pathways of codeine, was assessed.Three months of GH substitution increased the total clearance of codeine (21%, P < 0.01) and clearance catalysed by UDPGT significantly (31%, P < 0.05). The treatment tended to increase the clearance via the CYP3A pathway (83%, P = 0.05).The effects of GH replacement therapy on drug metabolism may have clinical implications when combined with drugs that are substrates of UDPGT and CYP3A. Effects on steroid hormone metabolism with endocrine consequences can not be ruled out.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 41

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy